Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate
A simple and rapid precipitation titration method was developed and validated to determine sulfate ion content in indinavir sulfate raw material. 0.1 mol L-1 lead nitrate volumetric solution was used as titrant employing potentiometric endpoint determination using a lead-specific electrode. The Unit...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2005-02-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000100011 |
| _version_ | 1818853394899533824 |
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| author | Breno de Carvalho e Silva Lígia Maria Moreira de Campos Gerson Antônio Pianetti |
| author_facet | Breno de Carvalho e Silva Lígia Maria Moreira de Campos Gerson Antônio Pianetti |
| author_sort | Breno de Carvalho e Silva |
| collection | DOAJ |
| description | A simple and rapid precipitation titration method was developed and validated to determine sulfate ion content in indinavir sulfate raw material. 0.1 mol L-1 lead nitrate volumetric solution was used as titrant employing potentiometric endpoint determination using a lead-specific electrode. The United States Pharmacopoeia Forum indicates a potentiometric method for sulfate ion quantitation using 0.1 mol L-1 lead perchlorate as titrant. Both methods were validated concerning linearity, precision and accuracy, yielding good results. The sulfate ion content found by the two validated methods was compared by the statistical t-student test, indicating that there was no statistically significant difference between the methods. |
| first_indexed | 2024-12-19T07:36:08Z |
| format | Article |
| id | doaj.art-26e04e8561b64db5bcc4de347a36cfa8 |
| institution | Directory Open Access Journal |
| issn | 0100-4042 1678-7064 |
| language | English |
| last_indexed | 2024-12-19T07:36:08Z |
| publishDate | 2005-02-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-26e04e8561b64db5bcc4de347a36cfa82022-12-21T20:30:35ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642005-02-01281545610.1590/S0100-40422005000100011Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfateBreno de Carvalho e SilvaLígia Maria Moreira de CamposGerson Antônio PianettiA simple and rapid precipitation titration method was developed and validated to determine sulfate ion content in indinavir sulfate raw material. 0.1 mol L-1 lead nitrate volumetric solution was used as titrant employing potentiometric endpoint determination using a lead-specific electrode. The United States Pharmacopoeia Forum indicates a potentiometric method for sulfate ion quantitation using 0.1 mol L-1 lead perchlorate as titrant. Both methods were validated concerning linearity, precision and accuracy, yielding good results. The sulfate ion content found by the two validated methods was compared by the statistical t-student test, indicating that there was no statistically significant difference between the methods.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000100011indinavir sulfatetitrationsulfate ion content |
| spellingShingle | Breno de Carvalho e Silva Lígia Maria Moreira de Campos Gerson Antônio Pianetti Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate Química Nova indinavir sulfate titration sulfate ion content |
| title | Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate |
| title_full | Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate |
| title_fullStr | Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate |
| title_full_unstemmed | Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate |
| title_short | Development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate |
| title_sort | development and validation of an alternative titration method for the determination of sulfate ion in indinavir sulfate |
| topic | indinavir sulfate titration sulfate ion content |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000100011 |
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