Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis
Objectives: To assess the diagnostic accuracy of Procalcitonin in maternal serum and umbilical cord blood samples to predict Early onset neonatal sepsis (EONS). Study Design: It was a Prospective analytical cohort study. Pregnant women ≥ 34 weeks gestation in active labour, with risk factors for EON...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
|
| Series: | European Journal of Obstetrics & Gynecology and Reproductive Biology: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590161323000467 |
| _version_ | 1797682991182381056 |
|---|---|
| author | Puja Yadav Kavita Agarwal Anita Rani Rupali Dewan Harish Chellani |
| author_facet | Puja Yadav Kavita Agarwal Anita Rani Rupali Dewan Harish Chellani |
| author_sort | Puja Yadav |
| collection | DOAJ |
| description | Objectives: To assess the diagnostic accuracy of Procalcitonin in maternal serum and umbilical cord blood samples to predict Early onset neonatal sepsis (EONS). Study Design: It was a Prospective analytical cohort study. Pregnant women ≥ 34 weeks gestation in active labour, with risk factors for EONS were included in the study. Maternal blood samples at recruitment and umbilical cord blood samples after delivery were taken for Total leucocyte count (TLC), high sensitivity C-Reactive Protein (hs-CRP) and Procalcitonin. Newborns were classified into non-infected, suspected and proven infection. Sensitivity, specificity and diagnostic accuracy of maternal and cord blood procalcitonin, TLC and hs-CRP were calculated. Results: A total of 200 women were recruited. Maternal procalcitonin had a superior diagnostic accuracy of 99% compared to maternal TLC and maternal hs-CRP. Also, cord blood procalcitonin had a diagnostic accuracy of 95%. Conclusion: Procalcitonin in both maternal as well as cord blood is a promising biomarker to detect EONS with high diagnostic accuracy. |
| first_indexed | 2024-03-12T00:07:55Z |
| format | Article |
| id | doaj.art-26e085ba9b3a4442adadf209ebe494ce |
| institution | Directory Open Access Journal |
| issn | 2590-1613 |
| language | English |
| last_indexed | 2024-03-12T00:07:55Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Obstetrics & Gynecology and Reproductive Biology: X |
| spelling | doaj.art-26e085ba9b3a4442adadf209ebe494ce2023-09-16T05:31:42ZengElsevierEuropean Journal of Obstetrics & Gynecology and Reproductive Biology: X2590-16132023-09-0119100221Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsisPuja Yadav0Kavita Agarwal1Anita Rani2Rupali Dewan3Harish Chellani4Deptt. Of Obs. & Gynae, VMMC & Safdarjung Hospital, Delhi, IndiaDeptt. Of Obs. & Gynae, VMMC & Safdarjung Hospital, Delhi, India; Correspondence to: Department Obs. And Gynae, VMMC & Safdarjung Hospital, New Delhi 110029, India.Deptt. of Biochemistry, VMMC & Safdarjung Hospital, Delhi, IndiaDeptt. Of Obs. & Gynae, VMMC & Safdarjung Hospital, Delhi, IndiaDeptt. Of Paediatrics, VMMC & Safdarjung Hospital, Delhi, IndiaObjectives: To assess the diagnostic accuracy of Procalcitonin in maternal serum and umbilical cord blood samples to predict Early onset neonatal sepsis (EONS). Study Design: It was a Prospective analytical cohort study. Pregnant women ≥ 34 weeks gestation in active labour, with risk factors for EONS were included in the study. Maternal blood samples at recruitment and umbilical cord blood samples after delivery were taken for Total leucocyte count (TLC), high sensitivity C-Reactive Protein (hs-CRP) and Procalcitonin. Newborns were classified into non-infected, suspected and proven infection. Sensitivity, specificity and diagnostic accuracy of maternal and cord blood procalcitonin, TLC and hs-CRP were calculated. Results: A total of 200 women were recruited. Maternal procalcitonin had a superior diagnostic accuracy of 99% compared to maternal TLC and maternal hs-CRP. Also, cord blood procalcitonin had a diagnostic accuracy of 95%. Conclusion: Procalcitonin in both maternal as well as cord blood is a promising biomarker to detect EONS with high diagnostic accuracy.http://www.sciencedirect.com/science/article/pii/S2590161323000467ProcalcitoninNeonatal sepsisC-Reactive Protein |
| spellingShingle | Puja Yadav Kavita Agarwal Anita Rani Rupali Dewan Harish Chellani Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis European Journal of Obstetrics & Gynecology and Reproductive Biology: X Procalcitonin Neonatal sepsis C-Reactive Protein |
| title | Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis |
| title_full | Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis |
| title_fullStr | Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis |
| title_full_unstemmed | Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis |
| title_short | Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis |
| title_sort | procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis |
| topic | Procalcitonin Neonatal sepsis C-Reactive Protein |
| url | http://www.sciencedirect.com/science/article/pii/S2590161323000467 |
| work_keys_str_mv | AT pujayadav procalcitoninlevelsinmaternalserumandcordbloodasmarkerfordiagnosisofearlyonsetneonatalsepsis AT kavitaagarwal procalcitoninlevelsinmaternalserumandcordbloodasmarkerfordiagnosisofearlyonsetneonatalsepsis AT anitarani procalcitoninlevelsinmaternalserumandcordbloodasmarkerfordiagnosisofearlyonsetneonatalsepsis AT rupalidewan procalcitoninlevelsinmaternalserumandcordbloodasmarkerfordiagnosisofearlyonsetneonatalsepsis AT harishchellani procalcitoninlevelsinmaternalserumandcordbloodasmarkerfordiagnosisofearlyonsetneonatalsepsis |