An Evaluation of Serum Procalcitonin and C-Reactive Protein Levels as Diagnostic and Prognostic Biomarkers of Severe Sepsis
Background: Recommendations have been made, following the multicenter Surviving Sepsis Campaign study, to standardize the definition of severe sepsis with reference to several parameters such as haemodynamic stability, acid-base balance, bilirubin, creatinine, International Normalized Ratio (INR), u...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2015-10-01
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| Series: | The Journal of Critical Care Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/jccm-2015-0022 |
| _version_ | 1797430311583219712 |
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| author | Szederjesi Janos Almasy Emoke Lazar Alexandra Huțanu Adina Badea Iudita Georgescu Anca |
| author_facet | Szederjesi Janos Almasy Emoke Lazar Alexandra Huțanu Adina Badea Iudita Georgescu Anca |
| author_sort | Szederjesi Janos |
| collection | DOAJ |
| description | Background: Recommendations have been made, following the multicenter Surviving Sepsis Campaign study, to standardize the definition of severe sepsis with reference to several parameters such as haemodynamic stability, acid-base balance, bilirubin, creatinine, International Normalized Ratio (INR), urine output and pulmonary functional value of the ratio between arterial oxigen partial pressure and inspiratory oxigen concentration. Procalcitonin (PCT) is considered to be a gold standard biomarker for the inflammatory response, and recent studies have shown that it may help to discover whether a seriously ill person is developing sepsis. C-reactive protein (CRP) is also used as a marker of inflammation in the body, as its blood levels increase if there is any inflammation in the body. The aim of this study was to evaluate serum procalcitonin and C-reactive protein levels as diagnostic and prognostic biomarkers of severe sepsis. |
| first_indexed | 2024-03-09T09:26:44Z |
| format | Article |
| id | doaj.art-26e88b7949f14f1ebe1648ca1d2390f6 |
| institution | Directory Open Access Journal |
| issn | 2393-1817 |
| language | English |
| last_indexed | 2024-03-09T09:26:44Z |
| publishDate | 2015-10-01 |
| publisher | Sciendo |
| record_format | Article |
| series | The Journal of Critical Care Medicine |
| spelling | doaj.art-26e88b7949f14f1ebe1648ca1d2390f62023-12-02T05:49:45ZengSciendoThe Journal of Critical Care Medicine2393-18172015-10-011414715310.1515/jccm-2015-0022jccm-2015-0022An Evaluation of Serum Procalcitonin and C-Reactive Protein Levels as Diagnostic and Prognostic Biomarkers of Severe SepsisSzederjesi Janos0Almasy Emoke1Lazar Alexandra2Huțanu Adina3Badea Iudita4Georgescu Anca5University of Medicine and Pharmacy Tirgu Mures, Romania, Department of Anesthesiology and Intensive Care, 38 Gheorghe Marinescu, Tirgu MuresUniversity of Medicine and Pharmacy Tirgu Mures, Romania, Department of Anesthesiology and Intensive Care, 38 Gheorghe Marinescu, Tirgu Mures, 540139, RomaniaUniversity of Medicine and Pharmacy Tirgu Mures, Romania, Department of Anesthesiology and Intensive Care, 38 Gheorghe Marinescu, Tirgu Mures, 540139, RomaniaCounty Clinical Emergency Hospital Tirgu Mures, Romania, 50 Gheorghe Marinescu Tirgu Mures, 540139, RomaniaUniversity of Medicine and Pharmacy Tirgu Mures, Romania, Department of Anesthesiology and Intensive Care, 38 Gheorghe Marinescu, Tirgu Mures, 540139, RomaniaUniversity of Medicine and Pharmacy Tirgu Mures, Romania, Department of Infectious Diseases, 38 Gheorghe Marinescu, Tirgu Mures, 540139, RomaniaBackground: Recommendations have been made, following the multicenter Surviving Sepsis Campaign study, to standardize the definition of severe sepsis with reference to several parameters such as haemodynamic stability, acid-base balance, bilirubin, creatinine, International Normalized Ratio (INR), urine output and pulmonary functional value of the ratio between arterial oxigen partial pressure and inspiratory oxigen concentration. Procalcitonin (PCT) is considered to be a gold standard biomarker for the inflammatory response, and recent studies have shown that it may help to discover whether a seriously ill person is developing sepsis. C-reactive protein (CRP) is also used as a marker of inflammation in the body, as its blood levels increase if there is any inflammation in the body. The aim of this study was to evaluate serum procalcitonin and C-reactive protein levels as diagnostic and prognostic biomarkers of severe sepsis.https://doi.org/10.1515/jccm-2015-0022severe sepsisprocalcitoninc-reactive proteinprognostic biomarkers |
| spellingShingle | Szederjesi Janos Almasy Emoke Lazar Alexandra Huțanu Adina Badea Iudita Georgescu Anca An Evaluation of Serum Procalcitonin and C-Reactive Protein Levels as Diagnostic and Prognostic Biomarkers of Severe Sepsis The Journal of Critical Care Medicine severe sepsis procalcitonin c-reactive protein prognostic biomarkers |
| title | An Evaluation of Serum Procalcitonin and C-Reactive Protein Levels as Diagnostic and Prognostic Biomarkers of Severe Sepsis |
| title_full | An Evaluation of Serum Procalcitonin and C-Reactive Protein Levels as Diagnostic and Prognostic Biomarkers of Severe Sepsis |
| title_fullStr | An Evaluation of Serum Procalcitonin and C-Reactive Protein Levels as Diagnostic and Prognostic Biomarkers of Severe Sepsis |
| title_full_unstemmed | An Evaluation of Serum Procalcitonin and C-Reactive Protein Levels as Diagnostic and Prognostic Biomarkers of Severe Sepsis |
| title_short | An Evaluation of Serum Procalcitonin and C-Reactive Protein Levels as Diagnostic and Prognostic Biomarkers of Severe Sepsis |
| title_sort | evaluation of serum procalcitonin and c reactive protein levels as diagnostic and prognostic biomarkers of severe sepsis |
| topic | severe sepsis procalcitonin c-reactive protein prognostic biomarkers |
| url | https://doi.org/10.1515/jccm-2015-0022 |
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