p53/NF-kB Balance in SARS-CoV-2 Infection: From OMICs, Genomics and Pharmacogenomics Insights to Tailored Therapeutic Perspectives (COVIDomics)

p53/NF-kB Balance in SARS-CoV-2 Infection: From OMICs, Genomics and Pharmacogenomics Insights to Tailored Therapeutic Perspectives (COVIDomics)

SARS-CoV-2 infection affects different organs and tissues, including the upper and lower airways, the lung, the gut, the olfactory system and the eye, which may represent one of the gates to the central nervous system. Key transcriptional factors, such as p53 and NF-kB and their reciprocal balance,...

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Bibliographic Details
Main Authors: Daniela Milani, Lorenzo Caruso, Enrico Zauli, Adi Mohammed Al Owaifeer, Paola Secchiero, Giorgio Zauli, Donato Gemmati, Veronica Tisato
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
SARS-CoV-2
p53
NF-kB
ACE2
cytokine-storm
omics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.871583/full

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