Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery
Rong Liu,1,2,* Yusi Lai,1,* Bin He,1 Yuan Li,1 Gang Wang,1 Shuang Chang,1 Zhongwei Gu1 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China; 2Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China*These authors contributed equally to th...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2012-10-01
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| Series: | International Journal of Nanomedicine |
| Online Access: | http://www.dovepress.com/supramolecular-nanoparticles-generated-by-the-self-assembly-of-polyrot-a11195 |
| _version_ | 1818936514014347264 |
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| author | Liu R Lai YS He B Li Y Wang G Chang S Gu Z |
| author_facet | Liu R Lai YS He B Li Y Wang G Chang S Gu Z |
| author_sort | Liu R |
| collection | DOAJ |
| description | Rong Liu,1,2,* Yusi Lai,1,* Bin He,1 Yuan Li,1 Gang Wang,1 Shuang Chang,1 Zhongwei Gu1 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China; 2Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China*These authors contributed equally to this paperAbstract: A new approach of fabricating supramolecular nanoparticles generated by self-assembly polyrotaxanes for antitumor drug delivery has been reported. Cinnamic-acid-modified poly(ethylene glycol) chains were threaded in a-cyclodextrins to form polyrotaxanes. The polyrotaxanes self-assembled supramolecular nanoparticles. The morphology of the nanoparticles was changed from nanovesicle to micelle after the antitumor drug, doxorubicin, was loaded. The release profile of the drug-loaded nanoparticles was investigated, and it was found that the sustaining release time could last for 32 hours. The drug-loaded nanoparticles were co-cultured with mouse 4T1 breast cancer cells with a drug concentration of 10 µg/mL; the cell survival rate was 3.3% after a 72-hour incubation. In an in vivo study of breast cancer in a mouse model, the drug-loaded nanoparticles were injected in the tail veins of mice with a dose of 5 mg/kg body weight. The tumor inhibition rate of drug-loaded nanoparticles was 53%, which was better than that of doxorubicin hydrochloride. The cardiac toxicity of doxorubicin was decreased greatly after the encapsulation into supramolecular polyrotaxane nanoparticles.Keywords: polyrotaxane, self-assembly, nanoparticle, doxorubicin, supermolecular |
| first_indexed | 2024-12-20T05:37:16Z |
| format | Article |
| id | doaj.art-26fdd870ba9d4eafad73950e86722b7f |
| institution | Directory Open Access Journal |
| issn | 1176-9114 1178-2013 |
| language | English |
| last_indexed | 2024-12-20T05:37:16Z |
| publishDate | 2012-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-26fdd870ba9d4eafad73950e86722b7f2022-12-21T19:51:35ZengDove Medical PressInternational Journal of Nanomedicine1176-91141178-20132012-10-012012default52495258Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug deliveryLiu RLai YSHe BLi YWang GChang SGu ZRong Liu,1,2,* Yusi Lai,1,* Bin He,1 Yuan Li,1 Gang Wang,1 Shuang Chang,1 Zhongwei Gu1 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China; 2Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China*These authors contributed equally to this paperAbstract: A new approach of fabricating supramolecular nanoparticles generated by self-assembly polyrotaxanes for antitumor drug delivery has been reported. Cinnamic-acid-modified poly(ethylene glycol) chains were threaded in a-cyclodextrins to form polyrotaxanes. The polyrotaxanes self-assembled supramolecular nanoparticles. The morphology of the nanoparticles was changed from nanovesicle to micelle after the antitumor drug, doxorubicin, was loaded. The release profile of the drug-loaded nanoparticles was investigated, and it was found that the sustaining release time could last for 32 hours. The drug-loaded nanoparticles were co-cultured with mouse 4T1 breast cancer cells with a drug concentration of 10 µg/mL; the cell survival rate was 3.3% after a 72-hour incubation. In an in vivo study of breast cancer in a mouse model, the drug-loaded nanoparticles were injected in the tail veins of mice with a dose of 5 mg/kg body weight. The tumor inhibition rate of drug-loaded nanoparticles was 53%, which was better than that of doxorubicin hydrochloride. The cardiac toxicity of doxorubicin was decreased greatly after the encapsulation into supramolecular polyrotaxane nanoparticles.Keywords: polyrotaxane, self-assembly, nanoparticle, doxorubicin, supermolecularhttp://www.dovepress.com/supramolecular-nanoparticles-generated-by-the-self-assembly-of-polyrot-a11195 |
| spellingShingle | Liu R Lai YS He B Li Y Wang G Chang S Gu Z Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery International Journal of Nanomedicine |
| title | Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery |
| title_full | Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery |
| title_fullStr | Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery |
| title_full_unstemmed | Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery |
| title_short | Supramolecular nanoparticles generated by the self-assembly of polyrotaxanes for antitumor drug delivery |
| title_sort | supramolecular nanoparticles generated by the self assembly of polyrotaxanes for antitumor drug delivery |
| url | http://www.dovepress.com/supramolecular-nanoparticles-generated-by-the-self-assembly-of-polyrot-a11195 |
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