Impact of functional synapse clusters on neuronal response selectivity
The formation of functional synaptic clusters (FSCs) and their impact on somatic membrane potential (sVm) in vivo are poorly understood. Here, the authors develop a computational approach to show that FSCs have to form via local rather than global plasticity and be moderately large to impact sVm.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15147-6 |
| _version_ | 1818433657064390656 |
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| author | Balázs B. Ujfalussy Judit K. Makara |
| author_facet | Balázs B. Ujfalussy Judit K. Makara |
| author_sort | Balázs B. Ujfalussy |
| collection | DOAJ |
| description | The formation of functional synaptic clusters (FSCs) and their impact on somatic membrane potential (sVm) in vivo are poorly understood. Here, the authors develop a computational approach to show that FSCs have to form via local rather than global plasticity and be moderately large to impact sVm. |
| first_indexed | 2024-12-14T16:24:34Z |
| format | Article |
| id | doaj.art-26deb0c6b32c4646ba6e041777e4dbff |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T16:24:34Z |
| publishDate | 2020-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-26deb0c6b32c4646ba6e041777e4dbff2022-12-21T22:54:44ZengNature PortfolioNature Communications2041-17232020-03-0111111410.1038/s41467-020-15147-6Impact of functional synapse clusters on neuronal response selectivityBalázs B. Ujfalussy0Judit K. Makara1Laboratory of Neuronal Signaling, Institute of Experimental MedicineLaboratory of Neuronal Signaling, Institute of Experimental MedicineThe formation of functional synaptic clusters (FSCs) and their impact on somatic membrane potential (sVm) in vivo are poorly understood. Here, the authors develop a computational approach to show that FSCs have to form via local rather than global plasticity and be moderately large to impact sVm.https://doi.org/10.1038/s41467-020-15147-6 |
| spellingShingle | Balázs B. Ujfalussy Judit K. Makara Impact of functional synapse clusters on neuronal response selectivity Nature Communications |
| title | Impact of functional synapse clusters on neuronal response selectivity |
| title_full | Impact of functional synapse clusters on neuronal response selectivity |
| title_fullStr | Impact of functional synapse clusters on neuronal response selectivity |
| title_full_unstemmed | Impact of functional synapse clusters on neuronal response selectivity |
| title_short | Impact of functional synapse clusters on neuronal response selectivity |
| title_sort | impact of functional synapse clusters on neuronal response selectivity |
| url | https://doi.org/10.1038/s41467-020-15147-6 |
| work_keys_str_mv | AT balazsbujfalussy impactoffunctionalsynapseclustersonneuronalresponseselectivity AT juditkmakara impactoffunctionalsynapseclustersonneuronalresponseselectivity |