Mitochondrial impairment and repair in the pathogenesis of systemic lupus erythematosus

Mitochondrial impairment and repair in the pathogenesis of systemic lupus erythematosus

Nucleic acid autoantibodies, increase type I interferon (IFN-α) levels, and immune cell hyperactivation are hallmarks of systemic lupus erythematosus (SLE). Notably, immune cell activation requires high level of cellular energy that is predominately generated by the mitochondria. Mitochondrial react...

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Bibliographic Details
Main Authors: Like Zhao, Xianda Hu, Fei Xiao, Xuan Zhang, Lidan Zhao, Min Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
mitochondrial reactive oxygen species
mitochondrial dysfunction
mitophagy
oxidative stress
mitochondria targeting therapeutics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.929520/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.929520/full

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