Multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathy
Purpose: To investigate the effect of optic neuritis (ON), ischemic optic neuropathy (ION) and compressive optic neuropathy (CON) on multifocal visual evoked potential (mfVEP) amplitudes and latencies, and to compare the parameters among three optic nerve disorders. Materials and Methods: mfVEP was...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2014;volume=62;issue=3;spage=299;epage=304;aulast=Jayaraman |
| _version_ | 1811194257967415296 |
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| author | Manju Jayaraman Rashmin Anilkumar Gandhi Priya Ravi Parveen Sen |
| author_facet | Manju Jayaraman Rashmin Anilkumar Gandhi Priya Ravi Parveen Sen |
| author_sort | Manju Jayaraman |
| collection | DOAJ |
| description | Purpose: To investigate the effect of optic neuritis (ON), ischemic optic neuropathy (ION) and compressive optic neuropathy (CON) on multifocal visual evoked potential (mfVEP) amplitudes and latencies, and to compare the parameters among three optic nerve disorders. Materials and Methods: mfVEP was recorded for 71 eyes of controls and 48 eyes of optic nerve disorders with subgroups of optic neuritis (ON, n = 21 eyes), ischemic optic neuropathy (ION, n = 14 eyes), and compressive optic neuropathy (CON, n = 13 eyes). The size of defect in mfVEP amplitude probability plots and relative latency plots were analyzed. The pattern of the defect in amplitude probability plot was classified according to the visual field profile of optic neuritis treatment trail (ONTT). Results: Median of mfVEP amplitude (log SNR) averaged across 60 sectors were reduced in ON (0.17 (0.13-0.33)), ION (0.14 (0.12-0.21)) and CON (0.21 (0.14-0.30)) when compared to controls. The median mfVEP relative latencies compared to controls were significantly prolonged in ON and CON group of 10.53 (2.62-15.50) ms and 5.73 (2.67-14.14) ms respectively compared to ION group (2.06 (-4.09-13.02)). The common mfVEP amplitude defects observed in probability plots were diffuse pattern in ON, inferior altitudinal defect in ION and temporal hemianopia in CON eyes. Conclusions: Optic nerve disorders cause reduction in mfVEP amplitudes. The extent of delayed latency noted in ischemic optic neuropathy was significantly lesser compared to subjects with optic neuritis and compressive optic neuropathy. mfVEP amplitudes can be used to objectively assess the topography of the visual field defect. |
| first_indexed | 2024-04-12T00:23:03Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-04-12T00:23:03Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-26f10f91b16844c99395ce41cc52463f2022-12-22T03:55:37ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892014-01-0162329930410.4103/0301-4738.118452Multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathyManju JayaramanRashmin Anilkumar GandhiPriya RaviParveen SenPurpose: To investigate the effect of optic neuritis (ON), ischemic optic neuropathy (ION) and compressive optic neuropathy (CON) on multifocal visual evoked potential (mfVEP) amplitudes and latencies, and to compare the parameters among three optic nerve disorders. Materials and Methods: mfVEP was recorded for 71 eyes of controls and 48 eyes of optic nerve disorders with subgroups of optic neuritis (ON, n = 21 eyes), ischemic optic neuropathy (ION, n = 14 eyes), and compressive optic neuropathy (CON, n = 13 eyes). The size of defect in mfVEP amplitude probability plots and relative latency plots were analyzed. The pattern of the defect in amplitude probability plot was classified according to the visual field profile of optic neuritis treatment trail (ONTT). Results: Median of mfVEP amplitude (log SNR) averaged across 60 sectors were reduced in ON (0.17 (0.13-0.33)), ION (0.14 (0.12-0.21)) and CON (0.21 (0.14-0.30)) when compared to controls. The median mfVEP relative latencies compared to controls were significantly prolonged in ON and CON group of 10.53 (2.62-15.50) ms and 5.73 (2.67-14.14) ms respectively compared to ION group (2.06 (-4.09-13.02)). The common mfVEP amplitude defects observed in probability plots were diffuse pattern in ON, inferior altitudinal defect in ION and temporal hemianopia in CON eyes. Conclusions: Optic nerve disorders cause reduction in mfVEP amplitudes. The extent of delayed latency noted in ischemic optic neuropathy was significantly lesser compared to subjects with optic neuritis and compressive optic neuropathy. mfVEP amplitudes can be used to objectively assess the topography of the visual field defect.http://www.ijo.in/article.asp?issn=0301-4738;year=2014;volume=62;issue=3;spage=299;epage=304;aulast=Jayaraman Clinical profileIndian populationoptic neuritis treatment trialoptic neuritis Decompression of the orbitdiplopiaorbitthyroid exophthalmosthyroid ophthalmopathy Limbus incisionsubconjunctival incisionsutureless manual small-incision cataract surgerywound constructionCentral retinal vein occlusionintravitrealbevacizumabintravitrealtriamcinolone acetonidemacular edema Contrast sensitivityfixationmicroperimeternormative dataretinal sensitivity Optical coherence tomographyoptic disc pitretinal detachmentretinoschisis Homocysteineretinal vein occlusionvisual impairment Diabetic macular edemamonocyte chemoattractant protein-1soluble intracellular adhesion molecule-1vascular endothelial growth factorCompressive optic neuropathyhumphrey visual fieldischemic optic neuropathymultifocal visual evoked potentialoptic neuritis |
| spellingShingle | Manju Jayaraman Rashmin Anilkumar Gandhi Priya Ravi Parveen Sen Multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathy Indian Journal of Ophthalmology Clinical profile Indian population optic neuritis treatment trial optic neuritis Decompression of the orbit diplopia orbit thyroid exophthalmos thyroid ophthalmopathy Limbus incision subconjunctival incision sutureless manual small-incision cataract surgery wound construction Central retinal vein occlusion intravitrealbevacizumab intravitrealtriamcinolone acetonide macular edema Contrast sensitivity fixation microperimeter normative data retinal sensitivity Optical coherence tomography optic disc pit retinal detachment retinoschisis Homocysteine retinal vein occlusion visual impairment Diabetic macular edema monocyte chemoattractant protein-1 soluble intracellular adhesion molecule-1 vascular endothelial growth factor Compressive optic neuropathy humphrey visual field ischemic optic neuropathy multifocal visual evoked potential optic neuritis |
| title | Multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathy |
| title_full | Multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathy |
| title_fullStr | Multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathy |
| title_full_unstemmed | Multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathy |
| title_short | Multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathy |
| title_sort | multifocal visual evoked potential in optic neuritis ischemic optic neuropathy and compressive optic neuropathy |
| topic | Clinical profile Indian population optic neuritis treatment trial optic neuritis Decompression of the orbit diplopia orbit thyroid exophthalmos thyroid ophthalmopathy Limbus incision subconjunctival incision sutureless manual small-incision cataract surgery wound construction Central retinal vein occlusion intravitrealbevacizumab intravitrealtriamcinolone acetonide macular edema Contrast sensitivity fixation microperimeter normative data retinal sensitivity Optical coherence tomography optic disc pit retinal detachment retinoschisis Homocysteine retinal vein occlusion visual impairment Diabetic macular edema monocyte chemoattractant protein-1 soluble intracellular adhesion molecule-1 vascular endothelial growth factor Compressive optic neuropathy humphrey visual field ischemic optic neuropathy multifocal visual evoked potential optic neuritis |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2014;volume=62;issue=3;spage=299;epage=304;aulast=Jayaraman |
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