Pregestational diabetes mediates the association between maternal obesity and the risk of congenital heart defects
Abstract Aims/Introduction We aimed to explore whether the association between obesity and congenital heart defects (CHDs) can be mediated by maternal pregestational diabetes (PGDM). Materials and Methods We included 53,708 mother‐infant pairs with deliveries between 2017 and 2019 from the Birth Coh...
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| Format: | Article |
| Language: | English |
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Wiley
2022-02-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.13666 |
| _version_ | 1819281155960078336 |
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| author | Xiao‐Xia Wu Ru‐Xiu Ge Le Huang Fu‐Ying Tian Yi‐Xuan Chen Lin‐Lin Wu Jian‐Min Niu |
| author_facet | Xiao‐Xia Wu Ru‐Xiu Ge Le Huang Fu‐Ying Tian Yi‐Xuan Chen Lin‐Lin Wu Jian‐Min Niu |
| author_sort | Xiao‐Xia Wu |
| collection | DOAJ |
| description | Abstract Aims/Introduction We aimed to explore whether the association between obesity and congenital heart defects (CHDs) can be mediated by maternal pregestational diabetes (PGDM). Materials and Methods We included 53,708 mother‐infant pairs with deliveries between 2017 and 2019 from the Birth Cohort in Shenzhen. Mothers were categorized into four groups: the underweight group (body mass index [BMI] <18.5), normal weight group (18.5 ≤ BMI < 24), overweight group (24 ≤ BMI < 28) and obesity group (BMI ≥28). Multivariable logistic regression models were used to evaluate the association between BMI and CHDs. Mediation analysis was used to confirm the effect of PGDM on the association between maternal obesity and CHDs. Results The proportion of obese individuals in the Birth Cohort in Shenzhen was 2.11%. Overall, 372 (0.69%) infants were diagnosed with CHDs. Maternal obesity was associated with an increased risk of CHDs (odds ratio 1.97, 95% confidence interval 1.14–3.41). The mediation effect of PGDM on the association between maternal obesity and CHDs was significant (odds ratio 1.18, 95% confidence interval 1.06–1.32). The estimated mediation proportion was 24.83%. Conclusions Maternal obesity was associated with increased risk for CHDs, and PGDM partially mediated the association between maternal obesity and CHDs. |
| first_indexed | 2024-12-24T00:55:12Z |
| format | Article |
| id | doaj.art-26eadc5bbd644ab681409bb0ca38447a |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-12-24T00:55:12Z |
| publishDate | 2022-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-26eadc5bbd644ab681409bb0ca38447a2022-12-21T17:23:29ZengWileyJournal of Diabetes Investigation2040-11162040-11242022-02-0113236737410.1111/jdi.13666Pregestational diabetes mediates the association between maternal obesity and the risk of congenital heart defectsXiao‐Xia Wu0Ru‐Xiu Ge1Le Huang2Fu‐Ying Tian3Yi‐Xuan Chen4Lin‐Lin Wu5Jian‐Min Niu6Department of Obstetrics Cheeloo College of Medicine Shenzhen Maternity and Child Healthcare Hospital Shandong University Shenzhen, Guangdong ChinaDepartment of Obstetrics Cheeloo College of Medicine Shenzhen Maternity and Child Healthcare Hospital Shandong University Shenzhen, Guangdong ChinaDepartment of Obstetrics Cheeloo College of Medicine Shenzhen Maternity and Child Healthcare Hospital Shandong University Shenzhen, Guangdong ChinaDepartment of Obstetrics Cheeloo College of Medicine Shenzhen Maternity and Child Healthcare Hospital Shandong University Shenzhen, Guangdong ChinaDepartment of Obstetrics Cheeloo College of Medicine Shenzhen Maternity and Child Healthcare Hospital Shandong University Shenzhen, Guangdong ChinaDepartment of Obstetrics Cheeloo College of Medicine Shenzhen Maternity and Child Healthcare Hospital Shandong University Shenzhen, Guangdong ChinaDepartment of Obstetrics Cheeloo College of Medicine Shenzhen Maternity and Child Healthcare Hospital Shandong University Shenzhen, Guangdong ChinaAbstract Aims/Introduction We aimed to explore whether the association between obesity and congenital heart defects (CHDs) can be mediated by maternal pregestational diabetes (PGDM). Materials and Methods We included 53,708 mother‐infant pairs with deliveries between 2017 and 2019 from the Birth Cohort in Shenzhen. Mothers were categorized into four groups: the underweight group (body mass index [BMI] <18.5), normal weight group (18.5 ≤ BMI < 24), overweight group (24 ≤ BMI < 28) and obesity group (BMI ≥28). Multivariable logistic regression models were used to evaluate the association between BMI and CHDs. Mediation analysis was used to confirm the effect of PGDM on the association between maternal obesity and CHDs. Results The proportion of obese individuals in the Birth Cohort in Shenzhen was 2.11%. Overall, 372 (0.69%) infants were diagnosed with CHDs. Maternal obesity was associated with an increased risk of CHDs (odds ratio 1.97, 95% confidence interval 1.14–3.41). The mediation effect of PGDM on the association between maternal obesity and CHDs was significant (odds ratio 1.18, 95% confidence interval 1.06–1.32). The estimated mediation proportion was 24.83%. Conclusions Maternal obesity was associated with increased risk for CHDs, and PGDM partially mediated the association between maternal obesity and CHDs.https://doi.org/10.1111/jdi.13666Congenital heart defectObesityPregestational diabetes |
| spellingShingle | Xiao‐Xia Wu Ru‐Xiu Ge Le Huang Fu‐Ying Tian Yi‐Xuan Chen Lin‐Lin Wu Jian‐Min Niu Pregestational diabetes mediates the association between maternal obesity and the risk of congenital heart defects Journal of Diabetes Investigation Congenital heart defect Obesity Pregestational diabetes |
| title | Pregestational diabetes mediates the association between maternal obesity and the risk of congenital heart defects |
| title_full | Pregestational diabetes mediates the association between maternal obesity and the risk of congenital heart defects |
| title_fullStr | Pregestational diabetes mediates the association between maternal obesity and the risk of congenital heart defects |
| title_full_unstemmed | Pregestational diabetes mediates the association between maternal obesity and the risk of congenital heart defects |
| title_short | Pregestational diabetes mediates the association between maternal obesity and the risk of congenital heart defects |
| title_sort | pregestational diabetes mediates the association between maternal obesity and the risk of congenital heart defects |
| topic | Congenital heart defect Obesity Pregestational diabetes |
| url | https://doi.org/10.1111/jdi.13666 |
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