Fluorine-18 Labelled Radioligands for PET Imaging of Cyclooxygenase-2
Molecular imaging probes enable the early and accurate detection of disease-specific biomarkers and facilitate personalized treatment of many chronic diseases, including cancer. Among current clinically used functional imaging modalities, positron emission tomography (PET) plays a significant role i...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/12/3722 |
| _version_ | 1797484048779575296 |
|---|---|
| author | Jatinder Kaur Atul Bhardwaj Frank Wuest |
| author_facet | Jatinder Kaur Atul Bhardwaj Frank Wuest |
| author_sort | Jatinder Kaur |
| collection | DOAJ |
| description | Molecular imaging probes enable the early and accurate detection of disease-specific biomarkers and facilitate personalized treatment of many chronic diseases, including cancer. Among current clinically used functional imaging modalities, positron emission tomography (PET) plays a significant role in cancer detection and in monitoring the response to therapeutic interventions. Several preclinical and clinical studies have demonstrated the crucial involvement of cyclooxygenase-2 (COX-2) isozyme in cancer development and progression, making COX-2 a promising cancer biomarker. A variety of COX-2-targeting PET radioligands has been developed based on anti-inflammatory drugs and selective COX-2 inhibitors. However, many of those suffer from non-specific binding and insufficient metabolic stability. This article highlights examples of COX-2-targeting PET radioligands labelled with the short-lived positron emitter <sup>18</sup>F, including radiosynthesis and PET imaging studies published in the last decade (2012–2021). |
| first_indexed | 2024-03-09T22:55:56Z |
| format | Article |
| id | doaj.art-26e5399e1d45488e8d470d34c4a85a2a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T22:55:56Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-26e5399e1d45488e8d470d34c4a85a2a2023-11-23T18:10:11ZengMDPI AGMolecules1420-30492022-06-012712372210.3390/molecules27123722Fluorine-18 Labelled Radioligands for PET Imaging of Cyclooxygenase-2Jatinder Kaur0Atul Bhardwaj1Frank Wuest2Department of Oncology, University of Alberta, Edmonton, AB T6G 1Z2, CanadaDepartment of Oncology, University of Alberta, Edmonton, AB T6G 1Z2, CanadaDepartment of Oncology, University of Alberta, Edmonton, AB T6G 1Z2, CanadaMolecular imaging probes enable the early and accurate detection of disease-specific biomarkers and facilitate personalized treatment of many chronic diseases, including cancer. Among current clinically used functional imaging modalities, positron emission tomography (PET) plays a significant role in cancer detection and in monitoring the response to therapeutic interventions. Several preclinical and clinical studies have demonstrated the crucial involvement of cyclooxygenase-2 (COX-2) isozyme in cancer development and progression, making COX-2 a promising cancer biomarker. A variety of COX-2-targeting PET radioligands has been developed based on anti-inflammatory drugs and selective COX-2 inhibitors. However, many of those suffer from non-specific binding and insufficient metabolic stability. This article highlights examples of COX-2-targeting PET radioligands labelled with the short-lived positron emitter <sup>18</sup>F, including radiosynthesis and PET imaging studies published in the last decade (2012–2021).https://www.mdpi.com/1420-3049/27/12/3722COX-2inhibitorradiotracerfluorine-18radionuclideradiolabelling |
| spellingShingle | Jatinder Kaur Atul Bhardwaj Frank Wuest Fluorine-18 Labelled Radioligands for PET Imaging of Cyclooxygenase-2 Molecules COX-2 inhibitor radiotracer fluorine-18 radionuclide radiolabelling |
| title | Fluorine-18 Labelled Radioligands for PET Imaging of Cyclooxygenase-2 |
| title_full | Fluorine-18 Labelled Radioligands for PET Imaging of Cyclooxygenase-2 |
| title_fullStr | Fluorine-18 Labelled Radioligands for PET Imaging of Cyclooxygenase-2 |
| title_full_unstemmed | Fluorine-18 Labelled Radioligands for PET Imaging of Cyclooxygenase-2 |
| title_short | Fluorine-18 Labelled Radioligands for PET Imaging of Cyclooxygenase-2 |
| title_sort | fluorine 18 labelled radioligands for pet imaging of cyclooxygenase 2 |
| topic | COX-2 inhibitor radiotracer fluorine-18 radionuclide radiolabelling |
| url | https://www.mdpi.com/1420-3049/27/12/3722 |
| work_keys_str_mv | AT jatinderkaur fluorine18labelledradioligandsforpetimagingofcyclooxygenase2 AT atulbhardwaj fluorine18labelledradioligandsforpetimagingofcyclooxygenase2 AT frankwuest fluorine18labelledradioligandsforpetimagingofcyclooxygenase2 |