Effect of Traditional Korean Medicine Oncotherapy on the Survival, Quality of Life, and Telomere Length: A Prospective Cohort Study
A 4-year prospective cohort study on patients with lung, gastric, hepatic, colorectal, breast, uterine, and ovarian cancer was conducted at the East-West Cancer Center (EWCC) of Daejeon Korean Medicine Hospital in Daejeon, Korea. We divided patients into 2 groups based on how long they had been rece...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-08-01
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| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/15347354231154267 |
| _version_ | 1827856624054697984 |
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| author | Su-Jung Ha PhD Eunbin Kwag MS Soodam Kim MS Ji-Hye Park PhD So-Jung Park PhD Hwa-Seung Yoo PhD |
| author_facet | Su-Jung Ha PhD Eunbin Kwag MS Soodam Kim MS Ji-Hye Park PhD So-Jung Park PhD Hwa-Seung Yoo PhD |
| author_sort | Su-Jung Ha PhD |
| collection | DOAJ |
| description | A 4-year prospective cohort study on patients with lung, gastric, hepatic, colorectal, breast, uterine, and ovarian cancer was conducted at the East-West Cancer Center (EWCC) of Daejeon Korean Medicine Hospital in Daejeon, Korea. We divided patients into 2 groups based on how long they had been receiving TKM oncotherapy and compared event-free survival (EFS), telomere length change, and quality of life (QoL). The study collected data on 83 patients from October 2016 to June 2020 and discovered no statistical differences in EFS based on the duration of TKM oncotherapy. In the analysis of changes in QoL outcomes, there were no statistically significant group differences between the groups. After controlling for covariates that could affect telomere length, the long-term TKM oncotherapy group had a higher daily telomere attrition rate. The study of the relationship between telomere length and prognostic factors discovered that patients with advanced N stage at the time of diagnosis and who had previously received radiotherapy had shorter telomere length. When examining associations between SNP genotype and percentile score of telomere length, this study was able to confirm an association between telomere length and rs4387287. This study is significant because it is the first to assess the effects of TKM oncotherapy and investigate telomere length-related factors. To assess the effects of TKM oncotherapy on cancer patients’ survival and QoL, a longer-term observational study with a larger sample size is required. |
| first_indexed | 2024-03-12T12:28:28Z |
| format | Article |
| id | doaj.art-270046f56d2540bc93493bfd3641eb27 |
| institution | Directory Open Access Journal |
| issn | 1552-695X |
| language | English |
| last_indexed | 2024-03-12T12:28:28Z |
| publishDate | 2023-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj.art-270046f56d2540bc93493bfd3641eb272023-08-29T18:24:21ZengSAGE PublishingIntegrative Cancer Therapies1552-695X2023-08-012210.1177/15347354231154267Effect of Traditional Korean Medicine Oncotherapy on the Survival, Quality of Life, and Telomere Length: A Prospective Cohort StudySu-Jung Ha PhD0Eunbin Kwag MS1Soodam Kim MS2Ji-Hye Park PhD3So-Jung Park PhD4Hwa-Seung Yoo PhD5Daejeon University, Daejeon City, Republic of KoreaDaejeon University, Daejeon City, Republic of KoreaMemorial Sloan Kettering Cancer Center, New York, NY, USADaejeon University, Seoul, Republic of KoreaPusan National University Yangsan-si, Gyeongsangnam-do, Republic of KoreaDaejeon University, Seoul, Republic of KoreaA 4-year prospective cohort study on patients with lung, gastric, hepatic, colorectal, breast, uterine, and ovarian cancer was conducted at the East-West Cancer Center (EWCC) of Daejeon Korean Medicine Hospital in Daejeon, Korea. We divided patients into 2 groups based on how long they had been receiving TKM oncotherapy and compared event-free survival (EFS), telomere length change, and quality of life (QoL). The study collected data on 83 patients from October 2016 to June 2020 and discovered no statistical differences in EFS based on the duration of TKM oncotherapy. In the analysis of changes in QoL outcomes, there were no statistically significant group differences between the groups. After controlling for covariates that could affect telomere length, the long-term TKM oncotherapy group had a higher daily telomere attrition rate. The study of the relationship between telomere length and prognostic factors discovered that patients with advanced N stage at the time of diagnosis and who had previously received radiotherapy had shorter telomere length. When examining associations between SNP genotype and percentile score of telomere length, this study was able to confirm an association between telomere length and rs4387287. This study is significant because it is the first to assess the effects of TKM oncotherapy and investigate telomere length-related factors. To assess the effects of TKM oncotherapy on cancer patients’ survival and QoL, a longer-term observational study with a larger sample size is required.https://doi.org/10.1177/15347354231154267 |
| spellingShingle | Su-Jung Ha PhD Eunbin Kwag MS Soodam Kim MS Ji-Hye Park PhD So-Jung Park PhD Hwa-Seung Yoo PhD Effect of Traditional Korean Medicine Oncotherapy on the Survival, Quality of Life, and Telomere Length: A Prospective Cohort Study Integrative Cancer Therapies |
| title | Effect of Traditional Korean Medicine Oncotherapy on the Survival, Quality of Life, and Telomere Length: A Prospective Cohort Study |
| title_full | Effect of Traditional Korean Medicine Oncotherapy on the Survival, Quality of Life, and Telomere Length: A Prospective Cohort Study |
| title_fullStr | Effect of Traditional Korean Medicine Oncotherapy on the Survival, Quality of Life, and Telomere Length: A Prospective Cohort Study |
| title_full_unstemmed | Effect of Traditional Korean Medicine Oncotherapy on the Survival, Quality of Life, and Telomere Length: A Prospective Cohort Study |
| title_short | Effect of Traditional Korean Medicine Oncotherapy on the Survival, Quality of Life, and Telomere Length: A Prospective Cohort Study |
| title_sort | effect of traditional korean medicine oncotherapy on the survival quality of life and telomere length a prospective cohort study |
| url | https://doi.org/10.1177/15347354231154267 |
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