Epidemiological, clinical, and household transmission characteristics of children and adolescents infected with SARS-CoV-2 Omicron variant in Shanghai, China: a retrospective, multicenter observational study
Objectives: To describe the epidemiological, clinical, and household transmission characteristics of pediatric COVID-19 cases in Shanghai, China. Methods: Pediatric patients with COVID-19 hospitalized in Shanghai from March-May 2022 were enrolled in this retrospective, multicenter cohort study. The...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-04-01
|
| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971223000310 |
| _version_ | 1827987838216437760 |
|---|---|
| author | Yazun Liu Lan Xu Xiang Piao Han Li Li Shi Yue Huang Huan Zhou Yan Yang Xiao Liu Mingyun Wu Yuanyuan He Yong Yin Libo Wang Jian Yu Wenhao Zhou Junhua Zheng Victor W. Zhong Zheng Xue Liwei Zhong |
| author_facet | Yazun Liu Lan Xu Xiang Piao Han Li Li Shi Yue Huang Huan Zhou Yan Yang Xiao Liu Mingyun Wu Yuanyuan He Yong Yin Libo Wang Jian Yu Wenhao Zhou Junhua Zheng Victor W. Zhong Zheng Xue Liwei Zhong |
| author_sort | Yazun Liu |
| collection | DOAJ |
| description | Objectives: To describe the epidemiological, clinical, and household transmission characteristics of pediatric COVID-19 cases in Shanghai, China. Methods: Pediatric patients with COVID-19 hospitalized in Shanghai from March-May 2022 were enrolled in this retrospective, multicenter cohort study. The symptoms and the risk factors associated with disease severity were analyzed. Results: In total, 2620 cases (age range, 24 days-17 years) were enrolled in this study. Of these, 1011 (38.6%) were asymptomatic, whereas 1415 (54.0%), 190 (7.3%), and 4 (0.2%) patients developed mild, moderate, and severe illnesses, respectively. Household infection rate was negatively correlated with household vaccination coverage. Children aged 0-3 years, those who are unvaccinated, those with underlying diseases, and overweight/obese children had a higher risk of developing moderate to severe disease than children aged 12-17 years, those who were vaccinated, those without any underlying disease, and those with normal weight, respectively (all P <0.05). A prolonged duration of viral shedding was associated with disease severity, presence of underlying diseases, vaccination status, and younger age (all P <0.05). Conclusion: Children aged younger than 3 years who were not eligible for vaccination had a high risk of developing moderate to severe COVID-19 with a prolonged duration of viral shedding. Vaccination could protect children from COVID-19 at the household level. |
| first_indexed | 2024-04-09T23:54:21Z |
| format | Article |
| id | doaj.art-26fcabf08a294de280e19073334cacb5 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-09T23:54:21Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-26fcabf08a294de280e19073334cacb52023-03-17T04:32:45ZengElsevierInternational Journal of Infectious Diseases1201-97122023-04-0112919Epidemiological, clinical, and household transmission characteristics of children and adolescents infected with SARS-CoV-2 Omicron variant in Shanghai, China: a retrospective, multicenter observational studyYazun Liu0Lan Xu1Xiang Piao2Han Li3Li Shi4Yue Huang5Huan Zhou6Yan Yang7Xiao Liu8Mingyun Wu9Yuanyuan He10Yong Yin11Libo Wang12Jian Yu13Wenhao Zhou14Junhua Zheng15Victor W. Zhong16Zheng Xue17Liwei Zhong18Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaLonghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaChildren's Hospital of Fudan University, Shanghai, ChinaDepartment of Respiratory, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Corresponding authors.Children's Hospital of Fudan University, Shanghai, China; Corresponding authors.Children's Hospital of Fudan University, Shanghai, China; Corresponding authors.Children's Hospital of Fudan University, Shanghai, China; Corresponding authors.Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Corresponding authors.Department of Epidemiology and Biostatistics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Corresponding authors.Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Corresponding authors.Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Corresponding authors.Objectives: To describe the epidemiological, clinical, and household transmission characteristics of pediatric COVID-19 cases in Shanghai, China. Methods: Pediatric patients with COVID-19 hospitalized in Shanghai from March-May 2022 were enrolled in this retrospective, multicenter cohort study. The symptoms and the risk factors associated with disease severity were analyzed. Results: In total, 2620 cases (age range, 24 days-17 years) were enrolled in this study. Of these, 1011 (38.6%) were asymptomatic, whereas 1415 (54.0%), 190 (7.3%), and 4 (0.2%) patients developed mild, moderate, and severe illnesses, respectively. Household infection rate was negatively correlated with household vaccination coverage. Children aged 0-3 years, those who are unvaccinated, those with underlying diseases, and overweight/obese children had a higher risk of developing moderate to severe disease than children aged 12-17 years, those who were vaccinated, those without any underlying disease, and those with normal weight, respectively (all P <0.05). A prolonged duration of viral shedding was associated with disease severity, presence of underlying diseases, vaccination status, and younger age (all P <0.05). Conclusion: Children aged younger than 3 years who were not eligible for vaccination had a high risk of developing moderate to severe COVID-19 with a prolonged duration of viral shedding. Vaccination could protect children from COVID-19 at the household level.http://www.sciencedirect.com/science/article/pii/S1201971223000310OmicronSARS-CoV-2EpidemiologyPediatricsHousehold transmission |
| spellingShingle | Yazun Liu Lan Xu Xiang Piao Han Li Li Shi Yue Huang Huan Zhou Yan Yang Xiao Liu Mingyun Wu Yuanyuan He Yong Yin Libo Wang Jian Yu Wenhao Zhou Junhua Zheng Victor W. Zhong Zheng Xue Liwei Zhong Epidemiological, clinical, and household transmission characteristics of children and adolescents infected with SARS-CoV-2 Omicron variant in Shanghai, China: a retrospective, multicenter observational study International Journal of Infectious Diseases Omicron SARS-CoV-2 Epidemiology Pediatrics Household transmission |
| title | Epidemiological, clinical, and household transmission characteristics of children and adolescents infected with SARS-CoV-2 Omicron variant in Shanghai, China: a retrospective, multicenter observational study |
| title_full | Epidemiological, clinical, and household transmission characteristics of children and adolescents infected with SARS-CoV-2 Omicron variant in Shanghai, China: a retrospective, multicenter observational study |
| title_fullStr | Epidemiological, clinical, and household transmission characteristics of children and adolescents infected with SARS-CoV-2 Omicron variant in Shanghai, China: a retrospective, multicenter observational study |
| title_full_unstemmed | Epidemiological, clinical, and household transmission characteristics of children and adolescents infected with SARS-CoV-2 Omicron variant in Shanghai, China: a retrospective, multicenter observational study |
| title_short | Epidemiological, clinical, and household transmission characteristics of children and adolescents infected with SARS-CoV-2 Omicron variant in Shanghai, China: a retrospective, multicenter observational study |
| title_sort | epidemiological clinical and household transmission characteristics of children and adolescents infected with sars cov 2 omicron variant in shanghai china a retrospective multicenter observational study |
