The Effect of Three Forms of Local Corticosteroids on Sinonasal Polyposis
Introduction: Since sinonasal polyposis (SNP) has a high recurrence rate after surgery, various studies have investigated the effect of corticosteroid medications to prevent disease recurrence. The present study was designed to compare the effect of three forms of local corticosteroids on preventing...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mashhad University of Medical Sciences
2024-01-01
|
| Series: | Iranian Journal of Otorhinolaryngology |
| Subjects: | |
| Online Access: | https://ijorl.mums.ac.ir/article_23662_041faafca297fb967ce771aa92efbe41.pdf |
| _version_ | 1797205556995293184 |
|---|---|
| author | Matin Ghazizadeh Ali Goljanian Tabrizi Najmeh Rajabi |
| author_facet | Matin Ghazizadeh Ali Goljanian Tabrizi Najmeh Rajabi |
| author_sort | Matin Ghazizadeh |
| collection | DOAJ |
| description | Introduction: Since sinonasal polyposis (SNP) has a high recurrence rate after surgery, various studies have investigated the effect of corticosteroid medications to prevent disease recurrence. The present study was designed to compare the effect of three forms of local corticosteroids on preventing SNP recurrence post-operatively.Materials and Methods: This double-blind, randomized clinical trial study was conducted on 108 patients with SNP who underwent functional endoscopic sinus surgery (FESS). Permuted Block Randomization randomly assigned patients into three groups of 36 people: budesonide spray, betamethasone drop, and budesonide nebulizing suspension groups. One and six months after surgery, the patients were evaluated for recurrence of SNP by nasal endoscopy. SNOT 22 questionnaire was used to assess patients’ subjective improvement rate pre- and post-operatively.Results: According to the scores obtained in the Modified Lund-Kennedy Scoring, budesonide nebulizing suspension showed better effects on preventing the recurrence of sino-nasal polyps after FESS compared with betamethasone nasal drops. The score was significantly lower in the budesonide nebulizing suspension group compared to the betamethasone drop group (P=0.043). There was no statistically significant difference in the scores between the budesonide nebulizing suspension group and the betamethasone spray group (P=0.178). Also, we observed significant improvement in facial fullness in patients who received Budesonide nebulizing suspension.Conclusions: Budesonide nebulizing suspension, compared to betamethasone nasal drops, showed better effects on preventing the recurrence of SNP after FESS. |
| first_indexed | 2024-04-24T08:53:00Z |
| format | Article |
| id | doaj.art-26fd1aba5661408f90bd675118cd40dd |
| institution | Directory Open Access Journal |
| issn | 2251-7251 2251-726X |
| language | English |
| last_indexed | 2024-04-24T08:53:00Z |
| publishDate | 2024-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Otorhinolaryngology |
| spelling | doaj.art-26fd1aba5661408f90bd675118cd40dd2024-04-16T09:04:01ZengMashhad University of Medical SciencesIranian Journal of Otorhinolaryngology2251-72512251-726X2024-01-0136134935310.22038/ijorl.2023.75247.352423662The Effect of Three Forms of Local Corticosteroids on Sinonasal PolyposisMatin Ghazizadeh0Ali Goljanian Tabrizi1Najmeh Rajabi2Department of Otorhinolaryngology, Head and Neck Surgery, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Otorhinolaryngology, Head and Neck Surgery, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Otorhinolaryngology, Head and Neck Surgery, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Introduction: Since sinonasal polyposis (SNP) has a high recurrence rate after surgery, various studies have investigated the effect of corticosteroid medications to prevent disease recurrence. The present study was designed to compare the effect of three forms of local corticosteroids on preventing SNP recurrence post-operatively.Materials and Methods: This double-blind, randomized clinical trial study was conducted on 108 patients with SNP who underwent functional endoscopic sinus surgery (FESS). Permuted Block Randomization randomly assigned patients into three groups of 36 people: budesonide spray, betamethasone drop, and budesonide nebulizing suspension groups. One and six months after surgery, the patients were evaluated for recurrence of SNP by nasal endoscopy. SNOT 22 questionnaire was used to assess patients’ subjective improvement rate pre- and post-operatively.Results: According to the scores obtained in the Modified Lund-Kennedy Scoring, budesonide nebulizing suspension showed better effects on preventing the recurrence of sino-nasal polyps after FESS compared with betamethasone nasal drops. The score was significantly lower in the budesonide nebulizing suspension group compared to the betamethasone drop group (P=0.043). There was no statistically significant difference in the scores between the budesonide nebulizing suspension group and the betamethasone spray group (P=0.178). Also, we observed significant improvement in facial fullness in patients who received Budesonide nebulizing suspension.Conclusions: Budesonide nebulizing suspension, compared to betamethasone nasal drops, showed better effects on preventing the recurrence of SNP after FESS.https://ijorl.mums.ac.ir/article_23662_041faafca297fb967ce771aa92efbe41.pdfcorticosteroidsparanasal sinusesrecurrence |
| spellingShingle | Matin Ghazizadeh Ali Goljanian Tabrizi Najmeh Rajabi The Effect of Three Forms of Local Corticosteroids on Sinonasal Polyposis Iranian Journal of Otorhinolaryngology corticosteroids paranasal sinuses recurrence |
| title | The Effect of Three Forms of Local Corticosteroids on Sinonasal Polyposis |
| title_full | The Effect of Three Forms of Local Corticosteroids on Sinonasal Polyposis |
| title_fullStr | The Effect of Three Forms of Local Corticosteroids on Sinonasal Polyposis |
| title_full_unstemmed | The Effect of Three Forms of Local Corticosteroids on Sinonasal Polyposis |
| title_short | The Effect of Three Forms of Local Corticosteroids on Sinonasal Polyposis |
| title_sort | effect of three forms of local corticosteroids on sinonasal polyposis |
| topic | corticosteroids paranasal sinuses recurrence |
| url | https://ijorl.mums.ac.ir/article_23662_041faafca297fb967ce771aa92efbe41.pdf |
| work_keys_str_mv | AT matinghazizadeh theeffectofthreeformsoflocalcorticosteroidsonsinonasalpolyposis AT aligoljaniantabrizi theeffectofthreeformsoflocalcorticosteroidsonsinonasalpolyposis AT najmehrajabi theeffectofthreeformsoflocalcorticosteroidsonsinonasalpolyposis AT matinghazizadeh effectofthreeformsoflocalcorticosteroidsonsinonasalpolyposis AT aligoljaniantabrizi effectofthreeformsoflocalcorticosteroidsonsinonasalpolyposis AT najmehrajabi effectofthreeformsoflocalcorticosteroidsonsinonasalpolyposis |