Contribution of HCN1 variant to sinus bradycardia: A case report

Contribution of HCN1 variant to sinus bradycardia: A case report

Abstract Background Missense mutations in the hyperpolarization‐activated cyclic nucleotide‐modulated (HCN) channel 4 (HCN4) are one of the genetic causes of cardiac sinus bradycardia. Objective To investigate possible HCN4 channel mutation in a young patient with profound sinus bradycardia. Methods...

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Bibliographic Details
Main Authors: Hangang Yu, Bryan Gall, Mackenzie Newman, Quincy Hathaway, Kathleen Brundage, Amanda Ammer, Peter Mathers, David Siderovski, Robert W. Hull
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:Journal of Arrhythmia
Subjects:
HCN1
HCN4
hyperpolarization‐activated ion channel
missense mutation
sinus bradycardia
whole‐exome sequencing
Online Access:https://doi.org/10.1002/joa3.12598

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