| topic | Omicron SARS-CoV-2 Epidemiology Pediatrics Household transmission |
| url | http://www.sciencedirect.com/science/article/pii/S1201971223000310 |
| work_keys_str_mv | AT yazunliu epidemiologicalclinicalandhouseholdtransmissioncharacteristicsofchildrenandadolescentsinfectedwithsarscov2omicronvariantinshanghaichinaaretrospectivemulticenterobservationalstudy AT lanxu epidemiologicalclinicalandhouseholdtransmissioncharacteristicsofchildrenandadolescentsinfectedwithsarscov2omicronvariantinshanghaichinaaretrospectivemulticenterobservationalstudy AT xiangpiao epidemiologicalclinicalandhouseholdtransmissioncharacteristicsofchildrenandadolescentsinfectedwithsarscov2omicronvariantinshanghaichinaaretrospectivemulticenterobservationalstudy AT hanli epidemiologicalclinicalandhouseholdtransmissioncharacteristicsofchildrenandadolescentsinfectedwithsarscov2omicronvariantinshanghaichinaaretrospectivemulticenterobservationalstudy AT lishi epidemiologicalclinicalandhouseholdtransmissioncharacteristicsofchildrenandadolescentsinfectedwithsarscov2omicronvariantinshanghaichinaaretrospectivemulticenterobservationalstudy AT yuehuang epidemiologicalclinicalandhouseholdtransmissioncharacteristicsofchildrenandadolescentsinfectedwithsarscov2omicronvariantinshanghaichinaaretrospectivemulticenterobservationalstudy AT huanzhou epidemiologicalclinicalandhouseholdtransmissioncharacteristicsofchildrenandadolescentsinfectedwithsarscov2omicronvariantinshanghaichinaaretrospectivemulticenterobservationalstudy AT yanyang epidemiologicalclinicalandhouseholdtransmissioncharacteristicsofchildrenandadolescentsinfectedwithsarscov2omicronvariantinshanghaichinaaretrospectivemulticenterobservationalstudy AT xiaoliu epidemiologicalclinicalandhouseholdtransmissioncharacteristicsofchildrenandadolescentsinfectedwithsarscov2omicronvariantinshanghaichinaaretrospectivemulticenterobservationalstudy AT mingyunwu epidemiologicalclinicalandhouseholdtransmissioncharacteristicsofchildrenandadolescentsinfectedwithsarscov2omicronvariantinshanghaichinaaretrospectivemulticenterobservationalstudy AT yuanyuanhe epidemiologicalclinicalandhouseholdtransmissioncharacteristicsofchildrenandadolescentsinfectedwithsarscov2omicronvariantinshanghaichinaaretrospectivemulticenterobservationalstudy AT yongyin epidemiologicalclinicalandhouseholdtransmissioncharacteristicsofchildrenandadolescentsinfectedwithsarscov2omicronvariantinshanghaichinaaretrospectivemulticenterobservationalstudy AT libowang epidemiologicalclinicalandhouseholdtransmissioncharacteristicsofchildrenandadolescentsinfectedwithsarscov2omicronvariantinshanghaichinaaretrospectivemulticenterobservationalstudy AT jianyu epidemiologicalclinicalandhouseholdtransmissioncharacteristicsofchildrenandadolescentsinfectedwithsarscov2omicronvariantinshanghaichinaaretrospectivemulticenterobservationalstudy AT wenhaozhou epidemiologicalclinicalandhouseholdtransmissioncharacteristicsofchildrenandadolescentsinfectedwithsarscov2omicronvariantinshanghaichinaaretrospectivemulticenterobservationalstudy AT junhuazheng epidemiologicalclinicalandhouseholdtransmissioncharacteristicsofchildrenandadolescentsinfectedwithsarscov2omicronvariantinshanghaichinaaretrospectivemulticenterobservationalstudy AT victorwzhong epidemiologicalclinicalandhouseholdtransmissioncharacteristicsofchildrenandadolescentsinfectedwithsarscov2omicronvariantinshanghaichinaaretrospectivemulticenterobservationalstudy AT zhengxue epidemiologicalclinicalandhouseholdtransmissioncharacteristicsofchildrenandadolescentsinfectedwithsarscov2omicronvariantinshanghaichinaaretrospectivemulticenterobservationalstudy AT liweizhong epidemiologicalclinicalandhouseholdtransmissioncharacteristicsofchildrenandadolescentsinfectedwithsarscov2omicronvariantinshanghaichinaaretrospectivemulticenterobservationalstudy |