Eight Orthostatic Haemodynamic Patterns in The Irish Longitudinal Study on Ageing (TILDA): Stability and Clinical Associations after 4 Years
Previous research cross-sectionally characterised eight morphological systolic blood pressure (SBP) active stand (AS) patterns using a clinical clustering approach at Wave 1 (W1) of the Irish Longitudinal Study on Ageing. We explored the longitudinal stability and clinical associations of these grou...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Geriatrics |
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| Online Access: | https://www.mdpi.com/2308-3417/6/2/50 |
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| author | David Moloney Silvin P. Knight Louise Newman Rose Anne Kenny Roman Romero-Ortuno |
| author_facet | David Moloney Silvin P. Knight Louise Newman Rose Anne Kenny Roman Romero-Ortuno |
| author_sort | David Moloney |
| collection | DOAJ |
| description | Previous research cross-sectionally characterised eight morphological systolic blood pressure (SBP) active stand (AS) patterns using a clinical clustering approach at Wave 1 (W1) of the Irish Longitudinal Study on Ageing. We explored the longitudinal stability and clinical associations of these groupings at Wave 3 (W3), four years later. Eight AS groups had their clinical characteristics and AS patterns at W3 compared to W1. We explored longitudinal associations (new cognitive decline, falls, syncope, disability, and mortality) using multivariate logistic regression models. In total, 2938 participants (60% of Wave 1 sample) had adequate AS data from both W1 and 3 for analysis. We found no longitudinal stability of the eight AS groups or their morphological patterns between the waves. A pattern of impaired stabilisation and late deficit seemed more preserved and was seen in association with new cognitive decline (OR 1.63, 95% CI: 1.12–2.36, <i>p</i> = 0.011). An increase in antihypertensive usage seemed associated with reduced immediate SBP drops, improved AS patterns, and reduced orthostatic intolerance (OI). In pure longitudinal groups, AS patterns were not preserved after 4 years. AS patterns are longitudinally dynamic, and improvements after 4 years are possible even in the presence of higher antihypertensive burden. |
| first_indexed | 2024-03-10T11:31:26Z |
| format | Article |
| id | doaj.art-26f091489135425c8965383a4597a9e5 |
| institution | Directory Open Access Journal |
| issn | 2308-3417 |
| language | English |
| last_indexed | 2024-03-10T11:31:26Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Geriatrics |
| spelling | doaj.art-26f091489135425c8965383a4597a9e52023-11-21T19:10:10ZengMDPI AGGeriatrics2308-34172021-05-01625010.3390/geriatrics6020050Eight Orthostatic Haemodynamic Patterns in The Irish Longitudinal Study on Ageing (TILDA): Stability and Clinical Associations after 4 YearsDavid Moloney0Silvin P. Knight1Louise Newman2Rose Anne Kenny3Roman Romero-Ortuno4The Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, D02 R590 Dublin, IrelandThe Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, D02 R590 Dublin, IrelandThe Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, D02 R590 Dublin, IrelandThe Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, D02 R590 Dublin, IrelandThe Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, D02 R590 Dublin, IrelandPrevious research cross-sectionally characterised eight morphological systolic blood pressure (SBP) active stand (AS) patterns using a clinical clustering approach at Wave 1 (W1) of the Irish Longitudinal Study on Ageing. We explored the longitudinal stability and clinical associations of these groupings at Wave 3 (W3), four years later. Eight AS groups had their clinical characteristics and AS patterns at W3 compared to W1. We explored longitudinal associations (new cognitive decline, falls, syncope, disability, and mortality) using multivariate logistic regression models. In total, 2938 participants (60% of Wave 1 sample) had adequate AS data from both W1 and 3 for analysis. We found no longitudinal stability of the eight AS groups or their morphological patterns between the waves. A pattern of impaired stabilisation and late deficit seemed more preserved and was seen in association with new cognitive decline (OR 1.63, 95% CI: 1.12–2.36, <i>p</i> = 0.011). An increase in antihypertensive usage seemed associated with reduced immediate SBP drops, improved AS patterns, and reduced orthostatic intolerance (OI). In pure longitudinal groups, AS patterns were not preserved after 4 years. AS patterns are longitudinally dynamic, and improvements after 4 years are possible even in the presence of higher antihypertensive burden.https://www.mdpi.com/2308-3417/6/2/50orthostatic hypotensionfallssyncopelongitudinalphysiological monitoring |
| spellingShingle | David Moloney Silvin P. Knight Louise Newman Rose Anne Kenny Roman Romero-Ortuno Eight Orthostatic Haemodynamic Patterns in The Irish Longitudinal Study on Ageing (TILDA): Stability and Clinical Associations after 4 Years Geriatrics orthostatic hypotension falls syncope longitudinal physiological monitoring |
| title | Eight Orthostatic Haemodynamic Patterns in The Irish Longitudinal Study on Ageing (TILDA): Stability and Clinical Associations after 4 Years |
| title_full | Eight Orthostatic Haemodynamic Patterns in The Irish Longitudinal Study on Ageing (TILDA): Stability and Clinical Associations after 4 Years |
| title_fullStr | Eight Orthostatic Haemodynamic Patterns in The Irish Longitudinal Study on Ageing (TILDA): Stability and Clinical Associations after 4 Years |
| title_full_unstemmed | Eight Orthostatic Haemodynamic Patterns in The Irish Longitudinal Study on Ageing (TILDA): Stability and Clinical Associations after 4 Years |
| title_short | Eight Orthostatic Haemodynamic Patterns in The Irish Longitudinal Study on Ageing (TILDA): Stability and Clinical Associations after 4 Years |
| title_sort | eight orthostatic haemodynamic patterns in the irish longitudinal study on ageing tilda stability and clinical associations after 4 years |
| topic | orthostatic hypotension falls syncope longitudinal physiological monitoring |
| url | https://www.mdpi.com/2308-3417/6/2/50 |
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