Scleral Thickness as a Risk Factor for Central Serous Chorioretinopathy and Pachychoroid Neovasculopathy
In the pathophysiology of central serous chorioretinopathy (CSC), scleral changes inducing increased venous outflow resistance are hypothesized to be involved. This work aims to investigate anterior scleral thickness (AST) as a risk factor for pachychoroid disorders. A randomized prospective case-co...
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MDPI AG
2023-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/9/3102 |
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| author | Leonie F. Keidel Benedikt Schworm Julian Langer Nikolaus Luft Tina Herold Felix Hagenau Julian E. Klaas Siegfried G. Priglinger Jakob Siedlecki |
| author_facet | Leonie F. Keidel Benedikt Schworm Julian Langer Nikolaus Luft Tina Herold Felix Hagenau Julian E. Klaas Siegfried G. Priglinger Jakob Siedlecki |
| author_sort | Leonie F. Keidel |
| collection | DOAJ |
| description | In the pathophysiology of central serous chorioretinopathy (CSC), scleral changes inducing increased venous outflow resistance are hypothesized to be involved. This work aims to investigate anterior scleral thickness (AST) as a risk factor for pachychoroid disorders. A randomized prospective case-control study was performed at the Ludwig Maximilians University, Department of Ophthalmology. In patients with CSC or pachychoroid neovasculopathy (PNV) and in an age- and refraction-matched control group, swept source optical coherence tomography (SS-OCT) was used to measure anterior scleral thickness (AST). Subfoveal choroidal thickness (SFCT) was assessed using enhanced depth imaging OCT (EDI-OCT). In total, 46 eyes of 46 patients were included in this study, with 23 eyes in the CSC/PNV and 23 eyes in the control group. A significantly higher AST was found in the CSC/PNV compared with the control group (403.5 ± 68.6 (278 to 619) vs. 362.5 ± 62.6 (218 to 498) µm; <i>p</i> = 0.028). Moreover, the CSC/PNV group showed a higher SFCT (392.8 ± 92.8 (191–523) vs. 330.95 ± 116.5 (167–609) µm, <i>p</i> = 0.004). Compared with the age- and refraction-matched controls, patients with CSC and PNV showed a significantly thicker anterior sclera. Scleral thickness might contribute to the venous overload hypothesized to induce pachychoroid phenotypes. |
| first_indexed | 2024-03-11T04:14:58Z |
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| language | English |
| last_indexed | 2024-03-11T04:14:58Z |
| publishDate | 2023-04-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-26ea33a28bd2414e9693c27eb3b4810b2023-11-17T23:10:45ZengMDPI AGJournal of Clinical Medicine2077-03832023-04-01129310210.3390/jcm12093102Scleral Thickness as a Risk Factor for Central Serous Chorioretinopathy and Pachychoroid NeovasculopathyLeonie F. Keidel0Benedikt Schworm1Julian Langer2Nikolaus Luft3Tina Herold4Felix Hagenau5Julian E. Klaas6Siegfried G. Priglinger7Jakob Siedlecki8Department of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, GermanyDepartment of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, GermanyDepartment of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, GermanyDepartment of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, GermanyDepartment of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, GermanyDepartment of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, GermanyDepartment of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, GermanyDepartment of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, GermanyDepartment of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, GermanyIn the pathophysiology of central serous chorioretinopathy (CSC), scleral changes inducing increased venous outflow resistance are hypothesized to be involved. This work aims to investigate anterior scleral thickness (AST) as a risk factor for pachychoroid disorders. A randomized prospective case-control study was performed at the Ludwig Maximilians University, Department of Ophthalmology. In patients with CSC or pachychoroid neovasculopathy (PNV) and in an age- and refraction-matched control group, swept source optical coherence tomography (SS-OCT) was used to measure anterior scleral thickness (AST). Subfoveal choroidal thickness (SFCT) was assessed using enhanced depth imaging OCT (EDI-OCT). In total, 46 eyes of 46 patients were included in this study, with 23 eyes in the CSC/PNV and 23 eyes in the control group. A significantly higher AST was found in the CSC/PNV compared with the control group (403.5 ± 68.6 (278 to 619) vs. 362.5 ± 62.6 (218 to 498) µm; <i>p</i> = 0.028). Moreover, the CSC/PNV group showed a higher SFCT (392.8 ± 92.8 (191–523) vs. 330.95 ± 116.5 (167–609) µm, <i>p</i> = 0.004). Compared with the age- and refraction-matched controls, patients with CSC and PNV showed a significantly thicker anterior sclera. Scleral thickness might contribute to the venous overload hypothesized to induce pachychoroid phenotypes.https://www.mdpi.com/2077-0383/12/9/3102pachychoroidpachyscleraswept-source optical coherence tomographyanterior scleral thicknesscentral serous chorioretinopathypachychoroid neovascularisation |
| spellingShingle | Leonie F. Keidel Benedikt Schworm Julian Langer Nikolaus Luft Tina Herold Felix Hagenau Julian E. Klaas Siegfried G. Priglinger Jakob Siedlecki Scleral Thickness as a Risk Factor for Central Serous Chorioretinopathy and Pachychoroid Neovasculopathy Journal of Clinical Medicine pachychoroid pachysclera swept-source optical coherence tomography anterior scleral thickness central serous chorioretinopathy pachychoroid neovascularisation |
| title | Scleral Thickness as a Risk Factor for Central Serous Chorioretinopathy and Pachychoroid Neovasculopathy |
| title_full | Scleral Thickness as a Risk Factor for Central Serous Chorioretinopathy and Pachychoroid Neovasculopathy |
| title_fullStr | Scleral Thickness as a Risk Factor for Central Serous Chorioretinopathy and Pachychoroid Neovasculopathy |
| title_full_unstemmed | Scleral Thickness as a Risk Factor for Central Serous Chorioretinopathy and Pachychoroid Neovasculopathy |
| title_short | Scleral Thickness as a Risk Factor for Central Serous Chorioretinopathy and Pachychoroid Neovasculopathy |
| title_sort | scleral thickness as a risk factor for central serous chorioretinopathy and pachychoroid neovasculopathy |
| topic | pachychoroid pachysclera swept-source optical coherence tomography anterior scleral thickness central serous chorioretinopathy pachychoroid neovascularisation |
| url | https://www.mdpi.com/2077-0383/12/9/3102 |
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