A meta-analysis of cohort and pilot studies indicates association of mouthwash use and risk of hypertension in adults
The relationship between high blood pressure (hypertension) incidence and mouthwash use is a subject of ongoing research. Origin of this link may lie in mouthwash-mediated destruction of oral microflora, and consequently reduced nitric oxide (NO) bioavailability. In this study, we evaluated the asso...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-05-01
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| Series: | Journal of King Saud University: Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1018364724000958 |
| _version_ | 1827284828836331520 |
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| author | Hala Abubaker Bagabir Rgad Bagabir Ayman K. Johargy Hani Faidah Ahmad O. Babalghith Farkad Bantun Faraz Ahmad Darin Mansor Mathkor Shafiul Haque |
| author_facet | Hala Abubaker Bagabir Rgad Bagabir Ayman K. Johargy Hani Faidah Ahmad O. Babalghith Farkad Bantun Faraz Ahmad Darin Mansor Mathkor Shafiul Haque |
| author_sort | Hala Abubaker Bagabir |
| collection | DOAJ |
| description | The relationship between high blood pressure (hypertension) incidence and mouthwash use is a subject of ongoing research. Origin of this link may lie in mouthwash-mediated destruction of oral microflora, and consequently reduced nitric oxide (NO) bioavailability. In this study, we evaluated the association between mouthwash use and the risk of hypertension through statistical meta-analysis of published cohort and cross-sectional studies. The search strategy and selection of research articles was in accord with PRISMA guidelines, and under pre-defined set of inclusion criteria. Primary research studies focused on “association among use of mouthwash and risk of hypertension incidence” were searched on databases such as PubMed, EMBASE, MEDLINE, and Cochrane Library. MesH keywords such as “hypertension”, “mouthwash use”, “risk of HTN”, “HTN incidence”, “nitric oxide bioavailability”, and “cohort studies” were used. Out of 1650 studies, 9 met all the inclusion criteria and were finally selected. RevMan 5.3 software was employed for statistical analyses of data retrieved from these selected studies. About 6384 adults with mild hypertension symptoms were included in this meta-analysis from different cohort, pilot and cross-sectional studies. All participants’ ages ranged between 40 and 60 years with mild symptoms of hypertension. While high statistical heterogeneity was observed, our results indicate a significant association of antiseptic mouthwash use with the risk of developing hypertension. The findings reveal a slightly but significantly elevated risk of development of hypertension among regular antiseptic mouthwash users, in comparison to non-users. However, further studies are needed to confirm and establish this relationship further. |
| first_indexed | 2024-04-24T10:03:53Z |
| format | Article |
| id | doaj.art-26eda9ecacdb4b5bb982948e0a27c0fe |
| institution | Directory Open Access Journal |
| issn | 1018-3647 |
| language | English |
| last_indexed | 2024-04-24T10:03:53Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of King Saud University: Science |
| spelling | doaj.art-26eda9ecacdb4b5bb982948e0a27c0fe2024-04-13T04:21:02ZengElsevierJournal of King Saud University: Science1018-36472024-05-01365103183A meta-analysis of cohort and pilot studies indicates association of mouthwash use and risk of hypertension in adultsHala Abubaker Bagabir0Rgad Bagabir1Ayman K. Johargy2Hani Faidah3Ahmad O. Babalghith4Farkad Bantun5Faraz Ahmad6Darin Mansor Mathkor7Shafiul Haque8Physiology Department, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Saudi ArabiaDepartment of Dental Services, King Abdulaziz Medical City, Jeddah, Saudi ArabiaDepartment of Microbiology and Parasitology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi ArabiaDepartment of Microbiology and Parasitology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi ArabiaDepartment of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi ArabiaDepartment of Microbiology and Parasitology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi ArabiaDepartment of Biotechnology, School of Bio Sciences and Technology (SBST), Vellore Institute of Technology (VIT), Vellore 632014, India; Corresponding authors at: Department of Biotechnology, School of Bio Sciences and Technology (SBST), Vellore Institute of Technology (VIT), Vellore 632014, India (F. Ahmad). Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia (S. Haque).Research and Scientific Studies Unit, College of Nursing and Health Sciences, Jazan University, Jazan-45142, Saudi ArabiaResearch and Scientific Studies Unit, College of Nursing and Health Sciences, Jazan University, Jazan-45142, Saudi Arabia; Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut 1102 2801, Lebanon; Corresponding authors at: Department of Biotechnology, School of Bio Sciences and Technology (SBST), Vellore Institute of Technology (VIT), Vellore 632014, India (F. Ahmad). Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia (S. Haque).The relationship between high blood pressure (hypertension) incidence and mouthwash use is a subject of ongoing research. Origin of this link may lie in mouthwash-mediated destruction of oral microflora, and consequently reduced nitric oxide (NO) bioavailability. In this study, we evaluated the association between mouthwash use and the risk of hypertension through statistical meta-analysis of published cohort and cross-sectional studies. The search strategy and selection of research articles was in accord with PRISMA guidelines, and under pre-defined set of inclusion criteria. Primary research studies focused on “association among use of mouthwash and risk of hypertension incidence” were searched on databases such as PubMed, EMBASE, MEDLINE, and Cochrane Library. MesH keywords such as “hypertension”, “mouthwash use”, “risk of HTN”, “HTN incidence”, “nitric oxide bioavailability”, and “cohort studies” were used. Out of 1650 studies, 9 met all the inclusion criteria and were finally selected. RevMan 5.3 software was employed for statistical analyses of data retrieved from these selected studies. About 6384 adults with mild hypertension symptoms were included in this meta-analysis from different cohort, pilot and cross-sectional studies. All participants’ ages ranged between 40 and 60 years with mild symptoms of hypertension. While high statistical heterogeneity was observed, our results indicate a significant association of antiseptic mouthwash use with the risk of developing hypertension. The findings reveal a slightly but significantly elevated risk of development of hypertension among regular antiseptic mouthwash users, in comparison to non-users. However, further studies are needed to confirm and establish this relationship further.http://www.sciencedirect.com/science/article/pii/S1018364724000958MouthwashHypertensionNitric oxideMicrofloraMeta-analysis |
| spellingShingle | Hala Abubaker Bagabir Rgad Bagabir Ayman K. Johargy Hani Faidah Ahmad O. Babalghith Farkad Bantun Faraz Ahmad Darin Mansor Mathkor Shafiul Haque A meta-analysis of cohort and pilot studies indicates association of mouthwash use and risk of hypertension in adults Journal of King Saud University: Science Mouthwash Hypertension Nitric oxide Microflora Meta-analysis |
| title | A meta-analysis of cohort and pilot studies indicates association of mouthwash use and risk of hypertension in adults |
| title_full | A meta-analysis of cohort and pilot studies indicates association of mouthwash use and risk of hypertension in adults |
| title_fullStr | A meta-analysis of cohort and pilot studies indicates association of mouthwash use and risk of hypertension in adults |
| title_full_unstemmed | A meta-analysis of cohort and pilot studies indicates association of mouthwash use and risk of hypertension in adults |
| title_short | A meta-analysis of cohort and pilot studies indicates association of mouthwash use and risk of hypertension in adults |
| title_sort | meta analysis of cohort and pilot studies indicates association of mouthwash use and risk of hypertension in adults |
| topic | Mouthwash Hypertension Nitric oxide Microflora Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S1018364724000958 |
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