HIV infection is associated with elevated biomarkers of immune activation in Ugandan adults with pneumonia.
<h4>Introduction</h4>Pneumonia is an important cause of morbidity and mortality in persons living with human immunodeficiency virus (HIV) infection. How immune activation differs among HIV-infected and HIV-uninfected adults with pneumonia is unknown.<h4>Methods</h4>The Inflam...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0216680 |
| _version_ | 1811167162788741120 |
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| author | Richard J Wang Julia Moore Daniela Moisi Emily G Chang Patrick Byanyima Sylvia Kaswabuli Emmanuel Musisi Ingvar Sanyu Abdulwahab Sessolo Rejani Lalitha William Worodria J Lucian Davis Kristina Crothers Jue Lin Michael M Lederman Peter W Hunt Laurence Huang |
| author_facet | Richard J Wang Julia Moore Daniela Moisi Emily G Chang Patrick Byanyima Sylvia Kaswabuli Emmanuel Musisi Ingvar Sanyu Abdulwahab Sessolo Rejani Lalitha William Worodria J Lucian Davis Kristina Crothers Jue Lin Michael M Lederman Peter W Hunt Laurence Huang |
| author_sort | Richard J Wang |
| collection | DOAJ |
| description | <h4>Introduction</h4>Pneumonia is an important cause of morbidity and mortality in persons living with human immunodeficiency virus (HIV) infection. How immune activation differs among HIV-infected and HIV-uninfected adults with pneumonia is unknown.<h4>Methods</h4>The Inflammation, Aging, Microbes, and Obstructive Lung Disease (I AM OLD) Cohort is a prospective cohort of adults with pneumonia in Uganda. In this cross-sectional analysis, plasma was collected at pneumonia presentation to measure the following 12 biomarkers: interleukin 6 (IL-6), soluble tumor necrosis factor receptors 1 and 2 (sTNFR-1 and sTNFR-2), high sensitivity C-reactive protein (hsCRP), fibrinogen, D-dimer, soluble CD27 (sCD27), interferon gamma-inducible protein 10 (IP-10), soluble CD14 (sCD14), soluble CD163 (sCD163), hyaluronan, and intestinal fatty acid binding protein. We asked whether biomarker levels differed between HIV-infected and HIV-uninfected participants, and whether higher levels of these biomarkers were associated with mortality.<h4>Results</h4>One hundred seventy-three participants were enrolled. Fifty-three percent were HIV-infected. Eight plasma biomarkers-sTNFR-1, sTNFR-2, hsCRP, D-dimer, sCD27, IP-10, sCD14, and hyaluronan-were higher among participants with HIV infection, after adjustment for pneumonia severity. Higher levels of 8 biomarkers-IL-6, sTNFR-1, sTNFR-2, hsCRP, IP-10, sCD14, sCD163, and hyaluronan-were associated with increased 2-month mortality.<h4>Conclusions</h4>As in other clinical contexts, HIV infection is associated with a greater degree of immune activation among Ugandan adults with pneumonia. Some of these are also associated with short-term mortality. Further study is needed to explore whether these biomarkers might predict poor long-term outcomes-such as the development of obstructive lung disease-in patients with HIV who have recovered from pneumonia. |
| first_indexed | 2024-04-10T16:04:32Z |
| format | Article |
| id | doaj.art-26f37f10fcd942b2b7a28967f2c761e7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T16:04:32Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-26f37f10fcd942b2b7a28967f2c761e72023-02-10T05:31:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01145e021668010.1371/journal.pone.0216680HIV infection is associated with elevated biomarkers of immune activation in Ugandan adults with pneumonia.Richard J WangJulia MooreDaniela MoisiEmily G ChangPatrick ByanyimaSylvia KaswabuliEmmanuel MusisiIngvar SanyuAbdulwahab SessoloRejani LalithaWilliam WorodriaJ Lucian DavisKristina CrothersJue LinMichael M LedermanPeter W HuntLaurence Huang<h4>Introduction</h4>Pneumonia is an important cause of morbidity and mortality in persons living with human immunodeficiency virus (HIV) infection. How immune activation differs among HIV-infected and HIV-uninfected adults with pneumonia is unknown.<h4>Methods</h4>The Inflammation, Aging, Microbes, and Obstructive Lung Disease (I AM OLD) Cohort is a prospective cohort of adults with pneumonia in Uganda. In this cross-sectional analysis, plasma was collected at pneumonia presentation to measure the following 12 biomarkers: interleukin 6 (IL-6), soluble tumor necrosis factor receptors 1 and 2 (sTNFR-1 and sTNFR-2), high sensitivity C-reactive protein (hsCRP), fibrinogen, D-dimer, soluble CD27 (sCD27), interferon gamma-inducible protein 10 (IP-10), soluble CD14 (sCD14), soluble CD163 (sCD163), hyaluronan, and intestinal fatty acid binding protein. We asked whether biomarker levels differed between HIV-infected and HIV-uninfected participants, and whether higher levels of these biomarkers were associated with mortality.<h4>Results</h4>One hundred seventy-three participants were enrolled. Fifty-three percent were HIV-infected. Eight plasma biomarkers-sTNFR-1, sTNFR-2, hsCRP, D-dimer, sCD27, IP-10, sCD14, and hyaluronan-were higher among participants with HIV infection, after adjustment for pneumonia severity. Higher levels of 8 biomarkers-IL-6, sTNFR-1, sTNFR-2, hsCRP, IP-10, sCD14, sCD163, and hyaluronan-were associated with increased 2-month mortality.<h4>Conclusions</h4>As in other clinical contexts, HIV infection is associated with a greater degree of immune activation among Ugandan adults with pneumonia. Some of these are also associated with short-term mortality. Further study is needed to explore whether these biomarkers might predict poor long-term outcomes-such as the development of obstructive lung disease-in patients with HIV who have recovered from pneumonia.https://doi.org/10.1371/journal.pone.0216680 |
| spellingShingle | Richard J Wang Julia Moore Daniela Moisi Emily G Chang Patrick Byanyima Sylvia Kaswabuli Emmanuel Musisi Ingvar Sanyu Abdulwahab Sessolo Rejani Lalitha William Worodria J Lucian Davis Kristina Crothers Jue Lin Michael M Lederman Peter W Hunt Laurence Huang HIV infection is associated with elevated biomarkers of immune activation in Ugandan adults with pneumonia. PLoS ONE |
| title | HIV infection is associated with elevated biomarkers of immune activation in Ugandan adults with pneumonia. |
| title_full | HIV infection is associated with elevated biomarkers of immune activation in Ugandan adults with pneumonia. |
| title_fullStr | HIV infection is associated with elevated biomarkers of immune activation in Ugandan adults with pneumonia. |
| title_full_unstemmed | HIV infection is associated with elevated biomarkers of immune activation in Ugandan adults with pneumonia. |
| title_short | HIV infection is associated with elevated biomarkers of immune activation in Ugandan adults with pneumonia. |
| title_sort | hiv infection is associated with elevated biomarkers of immune activation in ugandan adults with pneumonia |
| url | https://doi.org/10.1371/journal.pone.0216680 |
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