Evaluation of the Hydrophilic, Cohesive, and Physical Properties of Eight Hyaluronic Acid Fillers: Clinical Implications of Gel Differentiation
Kaitlyn M Enright,1 Steven F Weiner,2 Kalpna K Durairaj,3 Mirko S Gilardino,4 Andreas Nikolis5 1Clinical Research Unit, Erevna Innovations Inc, Westmount, Quebec, Canada; 2The Aesthetic Clinique, New York, NY, USA; 3Beauty by Dr. Kay, Pasadena, CA, USA; 4Division of Plastic Surgery, McGill Universit...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-01-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/evaluation-of-the-hydrophilic-cohesive-and-physical-properties-of-eigh-peer-reviewed-fulltext-article-CCID |
| _version_ | 1797355338857447424 |
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| author | Enright KM Weiner SF Durairaj KK Gilardino MS Nikolis A |
| author_facet | Enright KM Weiner SF Durairaj KK Gilardino MS Nikolis A |
| author_sort | Enright KM |
| collection | DOAJ |
| description | Kaitlyn M Enright,1 Steven F Weiner,2 Kalpna K Durairaj,3 Mirko S Gilardino,4 Andreas Nikolis5 1Clinical Research Unit, Erevna Innovations Inc, Westmount, Quebec, Canada; 2The Aesthetic Clinique, New York, NY, USA; 3Beauty by Dr. Kay, Pasadena, CA, USA; 4Division of Plastic Surgery, McGill University, Montreal, Quebec, Canada; 5Clinical Research Unit, Erevna Innovations Inc, Westmount, Quebec, Canada; Department of Plastic Surgery, McGill University, Montreal, Quebec, CanadaCorrespondence: Kaitlyn M Enright, Clinical Research Unit, Erevna Innovations Inc, 376 Victoria Ave., Suite 400A, Westmount, QC, H3Z 1C3, Canada, Tel +1 514-488-0163 Ext 256, Email research@vicpark.comBackground: Hyaluronic acid (HA) fillers are used to treat an array of aesthetic indications. Proper filler selection is paramount for successful patient outcomes. However, many important physiochemical and physical properties that impact HA gel behavior remain undefined.Purpose: To evaluate the hydrophilicity, cohesivity and particle size of eight commercial HA fillers manufactured by either Non-Animal Stabilized Hyaluronic Acid (NASHA) or Optimal Balance Technology (OBT) techniques.Methods and Materials: Three individual in vitro experiments were performed to assess HA swelling capacity, cohesion, and particle size. Image analyses, blinded evaluation using the Gavard-Sundaram Cohesivity Scale, and laser diffraction technology were utilized, respectively.Results: Compared to fillers manufactured with NASHA technology, OBT products demonstrated greater swelling capacity, cohesion, and wider particle size distributions. Strong positive correlations between swelling factor, degree of cohesivity, and increasing widths of the particle size distributions were observed.Conclusions: The hydrophilicity, cohesivity and particle size distributions vary among HA fillers manufactured with different techniques. The creation of new labels identifying products based on their unique combination of physiochemical and physical characteristics may help guide appropriate selection of HA fillers to optimize patient outcomes.Keywords: Optimal balance technology, OBT, Non-animal stabilized hyaluronic acid, NASHA, aesthetics |
| first_indexed | 2024-03-08T14:09:41Z |
| format | Article |
| id | doaj.art-26e13299973e41ceaf1f5923a06a24d6 |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-03-08T14:09:41Z |
| publishDate | 2024-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-26e13299973e41ceaf1f5923a06a24d62024-01-14T18:47:16ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152024-01-01Volume 178910189681Evaluation of the Hydrophilic, Cohesive, and Physical Properties of Eight Hyaluronic Acid Fillers: Clinical Implications of Gel DifferentiationEnright KMWeiner SFDurairaj KKGilardino MSNikolis AKaitlyn M Enright,1 Steven F Weiner,2 Kalpna K Durairaj,3 Mirko S Gilardino,4 Andreas Nikolis5 1Clinical Research Unit, Erevna Innovations Inc, Westmount, Quebec, Canada; 2The Aesthetic Clinique, New