Prevalence and incidence of Parkinson’s disease and drug-induced parkinsonism in Korea
Abstract Background Parkinson’s disease (PD) and drug-induced parkinsonism (DIP) are the major diseases of parkinsonism. To better understand parkinsonism, we aimed to assess the prevalence and incidence of PD and DIP in Korea from 2012 to 2015. Methods We used the Health Insurance Review and Assess...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-10-01
|
| Series: | BMC Public Health |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12889-019-7664-6 |
| _version_ | 1811292952101650432 |
|---|---|
| author | Sola Han Siin Kim Hyungtae Kim Hae-Won Shin Kyoung-Sae Na Hae Sun Suh |
| author_facet | Sola Han Siin Kim Hyungtae Kim Hae-Won Shin Kyoung-Sae Na Hae Sun Suh |
| author_sort | Sola Han |
| collection | DOAJ |
| description | Abstract Background Parkinson’s disease (PD) and drug-induced parkinsonism (DIP) are the major diseases of parkinsonism. To better understand parkinsonism, we aimed to assess the prevalence and incidence of PD and DIP in Korea from 2012 to 2015. Methods We used the Health Insurance Review and Assessment Service database, which covers the entire population in Korea. We used claims during 2011–2015 to assess epidemiology of PD and DIP during 2012–2015. Retrospective cross-sectional study design was employed to assess prevalence, whereas retrospective cohort study design was used to determine incidence. Patients with at least one claim with ICD-10 G20 and who received antiparkinsonian drugs for at least 60 days were classified as having PD. We excluded patients with antiparkinsonian drugs that can be used for indications other than PD. Patients with at least one claim with ICD-10 G211 or G251 during the prescription period of drugs that are frequently related with DIP were classified as having DIP. Incident cases had a disease-free period of 1 year before diagnosis. To evaluate the significance of changes in the prevalence or incidence over time, Poisson regression was used to determine p for trend. Results The prevalence of PD increased from 156.9 per 100,000 persons in 2012 to 181.3 per 100,000 persons in 2015 (p for trend< 0.0001). The incidence of PD decreased steadily from 35.4 per 100,000 person-years in 2012 to 33.3 per 100,000 person-years in 2015 (p for trend< 0.0001). The prevalence of DIP increased from 7.3 per 100,000 persons in 2012 to 15.4 per 100,000 persons in 2015 (p for trend< 0.0001) and the incidence of DIP increased from 7.1 per 100,000 person-years in 2012 to 13.9 per 100,000 person-years in 2015 (p for trend< 0.0001). Conclusions Our study suggests that the incidence of PD has gradually decreased whereas, the incidence of DIP increased from 2012 to 2015. Further studies are warranted to examine possible causes of increased DIP incidence in order to develop management strategy for parkinsonism. |
| first_indexed | 2024-04-13T04:54:04Z |
| format | Article |
| id | doaj.art-26e0149ce292450b82cabaf99fd7da09 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-04-13T04:54:04Z |
| publishDate | 2019-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-26e0149ce292450b82cabaf99fd7da092022-12-22T03:01:34ZengBMCBMC Public Health1471-24582019-10-011911910.1186/s12889-019-7664-6Prevalence and incidence of Parkinson’s disease and drug-induced parkinsonism in KoreaSola Han0Siin Kim1Hyungtae Kim2Hae-Won Shin3Kyoung-Sae Na4Hae Sun Suh5College of Pharmacy, Pusan National UniversityCollege of Pharmacy, Pusan National UniversityCollege of Pharmacy, Pusan National UniversityDepartment of Neurology, Chung-Ang University College of MedicineGachon University School of MedicineCollege of Pharmacy, Pusan National UniversityAbstract Background Parkinson’s disease (PD) and drug-induced parkinsonism (DIP) are the major diseases of parkinsonism. To better understand parkinsonism, we aimed to assess the prevalence and incidence of PD and DIP in Korea from 2012 to 2015. Methods We used the Health Insurance Review and Assessment Service database, which covers the entire population in Korea. We used claims during 2011–2015 to assess epidemiology of PD and DIP during 2012–2015. Retrospective cross-sectional study design was employed to assess prevalence, whereas retrospective cohort study design was used to determine incidence. Patients with at least one claim with ICD-10 G20 and who received antiparkinsonian drugs for at least 60 days were classified as having PD. We excluded patients with antiparkinsonian drugs that can be used for indications other than PD. Patients with at least one claim with ICD-10 G211 or G251 during the prescription period of drugs that are frequently related with DIP were classified as having DIP. Incident cases had a disease-free period of 1 year before diagnosis. To evaluate the significance of changes in the prevalence or incidence over time, Poisson regression was used to determine p for trend. Results The prevalence of PD increased from 156.9 per 100,000 persons in 2012 to 181.3 per 100,000 persons in 2015 (p for trend< 0.0001). The incidence of PD decreased steadily from 35.4 per 100,000 person-years in 2012 to 33.3 per 100,000 person-years in 2015 (p for trend< 0.0001). The prevalence of DIP increased from 7.3 per 100,000 persons in 2012 to 15.4 per 100,000 persons in 2015 (p for trend< 0.0001) and the incidence of DIP increased from 7.1 per 100,000 person-years in 2012 to 13.9 per 100,000 person-years in 2015 (p for trend< 0.0001). Conclusions Our study suggests that the incidence of PD has gradually decreased whereas, the incidence of DIP increased from 2012 to 2015. Further studies are warranted to examine possible causes of increased DIP incidence in order to develop management strategy for parkinsonism.http://link.springer.com/article/10.1186/s12889-019-7664-6Drug-induced parkinsonismParkinson’s diseasePrevalenceIncidencePharmacoepidemiology |
| spellingShingle | Sola Han Siin Kim Hyungtae Kim Hae-Won Shin Kyoung-Sae Na Hae Sun Suh Prevalence and incidence of Parkinson’s disease and drug-induced parkinsonism in Korea BMC Public Health Drug-induced parkinsonism Parkinson’s disease Prevalence Incidence Pharmacoepidemiology |
| title | Prevalence and incidence of Parkinson’s disease and drug-induced parkinsonism in Korea |
| title_full | Prevalence and incidence of Parkinson’s disease and drug-induced parkinsonism in Korea |
| title_fullStr | Prevalence and incidence of Parkinson’s disease and drug-induced parkinsonism in Korea |
| title_full_unstemmed | Prevalence and incidence of Parkinson’s disease and drug-induced parkinsonism in Korea |
| title_short | Prevalence and incidence of Parkinson’s disease and drug-induced parkinsonism in Korea |
| title_sort | prevalence and incidence of parkinson s disease and drug induced parkinsonism in korea |
| topic | Drug-induced parkinsonism Parkinson’s disease Prevalence Incidence Pharmacoepidemiology |
| url | http://link.springer.com/article/10.1186/s12889-019-7664-6 |
| work_keys_str_mv | AT solahan prevalenceandincidenceofparkinsonsdiseaseanddruginducedparkinsonisminkorea AT siinkim prevalenceandincidenceofparkinsonsdiseaseanddruginducedparkinsonisminkorea AT hyungtaekim prevalenceandincidenceofparkinsonsdiseaseanddruginducedparkinsonisminkorea AT haewonshin prevalenceandincidenceofparkinsonsdiseaseanddruginducedparkinsonisminkorea AT kyoungsaena prevalenceandincidenceofparkinsonsdiseaseanddruginducedparkinsonisminkorea AT haesunsuh prevalenceandincidenceofparkinsonsdiseaseanddruginducedparkinsonisminkorea |