The Anti-Apoptotic Role of Neuroglobin
The small heme-protein neuroglobin is expressed at high concentrations in certain brain neurons and in the rod cells of the retina. This paper reviews the many studies which have recently identified a protective role for neuroglobin, in a wide range of situations involving apoptotic cell death. The...
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-11-01
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| Series: | Cells |
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| Online Access: | http://www.mdpi.com/2073-4409/1/4/1133 |
| _version_ | 1797762101990653952 |
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| author | Thomas Brittain |
| author_facet | Thomas Brittain |
| author_sort | Thomas Brittain |
| collection | DOAJ |
| description | The small heme-protein neuroglobin is expressed at high concentrations in certain brain neurons and in the rod cells of the retina. This paper reviews the many studies which have recently identified a protective role for neuroglobin, in a wide range of situations involving apoptotic cell death. The origins of this protective mechanism are discussed in terms of both experimental results and computational modeling of the intrinsic pathway of apoptosis, which shows that neuroglobin can intervene in this process by a reaction with released mitochondrial cytochrome c. An integrated model, based on the various molecular actions of both neuroglobin and cytochrome c, is developed, which accounts for the cellular distribution of neuroglobin. |
| first_indexed | 2024-03-12T19:22:32Z |
| format | Article |
| id | doaj.art-26e230619170484980078b2f63000837 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T19:22:32Z |
| publishDate | 2012-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-26e230619170484980078b2f630008372023-08-02T05:01:00ZengMDPI AGCells2073-44092012-11-01141133115510.3390/cells1041133The Anti-Apoptotic Role of NeuroglobinThomas BrittainThe small heme-protein neuroglobin is expressed at high concentrations in certain brain neurons and in the rod cells of the retina. This paper reviews the many studies which have recently identified a protective role for neuroglobin, in a wide range of situations involving apoptotic cell death. The origins of this protective mechanism are discussed in terms of both experimental results and computational modeling of the intrinsic pathway of apoptosis, which shows that neuroglobin can intervene in this process by a reaction with released mitochondrial cytochrome c. An integrated model, based on the various molecular actions of both neuroglobin and cytochrome c, is developed, which accounts for the cellular distribution of neuroglobin.http://www.mdpi.com/2073-4409/1/4/1133apoptosisneuroglobinneurons |
| spellingShingle | Thomas Brittain The Anti-Apoptotic Role of Neuroglobin Cells apoptosis neuroglobin neurons |
| title | The Anti-Apoptotic Role of Neuroglobin |
| title_full | The Anti-Apoptotic Role of Neuroglobin |
| title_fullStr | The Anti-Apoptotic Role of Neuroglobin |
| title_full_unstemmed | The Anti-Apoptotic Role of Neuroglobin |
| title_short | The Anti-Apoptotic Role of Neuroglobin |
| title_sort | anti apoptotic role of neuroglobin |
| topic | apoptosis neuroglobin neurons |
| url | http://www.mdpi.com/2073-4409/1/4/1133 |
| work_keys_str_mv | AT thomasbrittain theantiapoptoticroleofneuroglobin AT thomasbrittain antiapoptoticroleofneuroglobin |