Plant lectins: A new antimicrobial frontier
Pathogenic bacteria, viruses, fungi, parasites, and other microbes constantly change to ensure survival. Several pathogens have adopted strict and intricate strategies to fight medical treatments. Many drugs, frequently prescribed to treat these pathogens, are becoming obsolete and ineffective. Beca...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222011246 |
| _version_ | 1811340007589281792 |
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| author | Emadeldin Hassan E. Konozy Makarim El-fadil M. Osman Amina I. Dirar George Ghartey-Kwansah |
| author_facet | Emadeldin Hassan E. Konozy Makarim El-fadil M. Osman Amina I. Dirar George Ghartey-Kwansah |
| author_sort | Emadeldin Hassan E. Konozy |
| collection | DOAJ |
| description | Pathogenic bacteria, viruses, fungi, parasites, and other microbes constantly change to ensure survival. Several pathogens have adopted strict and intricate strategies to fight medical treatments. Many drugs, frequently prescribed to treat these pathogens, are becoming obsolete and ineffective. Because pathogens have gained the capacity to tolerate or resist medications targeted at them, hence the term antimicrobial resistance (AMR), in that regard, many natural compounds have been routinely used as new antimicrobial agents to treat infections. Thus, plant lectins, the carbohydrate-binding proteins, have been targeted as promising drug candidates. This article reviewed more than 150 published papers on plant lectins with promising antibacterial and antifungal properties. We have also demonstrated how some plant lectins could express a synergistic action as adjuvants to boost the efficacy of obsolete or abandoned antimicrobial drugs. Emphasis has also been given to their plausible mechanism of action. The study further reports on the immunomodulatory effect of plant lectins and how they boost the immune system to curb or prevent infection. |
| first_indexed | 2024-04-13T18:34:56Z |
| format | Article |
| id | doaj.art-27049417d4d744e193a06059b53ab921 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-13T18:34:56Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-27049417d4d744e193a06059b53ab9212022-12-22T02:34:55ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-11-01155113735Plant lectins: A new antimicrobial frontierEmadeldin Hassan E. Konozy0Makarim El-fadil M. Osman1Amina I. Dirar2George Ghartey-Kwansah3Department of Biotechnology, Africa City of Technology, Khartoum, Sudan; Correspondence to: Biotechnology Department, Africa City of Technology (ACT), Blue Nile Bridge Ave., 4 A/2 Alamlak, Bahri Central, Khartoum 11111, Sudan.Department of Biotechnology, Africa City of Technology, Khartoum, SudanMedicinal, Aromatic Plants and Traditional Medicine Research Institute (MAPTRI), National Center for Research, Mek Nimr Street, Khartoum, SudanDepartment of Biomedical Sciences, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, GhanaPathogenic bacteria, viruses, fungi, parasites, and other microbes constantly change to ensure survival. Several pathogens have adopted strict and intricate strategies to fight medical treatments. Many drugs, frequently prescribed to treat these pathogens, are becoming obsolete and ineffective. Because pathogens have gained the capacity to tolerate or resist medications targeted at them, hence the term antimicrobial resistance (AMR), in that regard, many natural compounds have been routinely used as new antimicrobial agents to treat infections. Thus, plant lectins, the carbohydrate-binding proteins, have been targeted as promising drug candidates. This article reviewed more than 150 published papers on plant lectins with promising antibacterial and antifungal properties. We have also demonstrated how some plant lectins could express a synergistic action as adjuvants to boost the efficacy of obsolete or abandoned antimicrobial drugs. Emphasis has also been given to their plausible mechanism of action. The study further reports on the immunomodulatory effect of plant lectins and how they boost the immune system to curb or prevent infection.http://www.sciencedirect.com/science/article/pii/S0753332222011246PlantLectinsBacteriaFungalInfectionAntimicrobial |
| spellingShingle | Emadeldin Hassan E. Konozy Makarim El-fadil M. Osman Amina I. Dirar George Ghartey-Kwansah Plant lectins: A new antimicrobial frontier Biomedicine & Pharmacotherapy Plant Lectins Bacteria Fungal Infection Antimicrobial |
| title | Plant lectins: A new antimicrobial frontier |
| title_full | Plant lectins: A new antimicrobial frontier |
| title_fullStr | Plant lectins: A new antimicrobial frontier |
| title_full_unstemmed | Plant lectins: A new antimicrobial frontier |
| title_short | Plant lectins: A new antimicrobial frontier |
| title_sort | plant lectins a new antimicrobial frontier |
| topic | Plant Lectins Bacteria Fungal Infection Antimicrobial |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222011246 |
| work_keys_str_mv | AT emadeldinhassanekonozy plantlectinsanewantimicrobialfrontier AT makarimelfadilmosman plantlectinsanewantimicrobialfrontier AT aminaidirar plantlectinsanewantimicrobialfrontier AT georgegharteykwansah plantlectinsanewantimicrobialfrontier |