Results of Treatment of Locoregionally Advanced Head and Neck Cancer by Radiotherapy with or without Chemotherapy
Background: Locally advanced tumors in the head and neck region are malignancies extended from their primary location with no distant metastasis. The main aim of this research was to assess whether the addition of chemotherapy to radiotherapy was able to increase the locoregional control of advanced...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2013-01-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/661 |
| _version_ | 1797760268669812736 |
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| author | Mahnaz Roayaei Abbas Gookizadeh Ali Mehrabi Kooshki Dordaneh Ebrahimi Hoda Mahdavi |
| author_facet | Mahnaz Roayaei Abbas Gookizadeh Ali Mehrabi Kooshki Dordaneh Ebrahimi Hoda Mahdavi |
| author_sort | Mahnaz Roayaei |
| collection | DOAJ |
| description | Background: Locally advanced tumors in the head and neck region are malignancies extended from their primary location with no distant metastasis. The main aim of this research was to assess whether the addition of chemotherapy to radiotherapy was able to increase the locoregional control of advanced squamous cell carcinoma (SCC) of head and neck in a cancer referral center.
Methods: In this cohort study, 215 patients with locoregionally advanced head and neck carcinoma (stages III or IV) who had received conventional radiotherapy (60-70 Gy in 35 fractions) were evaluated. 92 patients had received chemoradiation and 123 patients had received radiotherapy alone. Demographic data was collected from the patients' records. The two groups were compared for local recurrence at each site.
Findings: Rates of local recurrence in the radiotherapy and chemoradiation groups were not significantly different (P = 0.100). However, in paitients who did not undergo surgery, chemoradiation was superior to radiotherapy. Moreover, gender, site of tumor, and tumor grade were significantly related with disease recurrence (P = 0.019).
Conclusion: Our findings showed that adding chemotherapy to conventional radiotherapy may be able to increase the locoregional control of SCC in patients who do not undergo surgery. These findings help improve currently practiced SCC therapeutic strategies.
Keywords: Head and neck neoplasms, Local neoplasm recurrence, Radiotherapy, Adjuvant chemotherapy |
| first_indexed | 2024-03-12T18:56:09Z |
| format | Article |
| id | doaj.art-26faa0073d5d4589bdf5880c3b3db23c |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T18:56:09Z |
| publishDate | 2013-01-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-26faa0073d5d4589bdf5880c3b3db23c2023-08-02T06:48:42ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2013-01-0130213186218671196Results of Treatment of Locoregionally Advanced Head and Neck Cancer by Radiotherapy with or without ChemotherapyMahnaz Roayaei0Abbas Gookizadeh1Ali Mehrabi Kooshki2Dordaneh Ebrahimi3Hoda Mahdavi4Assistant Professor, Department of Radiotherapy, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Radiotherapy, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Epidemiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranRadiotherapist, Mashhad University of Medical Sciences, Mashhad, IranResident, Department of Radiotherapy, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, IranBackground: Locally advanced tumors in the head and neck region are malignancies extended from their primary location with no distant metastasis. The main aim of this research was to assess whether the addition of chemotherapy to radiotherapy was able to increase the locoregional control of advanced squamous cell carcinoma (SCC) of head and neck in a cancer referral center. Methods: In this cohort study, 215 patients with locoregionally advanced head and neck carcinoma (stages III or IV) who had received conventional radiotherapy (60-70 Gy in 35 fractions) were evaluated. 92 patients had received chemoradiation and 123 patients had received radiotherapy alone. Demographic data was collected from the patients' records. The two groups were compared for local recurrence at each site. Findings: Rates of local recurrence in the radiotherapy and chemoradiation groups were not significantly different (P = 0.100). However, in paitients who did not undergo surgery, chemoradiation was superior to radiotherapy. Moreover, gender, site of tumor, and tumor grade were significantly related with disease recurrence (P = 0.019). Conclusion: Our findings showed that adding chemotherapy to conventional radiotherapy may be able to increase the locoregional control of SCC in patients who do not undergo surgery. These findings help improve currently practiced SCC therapeutic strategies. Keywords: Head and neck neoplasms, Local neoplasm recurrence, Radiotherapy, Adjuvant chemotherapyhttp://jims.mui.ac.ir/index.php/jims/article/view/661 |
| spellingShingle | Mahnaz Roayaei Abbas Gookizadeh Ali Mehrabi Kooshki Dordaneh Ebrahimi Hoda Mahdavi Results of Treatment of Locoregionally Advanced Head and Neck Cancer by Radiotherapy with or without Chemotherapy مجله دانشکده پزشکی اصفهان |
| title | Results of Treatment of Locoregionally Advanced Head and Neck Cancer by Radiotherapy with or without Chemotherapy |
| title_full | Results of Treatment of Locoregionally Advanced Head and Neck Cancer by Radiotherapy with or without Chemotherapy |
| title_fullStr | Results of Treatment of Locoregionally Advanced Head and Neck Cancer by Radiotherapy with or without Chemotherapy |
| title_full_unstemmed | Results of Treatment of Locoregionally Advanced Head and Neck Cancer by Radiotherapy with or without Chemotherapy |
| title_short | Results of Treatment of Locoregionally Advanced Head and Neck Cancer by Radiotherapy with or without Chemotherapy |
| title_sort | results of treatment of locoregionally advanced head and neck cancer by radiotherapy with or without chemotherapy |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/661 |
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