Immune Response to COVID-19 Vaccination in Frontline Healthcare Workers
This study evaluated the immune response to vaccination against COVID-19 in 534 healthcare frontline workers in Vilnius, Lithuania. The incidence of COVID-19 was reduced significantly after vaccination started in the healthcare sector. SARS-CoV-2 antibodies were detected in groups V–VII and this lev...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/12/2/199 |
| _version_ | 1797296853360836608 |
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| author | Birute Strukcinskiene Zydre Valotkiene Jonas Jurgaitis Rasa Grigoliene Agnieszka Genowska |
| author_facet | Birute Strukcinskiene Zydre Valotkiene Jonas Jurgaitis Rasa Grigoliene Agnieszka Genowska |
| author_sort | Birute Strukcinskiene |
| collection | DOAJ |
| description | This study evaluated the immune response to vaccination against COVID-19 in 534 healthcare frontline workers in Vilnius, Lithuania. The incidence of COVID-19 was reduced significantly after vaccination started in the healthcare sector. SARS-CoV-2 antibodies were detected in groups V–VII and this level of antibodies was found to be effective in preventing COVID-19. Sustained immune response was achieved after two vaccination doses, which remained stable for up to 6 months. After the booster dose, antibody levels remained high for an additional 12 months. Although SARS-CoV-2 antibody levels decreased after 6 months, even lower levels of antibodies provided protection against the Delta strain. The booster dose distributed the antibody titer in the high-level antibody groups, offering maximum protection at 12 months. However, even individuals with high antibody titers were observed to contract COVID-19 after vaccination with a booster dose and 6 months in the presence of the Omicron strain. Unfortunately, high levels of antibodies did not provide protection against the new strain of COVID-19 (the Omicron variant), posing a risk of infection. When comparing the antibody titer of vaccinated participants without COVID-19 and those with COVID-19, the change in antibodies after vaccination was significantly lower in infected participants. Individuals with comorbidities and specific conditions had lower antibody levels. |
| first_indexed | 2024-03-07T22:10:50Z |
| format | Article |
| id | doaj.art-26e60582c08246deab80b2d4d23b8e61 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-07T22:10:50Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-26e60582c08246deab80b2d4d23b8e612024-02-23T15:37:09ZengMDPI AGVaccines2076-393X2024-02-0112219910.3390/vaccines12020199Immune Response to COVID-19 Vaccination in Frontline Healthcare WorkersBirute Strukcinskiene0Zydre Valotkiene1Jonas Jurgaitis2Rasa Grigoliene3Agnieszka Genowska4Faculty of Health Sciences, Klaipeda University, LT-92294 Klaipeda, LithuaniaFaculty of Health Sciences, Klaipeda University, LT-92294 Klaipeda, LithuaniaFaculty of Health Sciences, Klaipeda University, LT-92294 Klaipeda, LithuaniaFaculty of Marine Technologies and Natural Sciences, Klaipeda University, LT-92294 Klaipeda, LithuaniaDepartment of Public Health, Medical University of Bialystok, 15-295 Bialystok, PolandThis study evaluated the immune response to vaccination against COVID-19 in 534 healthcare frontline workers in Vilnius, Lithuania. The incidence of COVID-19 was reduced significantly after vaccination started in the healthcare sector. SARS-CoV-2 antibodies were detected in groups V–VII and this level of antibodies was found to be effective in preventing COVID-19. Sustained immune response was achieved after two vaccination doses, which remained stable for up to 6 months. After the booster dose, antibody levels remained high for an additional 12 months. Although SARS-CoV-2 antibody levels decreased after 6 months, even lower levels of antibodies provided protection against the Delta strain. The booster dose distributed the antibody titer in the high-level antibody groups, offering maximum protection at 12 months. However, even individuals with high antibody titers were observed to contract COVID-19 after vaccination with a booster dose and 6 months in the presence of the Omicron strain. Unfortunately, high levels of antibodies did not provide protection against the new strain of COVID-19 (the Omicron variant), posing a risk of infection. When comparing the antibody titer of vaccinated participants without COVID-19 and those with COVID-19, the change in antibodies after vaccination was significantly lower in infected participants. Individuals with comorbidities and specific conditions had lower antibody levels.https://www.mdpi.com/2076-393X/12/2/199vaccinationimmune responseantibodiesCOVID-19 managementhealthcare sectorfrontline workers |
| spellingShingle | Birute Strukcinskiene Zydre Valotkiene Jonas Jurgaitis Rasa Grigoliene Agnieszka Genowska Immune Response to COVID-19 Vaccination in Frontline Healthcare Workers Vaccines vaccination immune response antibodies COVID-19 management healthcare sector frontline workers |
| title | Immune Response to COVID-19 Vaccination in Frontline Healthcare Workers |
| title_full | Immune Response to COVID-19 Vaccination in Frontline Healthcare Workers |
| title_fullStr | Immune Response to COVID-19 Vaccination in Frontline Healthcare Workers |
| title_full_unstemmed | Immune Response to COVID-19 Vaccination in Frontline Healthcare Workers |
| title_short | Immune Response to COVID-19 Vaccination in Frontline Healthcare Workers |
| title_sort | immune response to covid 19 vaccination in frontline healthcare workers |
| topic | vaccination immune response antibodies COVID-19 management healthcare sector frontline workers |
| url | https://www.mdpi.com/2076-393X/12/2/199 |
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