Leukocyte adhesion - a fundamental process in leukocyte physiology
Leukocyte adhesion is of pivotal functional importance. The adhesion involves several different adhesion molecules, the most important of which are the leukocyte ß2-integrins (CD11/CD18), the intercellular adhesion molecules, and the selectins. We and others have extensively studied the specificity...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Associação Brasileira de Divulgação Científica
1999-01-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500003 |
| _version_ | 1811216997101338624 |
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| author | Gahmberg C.G. Valmu L. Tian L. Kotovuori P. Fagerholm S. Kotovuori A. Kantor C. Hilden T. |
| author_facet | Gahmberg C.G. Valmu L. Tian L. Kotovuori P. Fagerholm S. Kotovuori A. Kantor C. Hilden T. |
| author_sort | Gahmberg C.G. |
| collection | DOAJ |
| description | Leukocyte adhesion is of pivotal functional importance. The adhesion involves several different adhesion molecules, the most important of which are the leukocyte ß2-integrins (CD11/CD18), the intercellular adhesion molecules, and the selectins. We and others have extensively studied the specificity and binding sites in the integrins and the intercellular adhesion molecules for their receptors and ligands. The integrins have to become activated to exert their functions but the possible mechanisms of activation remain poorly understood. Importantly, a few novel intercellular adhesion molecules have been recently described, which seem to function only in specific tissues. Furthermore, it is becoming increasingly apparent that changes in integrins and intercellular adhesion molecules are associated with a number of acute and chronic diseases. |
| first_indexed | 2024-04-12T06:46:37Z |
| format | Article |
| id | doaj.art-26e41555fd694322b42446e2e4f336f6 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 0034-7310 |
| language | English |
| last_indexed | 2024-04-12T06:46:37Z |
| publishDate | 1999-01-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-26e41555fd694322b42446e2e4f336f62022-12-22T03:43:30ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X0034-73101999-01-01325511517Leukocyte adhesion - a fundamental process in leukocyte physiologyGahmberg C.G.Valmu L.Tian L.Kotovuori P.Fagerholm S.Kotovuori A.Kantor C.Hilden T.Leukocyte adhesion is of pivotal functional importance. The adhesion involves several different adhesion molecules, the most important of which are the leukocyte ß2-integrins (CD11/CD18), the intercellular adhesion molecules, and the selectins. We and others have extensively studied the specificity and binding sites in the integrins and the intercellular adhesion molecules for their receptors and ligands. The integrins have to become activated to exert their functions but the possible mechanisms of activation remain poorly understood. Importantly, a few novel intercellular adhesion molecules have been recently described, which seem to function only in specific tissues. Furthermore, it is becoming increasingly apparent that changes in integrins and intercellular adhesion molecules are associated with a number of acute and chronic diseases.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500003leukocyteadhesionintegrinICAMmembraneglycoprotein |
| spellingShingle | Gahmberg C.G. Valmu L. Tian L. Kotovuori P. Fagerholm S. Kotovuori A. Kantor C. Hilden T. Leukocyte adhesion - a fundamental process in leukocyte physiology Brazilian Journal of Medical and Biological Research leukocyte adhesion integrin ICAM membrane glycoprotein |
| title | Leukocyte adhesion - a fundamental process in leukocyte physiology |
| title_full | Leukocyte adhesion - a fundamental process in leukocyte physiology |
| title_fullStr | Leukocyte adhesion - a fundamental process in leukocyte physiology |
| title_full_unstemmed | Leukocyte adhesion - a fundamental process in leukocyte physiology |
| title_short | Leukocyte adhesion - a fundamental process in leukocyte physiology |
| title_sort | leukocyte adhesion a fundamental process in leukocyte physiology |
| topic | leukocyte adhesion integrin ICAM membrane glycoprotein |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500003 |
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