CUX1, A Controversial Player in Tumor Development
CUX1 belongs to the homeodomain transcription factor family and is evolutionarily and functionally conserved from Drosophila to humans. In addition to the involvement in various physiological events including tissue development, cell proliferation, differentiation and migration, and DNA damage respo...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.00738/full |
| _version_ | 1819066580228636672 |
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| author | Ning Liu Qiliang Sun Long Wan Xuan Wang Yu Feng Judong Luo Hailong Wu Hailong Wu Hailong Wu |
| author_facet | Ning Liu Qiliang Sun Long Wan Xuan Wang Yu Feng Judong Luo Hailong Wu Hailong Wu Hailong Wu |
| author_sort | Ning Liu |
| collection | DOAJ |
| description | CUX1 belongs to the homeodomain transcription factor family and is evolutionarily and functionally conserved from Drosophila to humans. In addition to the involvement in various physiological events including tissue development, cell proliferation, differentiation and migration, and DNA damage response, CUX1 has been implicated in tumorigenesis. Interestingly, CUX1 has been recently recognized as a haploinsufficient tumor suppressor, which is paradoxically overexpressed in tumor cells. While loss of heterozygosity and/or mutations of CUX1 have been frequently detected in many types of cancers, genomic amplification, and overexpression of CUX1 have also been reported in cancer tissues and are correlated with higher tumor grade and poor prognosis. Therefore, deciphering the roles of different CUX1 isoforms and in different tumor stages is required to establish a CUX1-based therapeutic strategy for cancer treatment. |
| first_indexed | 2024-12-21T16:04:37Z |
| format | Article |
| id | doaj.art-270442a2209141b0bbcc8206b3b9b363 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T16:04:37Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-270442a2209141b0bbcc8206b3b9b3632022-12-21T18:57:54ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-05-011010.3389/fonc.2020.00738534066CUX1, A Controversial Player in Tumor DevelopmentNing Liu0Qiliang Sun1Long Wan2Xuan Wang3Yu Feng4Judong Luo5Hailong Wu6Hailong Wu7Hailong Wu8Department of Clinical Oncology, Taian City Central Hospital, Tai'an, ChinaDepartment of Respiratory Medicine, Taian City Central Hospital, Tai'an, ChinaDepartment of Clinical Oncology, Taian City Central Hospital, Tai'an, ChinaDepartment of Liver Diseases, Central Laboratory, Institute of Clinical Immunology, ShuGuang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine, Shanghai, ChinaDepartment of General Surgery, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Radiation Oncology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, ChinaShanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, ChinaCollaborative Innovation Center for Biomedicine, Shanghai University of Medicine & Health Sciences, Shanghai, ChinaShanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai, ChinaCUX1 belongs to the homeodomain transcription factor family and is evolutionarily and functionally conserved from Drosophila to humans. In addition to the involvement in various physiological events including tissue development, cell proliferation, differentiation and migration, and DNA damage response, CUX1 has been implicated in tumorigenesis. Interestingly, CUX1 has been recently recognized as a haploinsufficient tumor suppressor, which is paradoxically overexpressed in tumor cells. While loss of heterozygosity and/or mutations of CUX1 have been frequently detected in many types of cancers, genomic amplification, and overexpression of CUX1 have also been reported in cancer tissues and are correlated with higher tumor grade and poor prognosis. Therefore, deciphering the roles of different CUX1 isoforms and in different tumor stages is required to establish a CUX1-based therapeutic strategy for cancer treatment.https://www.frontiersin.org/article/10.3389/fonc.2020.00738/fullCUX1haploinsufficient tumor suppressortumor progressionDNA damageKRAS mutation |
| spellingShingle | Ning Liu Qiliang Sun Long Wan Xuan Wang Yu Feng Judong Luo Hailong Wu Hailong Wu Hailong Wu CUX1, A Controversial Player in Tumor Development Frontiers in Oncology CUX1 haploinsufficient tumor suppressor tumor progression DNA damage KRAS mutation |
| title | CUX1, A Controversial Player in Tumor Development |
| title_full | CUX1, A Controversial Player in Tumor Development |
| title_fullStr | CUX1, A Controversial Player in Tumor Development |
| title_full_unstemmed | CUX1, A Controversial Player in Tumor Development |
| title_short | CUX1, A Controversial Player in Tumor Development |
| title_sort | cux1 a controversial player in tumor development |
| topic | CUX1 haploinsufficient tumor suppressor tumor progression DNA damage KRAS mutation |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.00738/full |
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