York, NY, USA; 3Beauty by Dr. Kay, Pasadena, CA, USA; 4Division of Plastic Surgery, McGill University, Montreal, Quebec, Canada; 5Clinical Research Unit, Erevna Innovations Inc, Westmount, Quebec, Canada; Department of Plastic Surgery, McGill University, Montreal, Quebec, CanadaCorrespondence: Kaitlyn M Enright, Clinical Research Unit, Erevna Innovations Inc, 376 Victoria Ave., Suite 400A, Westmount, QC, H3Z 1C3, Canada, Tel +1 514-488-0163 Ext 256, Email research@vicpark.comBackground: Hyaluronic acid (HA) fillers are used to treat an array of aesthetic indications. Proper filler selection is paramount for successful patient outcomes. However, many important physiochemical and physical properties that impact HA gel behavior remain undefined.Purpose: To evaluate the hydrophilicity, cohesivity and particle size of eight commercial HA fillers manufactured by either Non-Animal Stabilized Hyaluronic Acid (NASHA) or Optimal Balance Technology (OBT) techniques.Methods and Materials: Three individual in vitro experiments were performed to assess HA swelling capacity, cohesion, and particle size. Image analyses, blinded evaluation using the Gavard-Sundaram Cohesivity Scale, and laser diffraction technology were utilized, respectively.Results: Compared to fillers manufactured with NASHA technology, OBT products demonstrated greater swelling capacity, cohesion, and wider particle size distributions. Strong positive correlations between swelling factor, degree of cohesivity, and increasing widths of the particle size distributions were observed.Conclusions: The hydrophilicity, cohesivity and particle size distributions vary among HA fillers manufactured with different techniques. The creation of new labels identifying products based on their unique combination of physiochemical and physical characteristics may help guide appropriate selection of HA fillers to optimize patient outcomes.Keywords: Optimal balance technology, OBT, Non-animal stabilized hyaluronic acid, NASHA, aestheticshttps://www.dovepress.com/evaluation-of-the-hydrophilic-cohesive-and-physical-properties-of-eigh-peer-reviewed-fulltext-article-CCIDsoft tissue augmentationinjectablesoptimal balance technology (obt)non-animal stabilized hyaluronic acid (nasha)aesthetics. |
| spellingShingle | Enright KM Weiner SF Durairaj KK Gilardino MS Nikolis A Evaluation of the Hydrophilic, Cohesive, and Physical Properties of Eight Hyaluronic Acid Fillers: Clinical Implications of Gel Differentiation Clinical, Cosmetic and Investigational Dermatology soft tissue augmentation injectables optimal balance technology (obt) non-animal stabilized hyaluronic acid (nasha) aesthetics. |
| title | Evaluation of the Hydrophilic, Cohesive, and Physical Properties of Eight Hyaluronic Acid Fillers: Clinical Implications of Gel Differentiation |
| title_full | Evaluation of the Hydrophilic, Cohesive, and Physical Properties of Eight Hyaluronic Acid Fillers: Clinical Implications of Gel Differentiation |
| title_fullStr | Evaluation of the Hydrophilic, Cohesive, and Physical Properties of Eight Hyaluronic Acid Fillers: Clinical Implications of Gel Differentiation |
| title_full_unstemmed | Evaluation of the Hydrophilic, Cohesive, and Physical Properties of Eight Hyaluronic Acid Fillers: Clinical Implications of Gel Differentiation |
| title_short | Evaluation of the Hydrophilic, Cohesive, and Physical Properties of Eight Hyaluronic Acid Fillers: Clinical Implications of Gel Differentiation |
| title_sort | evaluation of the hydrophilic cohesive and physical properties of eight hyaluronic acid fillers clinical implications of gel differentiation |
| topic | soft tissue augmentation injectables optimal balance technology (obt) non-animal stabilized hyaluronic acid (nasha) aesthetics. |
| url | https://www.dovepress.com/evaluation-of-the-hydrophilic-cohesive-and-physical-properties-of-eigh-peer-reviewed-fulltext-article-CCID |
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