The First Chemically-Synthesised, Highly Immunogenic Anti-SARS-CoV-2 Peptides in DNA Genotyped Aotus Monkeys for Human Use

The First Chemically-Synthesised, Highly Immunogenic Anti-SARS-CoV-2 Peptides in DNA Genotyped Aotus Monkeys for Human Use

Thirty-five peptides selected from functionally-relevant SARS-CoV-2 spike (S), membrane (M), and envelope (E) proteins were suitably modified for immunising MHC class II (MHCII) DNA-genotyped Aotus monkeys and matched with HLA-DRβ1* molecules for use in humans. This was aimed at producing the first...

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Bibliographic Details
Main Authors: Manuel E. Patarroyo, Manuel A. Patarroyo, Martha P. Alba, Laura Pabon, María T. Rugeles, Wbeimar Aguilar-Jimenez, Lizdany Florez, Adriana Bermudez, Ashok K. Rout, Christian Griesinger, Carlos F. Suarez, Jorge Aza-Conde, César Reyes, Catalina Avendaño, Jhoan Samacá, Anny Camargo, Yolanda Silva, Martha Forero, Edgardo Gonzalez
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
neutralising antibody
MHCII-peptide-TCR complex
modified synthetic peptide
HLA-DRβ1*/Aona-DRβ
PPIIL-propensity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.724060/full

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