Utilizing induced neural stem cell‐based delivery of a cytokine cocktail to enhance chimeric antigen receptor‐modified T‐cell therapy for brain cancer

Utilizing induced neural stem cell‐based delivery of a cytokine cocktail to enhance chimeric antigen receptor‐modified T‐cell therapy for brain cancer

Abstract Chimeric antigen receptor (CAR)‐modified T‐cell therapy has shown enormous clinical promise against blood cancers, yet efficacy against solid tumors remains a challenge. Here, we investigated the potential of a new combination cell therapy, where tumor‐homing induced neural stem cells (iNSC...

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Bibliographic Details
Main Authors: Alex S. Woodell, Elisa Landoni, Alain Valdivia, Andrew Buckley, Edikan A. Ogunnaike, Gianpietro Dotti, Shawn D. Hingtgen
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:Bioengineering & Translational Medicine
Subjects:
chimeric antigen receptor T cell
CSPG4 antigen
glioblastoma
IL‐15
neural stem cell
RANTES
Online Access:https://doi.org/10.1002/btm2.10538

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