Engineering multifunctional bioactive citrate-based biomaterials for tissue engineering
Developing bioactive biomaterials with highly controlled functions is crucial to enhancing their applications in regenerative medicine. Citrate-based polymers are the few bioactive polymer biomaterials used in biomedicine because of their facile synthesis, controllable structure, biocompatibility, b...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-01-01
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| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X22002043 |
| _version_ | 1798000768861601792 |
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| author | Min Wang Peng Xu Bo Lei |
| author_facet | Min Wang Peng Xu Bo Lei |
| author_sort | Min Wang |
| collection | DOAJ |
| description | Developing bioactive biomaterials with highly controlled functions is crucial to enhancing their applications in regenerative medicine. Citrate-based polymers are the few bioactive polymer biomaterials used in biomedicine because of their facile synthesis, controllable structure, biocompatibility, biomimetic viscoelastic mechanical behavior, and functional groups available for modification. In recent years, various multifunctional designs and biomedical applications, including cardiovascular, orthopedic, muscle tissue, skin tissue, nerve and spinal cord, bioimaging, and drug or gene delivery based on citrate-based polymers, have been extensively studied, and many of them have good clinical application potential. In this review, we summarize recent progress in the multifunctional design and biomedical applications of citrate-based polymers. We also discuss the further development of multifunctional citrate-based polymers with tailored properties to meet the requirements of various biomedical applications. |
| first_indexed | 2024-04-11T11:25:39Z |
| format | Article |
| id | doaj.art-26f2d87b3ccf4857ae26b4b3f9b7bfda |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-11T11:25:39Z |
| publishDate | 2023-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-26f2d87b3ccf4857ae26b4b3f9b7bfda2022-12-22T04:26:17ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-01-0119511537Engineering multifunctional bioactive citrate-based biomaterials for tissue engineeringMin Wang0Peng Xu1Bo Lei2Honghui Hospital, Xi'an Jiaotong University, Xi'an, 710000, ChinaHonghui Hospital, Xi'an Jiaotong University, Xi'an, 710000, China; Corresponding author.Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710000, China; Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710000, China; State-Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710000, China; State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an, 710000, China; Corresponding author. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710000, China.Developing bioactive biomaterials with highly controlled functions is crucial to enhancing their applications in regenerative medicine. Citrate-based polymers are the few bioactive polymer biomaterials used in biomedicine because of their facile synthesis, controllable structure, biocompatibility, biomimetic viscoelastic mechanical behavior, and functional groups available for modification. In recent years, various multifunctional designs and biomedical applications, including cardiovascular, orthopedic, muscle tissue, skin tissue, nerve and spinal cord, bioimaging, and drug or gene delivery based on citrate-based polymers, have been extensively studied, and many of them have good clinical application potential. In this review, we summarize recent progress in the multifunctional design and biomedical applications of citrate-based polymers. We also discuss the further development of multifunctional citrate-based polymers with tailored properties to meet the requirements of various biomedical applications.http://www.sciencedirect.com/science/article/pii/S2452199X22002043Bioactive materialsBioactive polymersCitrate-based biomaterialsMultifunctional modificationTissue engineering |
| spellingShingle | Min Wang Peng Xu Bo Lei Engineering multifunctional bioactive citrate-based biomaterials for tissue engineering Bioactive Materials Bioactive materials Bioactive polymers Citrate-based biomaterials Multifunctional modification Tissue engineering |
| title | Engineering multifunctional bioactive citrate-based biomaterials for tissue engineering |
| title_full | Engineering multifunctional bioactive citrate-based biomaterials for tissue engineering |
| title_fullStr | Engineering multifunctional bioactive citrate-based biomaterials for tissue engineering |
| title_full_unstemmed | Engineering multifunctional bioactive citrate-based biomaterials for tissue engineering |
| title_short | Engineering multifunctional bioactive citrate-based biomaterials for tissue engineering |
| title_sort | engineering multifunctional bioactive citrate based biomaterials for tissue engineering |
| topic | Bioactive materials Bioactive polymers Citrate-based biomaterials Multifunctional modification Tissue engineering |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X22002043 |
| work_keys_str_mv | AT minwang engineeringmultifunctionalbioactivecitratebasedbiomaterialsfortissueengineering AT pengxu engineeringmultifunctionalbioactivecitratebasedbiomaterialsfortissueengineering AT bolei engineeringmultifunctionalbioactivecitratebasedbiomaterialsfortissueengineering |