Fine particulate matter in acute exacerbation of COPD
Chronic obstructive pulmonary disease (COPD) is a common airway disorder. In particular, acute exacerbations of COPD (AECOPD) can significantly reduce pulmonary function. The majority of AECOPD episodes are attributed to infections, although environmental stress also plays a role. Increasing urbaniz...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-10-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00294/full |
| _version_ | 1818176274090164224 |
|---|---|
| author | Lei eNi Chia-Chen eChuang Li eZuo |
| author_facet | Lei eNi Chia-Chen eChuang Li eZuo |
| author_sort | Lei eNi |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) is a common airway disorder. In particular, acute exacerbations of COPD (AECOPD) can significantly reduce pulmonary function. The majority of AECOPD episodes are attributed to infections, although environmental stress also plays a role. Increasing urbanization and associated air pollution, especially in developing countries, have been shown to contribute to COPD pathogenesis. Elevated levels of particulate matter (PM) in polluted air are strongly correlated with the onset and development of various respiratory diseases. In this review, we have conducted an extensive literature search of recent studies of the role of PM2.5 (fine PM) in AECOPD. PM2.5 leads to AECOPD via inflammation, oxidative stress, immune dysfunction, and altered airway epithelial structure and microbiome. Reducing PM2.5 levels is a viable approach to lower AECOPD incidence, attenuate COPD progression and decrease the associated healthcare burden. |
| first_indexed | 2024-12-11T20:13:35Z |
| format | Article |
| id | doaj.art-26e67c5005b14788bb3434703016f89f |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-11T20:13:35Z |
| publishDate | 2015-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-26e67c5005b14788bb3434703016f89f2022-12-22T00:52:14ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2015-10-01610.3389/fphys.2015.00294163183Fine particulate matter in acute exacerbation of COPDLei eNi0Chia-Chen eChuang1Li eZuo2Ruijin Hospital, School of Medicine, Shanghai Jiao Tong UniversityThe Ohio State University College of MedicineThe Ohio State University College of MedicineChronic obstructive pulmonary disease (COPD) is a common airway disorder. In particular, acute exacerbations of COPD (AECOPD) can significantly reduce pulmonary function. The majority of AECOPD episodes are attributed to infections, although environmental stress also plays a role. Increasing urbanization and associated air pollution, especially in developing countries, have been shown to contribute to COPD pathogenesis. Elevated levels of particulate matter (PM) in polluted air are strongly correlated with the onset and development of various respiratory diseases. In this review, we have conducted an extensive literature search of recent studies of the role of PM2.5 (fine PM) in AECOPD. PM2.5 leads to AECOPD via inflammation, oxidative stress, immune dysfunction, and altered airway epithelial structure and microbiome. Reducing PM2.5 levels is a viable approach to lower AECOPD incidence, attenuate COPD progression and decrease the associated healthcare burden.http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00294/fullInflammationOxidative Stressalveolar macrophagesAECOPDPM2.5 |
| spellingShingle | Lei eNi Chia-Chen eChuang Li eZuo Fine particulate matter in acute exacerbation of COPD Frontiers in Physiology Inflammation Oxidative Stress alveolar macrophages AECOPD PM2.5 |
| title | Fine particulate matter in acute exacerbation of COPD |
| title_full | Fine particulate matter in acute exacerbation of COPD |
| title_fullStr | Fine particulate matter in acute exacerbation of COPD |
| title_full_unstemmed | Fine particulate matter in acute exacerbation of COPD |
| title_short | Fine particulate matter in acute exacerbation of COPD |
| title_sort | fine particulate matter in acute exacerbation of copd |
| topic | Inflammation Oxidative Stress alveolar macrophages AECOPD PM2.5 |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00294/full |
| work_keys_str_mv | AT leieni fineparticulatematterinacuteexacerbationofcopd AT chiachenechuang fineparticulatematterinacuteexacerbationofcopd AT liezuo fineparticulatematterinacuteexacerbationofcopd |