The Relationship between Opium Addiction and the Severity of Atherosclerosis, Lipid Profile, Inflammatory Cytokines, and Renal Function in Non-diabetic Patients Subjected to Angiography
Background: Despite traditional beliefs about the beneficial effects of opium use, current evidence suggests an adverse effect of this substance on cardiovascular disease (CVD) risk factors. The present study aimed to investigate the association between opium-addiction status and lipid profile, the...
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| Format: | Article |
| Language: | English |
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Kerman University of Medical Sciences
2022-07-01
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| Series: | Journal of Kerman University of Medical Sciences |
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| Online Access: | https://jkmu.kmu.ac.ir/article_92010_d8adb8b353cc7ec72ad6767f45e54643.pdf |
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| author | Parinaz Onikzeh Aida Kazemi Fatemeh Rahmani Mohamad Masoomi Mina Moridi |
| author_facet | Parinaz Onikzeh Aida Kazemi Fatemeh Rahmani Mohamad Masoomi Mina Moridi |
| author_sort | Parinaz Onikzeh |
| collection | DOAJ |
| description | Background: Despite traditional beliefs about the beneficial effects of opium use, current evidence suggests an adverse effect of this substance on cardiovascular disease (CVD) risk factors. The present study aimed to investigate the association between opium-addiction status and lipid profile, the severity of atherosclerosis (measured by Gensini score), inflammatory cytokines, and renal function among non-diabetic patients subjected to angiography.Methods: This cross-sectional study was conducted on 95 post-angiography patients. Routine tests including lipid profile, blood urea, creatinine, and hematocrit were collected at the time of admission. Also, serum levels of IL-6 and IL-8 were measured using ELISA. Independent sample t-test, Mann-Whitney U test, and chi-square were used to compare variables according to opium addiction. Multivariate regression was conducted to adjust the effect of potential confounding variables.Results: Opium-addict subjects had a higher IL-6 (P=0.049) level and PLT number (P=0.005). In contrast, there was a lower level of TG (P=0.015) and GFR (P=0.039) in the opium-addict group. There was no association between opium addiction and other variables (P>0.05).Conclusion: Although no significant association was observed between addiction and atherosclerosis and even there was a lower level of TG in addict subjects, there was a direct association between the serum IL-6 levels (an important inflammatory cytokine with adverse effects on coronary artery disease) and opium addiction. It has been revealed that confounding variables affect the relationship between opium use and CVD outcomes. Therefore, well-designed prospective studies controlling a vast range of general variables seem to be necessary. |
| first_indexed | 2024-03-13T02:08:51Z |
| format | Article |
| id | doaj.art-26dff32a0cb84d7fb478da5e85342f77 |
| institution | Directory Open Access Journal |
| issn | 2008-2843 |
| language | English |
| last_indexed | 2024-03-13T02:08:51Z |
| publishDate | 2022-07-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Journal of Kerman University of Medical Sciences |
| spelling | doaj.art-26dff32a0cb84d7fb478da5e85342f772023-07-01T05:05:00ZengKerman University of Medical SciencesJournal of Kerman University of Medical Sciences2008-28432022-07-0129434835710.22062/jkmu.2022.9201092010The Relationship between Opium Addiction and the Severity of Atherosclerosis, Lipid Profile, Inflammatory Cytokines, and Renal Function in Non-diabetic Patients Subjected to AngiographyParinaz Onikzeh0Aida Kazemi1Fatemeh Rahmani2Mohamad Masoomi3Mina Moridi4Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranClinical Research Development Unit, Shafa Hospital, kerman University of Medical Sciences, Kerman, IranDepartment of Cardiology, School of Medicine, Bam University of Medical Sciences, Bam, IranCardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, IranCardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, IranBackground: Despite traditional beliefs about the beneficial effects of opium use, current evidence suggests an adverse effect of this substance on cardiovascular disease (CVD) risk factors. The present study aimed to investigate the association between opium-addiction status and lipid profile, the severity of atherosclerosis (measured by Gensini score), inflammatory cytokines, and renal function among non-diabetic patients subjected to angiography.Methods: This cross-sectional study was conducted on 95 post-angiography patients. Routine tests including lipid profile, blood urea, creatinine, and hematocrit were collected at the time of admission. Also, serum levels of IL-6 and IL-8 were measured using ELISA. Independent sample t-test, Mann-Whitney U test, and chi-square were used to compare variables according to opium addiction. Multivariate regression was conducted to adjust the effect of potential confounding variables.Results: Opium-addict subjects had a higher IL-6 (P=0.049) level and PLT number (P=0.005). In contrast, there was a lower level of TG (P=0.015) and GFR (P=0.039) in the opium-addict group. There was no association between opium addiction and other variables (P>0.05).Conclusion: Although no significant association was observed between addiction and atherosclerosis and even there was a lower level of TG in addict subjects, there was a direct association between the serum IL-6 levels (an important inflammatory cytokine with adverse effects on coronary artery disease) and opium addiction. It has been revealed that confounding variables affect the relationship between opium use and CVD outcomes. Therefore, well-designed prospective studies controlling a vast range of general variables seem to be necessary.https://jkmu.kmu.ac.ir/article_92010_d8adb8b353cc7ec72ad6767f45e54643.pdfopiumatherosclerosiscardiovascular diseasesinflammationlipoproteins |
| spellingShingle | Parinaz Onikzeh Aida Kazemi Fatemeh Rahmani Mohamad Masoomi Mina Moridi The Relationship between Opium Addiction and the Severity of Atherosclerosis, Lipid Profile, Inflammatory Cytokines, and Renal Function in Non-diabetic Patients Subjected to Angiography Journal of Kerman University of Medical Sciences opium atherosclerosis cardiovascular diseases inflammation lipoproteins |
| title | The Relationship between Opium Addiction and the Severity of Atherosclerosis, Lipid Profile, Inflammatory Cytokines, and Renal Function in Non-diabetic Patients Subjected to Angiography |
| title_full | The Relationship between Opium Addiction and the Severity of Atherosclerosis, Lipid Profile, Inflammatory Cytokines, and Renal Function in Non-diabetic Patients Subjected to Angiography |
| title_fullStr | The Relationship between Opium Addiction and the Severity of Atherosclerosis, Lipid Profile, Inflammatory Cytokines, and Renal Function in Non-diabetic Patients Subjected to Angiography |
| title_full_unstemmed | The Relationship between Opium Addiction and the Severity of Atherosclerosis, Lipid Profile, Inflammatory Cytokines, and Renal Function in Non-diabetic Patients Subjected to Angiography |
| title_short | The Relationship between Opium Addiction and the Severity of Atherosclerosis, Lipid Profile, Inflammatory Cytokines, and Renal Function in Non-diabetic Patients Subjected to Angiography |
| title_sort | relationship between opium addiction and the severity of atherosclerosis lipid profile inflammatory cytokines and renal function in non diabetic patients subjected to angiography |
| topic | opium atherosclerosis cardiovascular diseases inflammation lipoproteins |
| url | https://jkmu.kmu.ac.ir/article_92010_d8adb8b353cc7ec72ad6767f45e54643.pdf |
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