Long-Term Outcomes of Congenital Diaphragmatic Hernia: Report of a Multicenter Study in Japan
Background: Treatment modalities for neonates with congenital diaphragmatic hernia (CDH) have greatly improved in recent years, with a concomitant increase in survival. However, long-term outcomes restrict the identification of optimal care pathways for CDH survivors in adolescence and adulthood. Th...
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MDPI AG
2022-06-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/6/856 |
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| author | Masaya Yamoto Kouji Nagata Keita Terui Masahiro Hayakawa Hiroomi Okuyama Shoichiro Amari Akiko Yokoi Kouji Masumoto Tadaharu Okazaki Noboru Inamura Katsuaki Toyoshima Yuhki Koike Yuta Yazaki Taizo Furukawa Noriaki Usui |
| author_facet | Masaya Yamoto Kouji Nagata Keita Terui Masahiro Hayakawa Hiroomi Okuyama Shoichiro Amari Akiko Yokoi Kouji Masumoto Tadaharu Okazaki Noboru Inamura Katsuaki Toyoshima Yuhki Koike Yuta Yazaki Taizo Furukawa Noriaki Usui |
| author_sort | Masaya Yamoto |
| collection | DOAJ |
| description | Background: Treatment modalities for neonates with congenital diaphragmatic hernia (CDH) have greatly improved in recent years, with a concomitant increase in survival. However, long-term outcomes restrict the identification of optimal care pathways for CDH survivors in adolescence and adulthood. Therefore, we evaluated the long-term outcomes within the Japanese CDH Study Group (JCDHSG). Methods: Participants were born with CDH between 2006 and 2018 according to the JCDHSG. Participants were enrolled in the database at 1.5, 3, 6, and 12 years old. Follow-up items included long-term complications, operations for long-term complication, and home medical care. Results: A total of 747 patients were included in this study, with 626 survivors (83.8%) and 121 non-survivors (16.2%). At 1.5, 3, 6, and 12 years old, 45.4%, 36.5%, 34.8%, and 43.6% developed complications, and 20.1%, 14.7%, 11.5%, and 5.1% of participants required home care, respectively. Recurrence, pneumonia, pneumothorax, gastroesophageal reflux disease, and intestinal obstruction decreased with age, and thoracic deformity increased with age. Conclusions: As CDH survival rates improve, there is a need for continued research and fine-tuning of long-term care to optimize appropriate surveillance and long-term follow-up. |
| first_indexed | 2024-03-10T00:06:58Z |
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| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T00:06:58Z |
| publishDate | 2022-06-01 |
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| record_format | Article |
| series | Children |
| spelling | doaj.art-26e5df0b98bb43f3a409de5f5e7af3812023-11-23T16:05:59ZengMDPI AGChildren2227-90672022-06-019685610.3390/children9060856Long-Term Outcomes of Congenital Diaphragmatic Hernia: Report of a Multicenter Study in JapanMasaya Yamoto0Kouji Nagata1Keita Terui2Masahiro Hayakawa3Hiroomi Okuyama4Shoichiro Amari5Akiko Yokoi6Kouji Masumoto7Tadaharu Okazaki8Noboru Inamura9Katsuaki Toyoshima10Yuhki Koike11Yuta Yazaki12Taizo Furukawa13Noriaki Usui14Department of Pediatric Surgery, Shizuoka Children’s Hospital, Shizuoka 420-8660, JapanDepartment of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-Ku, Fukuoka 812-8582, JapanDepartment of Pediatric Surgery, Chiba University Graduate School of Medicine, Chiba 260-867, JapanDivision of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya 466-8560, JapanDepartment of Pediatric Surgery, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanDivision of Neonatology, National Center for Child Health and Development, Tokyo 157-0074, JapanDepartment of Pediatric Surgery, Kobe Children’s Hospital, Kobe 650-0047, JapanDepartment of Pediatric Surgery, Tsukuba University, Tsukuba 305-8577, JapanDepartment of Pediatric Surgery, Juntendo University Urayasu Hospital, Urayasu 279-0021, JapanDepartment of Pediatrics, Kindai University Faculty of Medicine, Osaka-Sayama 589-0014, JapanDepartment of Neonatology, Kanagawa Children’s Medical Center, Yokohama 232-8555, JapanDepartment of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu 514-8507, JapanDepartment of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, Tokyo 113-8421, JapanDepartment of Pediatric Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Pediatric Surgery, Osaka Women’s and Children’s Hospital, Izumi 594-1101, JapanBackground: Treatment modalities for neonates with congenital diaphragmatic hernia (CDH) have greatly improved in recent years, with a concomitant increase in survival. However, long-term outcomes restrict the identification of optimal care pathways for CDH survivors in adolescence and adulthood. Therefore, we evaluated the long-term outcomes within the Japanese CDH Study Group (JCDHSG). Methods: Participants were born with CDH between 2006 and 2018 according to the JCDHSG. Participants were enrolled in the database at 1.5, 3, 6, and 12 years old. Follow-up items included long-term complications, operations for long-term complication, and home medical care. Results: A total of 747 patients were included in this study, with 626 survivors (83.8%) and 121 non-survivors (16.2%). At 1.5, 3, 6, and 12 years old, 45.4%, 36.5%, 34.8%, and 43.6% developed complications, and 20.1%, 14.7%, 11.5%, and 5.1% of participants required home care, respectively. Recurrence, pneumonia, pneumothorax, gastroesophageal reflux disease, and intestinal obstruction decreased with age, and thoracic deformity increased with age. Conclusions: As CDH survival rates improve, there is a need for continued research and fine-tuning of long-term care to optimize appropriate surveillance and long-term follow-up.https://www.mdpi.com/2227-9067/9/6/856congenital diaphragmatic hernialong-term outcomesrecurrencepneumoniapneumothoraxgastroesophageal reflux disease |
| spellingShingle | Masaya Yamoto Kouji Nagata Keita Terui Masahiro Hayakawa Hiroomi Okuyama Shoichiro Amari Akiko Yokoi Kouji Masumoto Tadaharu Okazaki Noboru Inamura Katsuaki Toyoshima Yuhki Koike Yuta Yazaki Taizo Furukawa Noriaki Usui Long-Term Outcomes of Congenital Diaphragmatic Hernia: Report of a Multicenter Study in Japan Children congenital diaphragmatic hernia long-term outcomes recurrence pneumonia pneumothorax gastroesophageal reflux disease |
| title | Long-Term Outcomes of Congenital Diaphragmatic Hernia: Report of a Multicenter Study in Japan |
| title_full | Long-Term Outcomes of Congenital Diaphragmatic Hernia: Report of a Multicenter Study in Japan |
| title_fullStr | Long-Term Outcomes of Congenital Diaphragmatic Hernia: Report of a Multicenter Study in Japan |
| title_full_unstemmed | Long-Term Outcomes of Congenital Diaphragmatic Hernia: Report of a Multicenter Study in Japan |
| title_short | Long-Term Outcomes of Congenital Diaphragmatic Hernia: Report of a Multicenter Study in Japan |
| title_sort | long term outcomes of congenital diaphragmatic hernia report of a multicenter study in japan |
| topic | congenital diaphragmatic hernia long-term outcomes recurrence pneumonia pneumothorax gastroesophageal reflux disease |
| url | https://www.mdpi.com/2227-9067/9/6/856 |
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