Serum levels of ghrelin and LEAP2 in patients with type 2 diabetes mellitus: correlation with circulating glucose and lipids
Objective: Ghrelin regulates body weight, food intake, and blood glucose. It also regulates insulin secretion from pancreatic islet cells. LEAP2 is a newly discovered endogenous ligand of the growth hormone secretagogue’s receptor (GHSR). It not only antagonizes the stimulation of GHSR by ghrelin bu...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2022-05-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/11/5/EC-22-0012.xml |
| _version_ | 1817990962389975040 |
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| author | Jiaxi Li Pu Huang Jing Xiong Xinyue Liang Mei Li Hao Ke Chunli Chen Yang Han Yanhong Huang Yan Zhou Ziqiang Luo Dandan Feng Chen Chen |
| author_facet | Jiaxi Li Pu Huang Jing Xiong Xinyue Liang Mei Li Hao Ke Chunli Chen Yang Han Yanhong Huang Yan Zhou Ziqiang Luo Dandan Feng Chen Chen |
| author_sort | Jiaxi Li |
| collection | DOAJ |
| description | Objective: Ghrelin regulates body weight, food intake, and blood glucose. It also regulates insulin secretion from pancreatic islet cells. LEAP2 is a newly discovered endogenous ligand of the growth hormone secretagogue’s receptor (GHSR). It not only antagonizes the stimulation of GHSR by ghrelin but also inhibits the constitutive activation of GHSR as an inverse agonist. Type 2 diabetes (T2D) patients have endocrine disorders with metabolic imbalance. Plasma levels of ghrelin and LEAP2 may be changed in obese and T2D patients. However, there is no report yet on circulating LEAP2 levels or ghrelin/ LEAP2 ratio in T2D patients. In this study, fasting serum ghrelin and LEAP2 levels in healthy adults and T2D patients were assessed to clarify the association of two hormones with different clinical anthropometric and metabolic pa rameters.
Design: A total of 16 females and 40 males, ages 23–68 years old normal (n = 27), and T2D patients (n = 29) were enrolled as a cross-sectional cohort.
Results: Serum levels of ghrelin were lower but serum levels of LEAP2 were higher in T2D patients. Ghrelin levels were positively correlated with fasting serum insulin levels and HOMA-IR in healthy adults. LEAP2 levels were positively cor related with age and hemoglobin A1c (HbA1c) in all tested samples. Ghrelin/LEAP2 ratio was negatively correlated with age, fasting blood glucose, and HbA1c.
Conclusions: This study demonstrated a decrease in serum ghrelin levels and an increase in serum LEAP2 levels in T2D patients. LEAP2 levels were positively correlated with HbA1c, suggesting that LEAP2 was associated with T2D development. The ghrelin/LEAP2 ratio was closely associated with glycemic control in T2D patients showing a negative correlation with glucose and HbA1c. |
| first_indexed | 2024-04-14T01:06:02Z |
| format | Article |
| id | doaj.art-27074ca11dac4368818e8cab2deb8a66 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 |
| language | English |
| last_indexed | 2024-04-14T01:06:02Z |
| publishDate | 2022-05-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-27074ca11dac4368818e8cab2deb8a662022-12-22T02:21:13ZengBioscientificaEndocrine Connections2049-36142022-05-0111519https://doi.org/10.1530/EC-22-0012Serum levels of ghrelin and LEAP2 in patients with type 2 diabetes mellitus: correlation with circulating glucose and lipidsJiaxi Li0Pu Huang1Jing Xiong2Xinyue Liang3Mei Li4Hao Ke5Chunli Chen6Yang Han7Yanhong Huang8Yan Zhou9Ziqiang Luo10Dandan Feng11Chen Chen12Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, ChinaDepartment of Health Management Center, Changsha Central Hospital, University of South China, Changsha, Hunan, ChinaDepartment of Endocrinology, Xiangya Third Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, ChinaDepartment of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, ChinaDepartment of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, ChinaDepartment of Dermatology, Xiangya Third Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, ChinaDepartment of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, ChinaDepartment of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, ChinaDepartment of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Organ Fibrosis, Central South University, Changsha, Hunan, China Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Organ Fibrosis, Central South University, Changsha, Hunan, China School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Queensland, AustraliaObjective: Ghrelin regulates body weight, food intake, and blood glucose. It also regulates insulin secretion from pancreatic islet cells. LEAP2 is a newly discovered endogenous ligand of the growth hormone secretagogue’s receptor (GHSR). It not only antagonizes the stimulation of GHSR by ghrelin but also inhibits the constitutive activation of GHSR as an inverse agonist. Type 2 diabetes (T2D) patients have endocrine disorders with metabolic imbalance. Plasma levels of ghrelin and LEAP2 may be changed in obese and T2D patients. However, there is no report yet on circulating LEAP2 levels or ghrelin/ LEAP2 ratio in T2D patients. In this study, fasting serum ghrelin and LEAP2 levels in healthy adults and T2D patients were assessed to clarify the association of two hormones with different clinical anthropometric and metabolic pa rameters. Design: A total of 16 females and 40 males, ages 23–68 years old normal (n = 27), and T2D patients (n = 29) were enrolled as a cross-sectional cohort. Results: Serum levels of ghrelin were lower but serum levels of LEAP2 were higher in T2D patients. Ghrelin levels were positively correlated with fasting serum insulin levels and HOMA-IR in healthy adults. LEAP2 levels were positively cor related with age and hemoglobin A1c (HbA1c) in all tested samples. Ghrelin/LEAP2 ratio was negatively correlated with age, fasting blood glucose, and HbA1c. Conclusions: This study demonstrated a decrease in serum ghrelin levels and an increase in serum LEAP2 levels in T2D patients. LEAP2 levels were positively correlated with HbA1c, suggesting that LEAP2 was associated with T2D development. The ghrelin/LEAP2 ratio was closely associated with glycemic control in T2D patients showing a negative correlation with glucose and HbA1c.https://ec.bioscientifica.com/view/journals/ec/11/5/EC-22-0012.xmlghrelint2dglucoseleap2correlation |
| spellingShingle | Jiaxi Li Pu Huang Jing Xiong Xinyue Liang Mei Li Hao Ke Chunli Chen Yang Han Yanhong Huang Yan Zhou Ziqiang Luo Dandan Feng Chen Chen Serum levels of ghrelin and LEAP2 in patients with type 2 diabetes mellitus: correlation with circulating glucose and lipids Endocrine Connections ghrelin t2d glucose leap2 correlation |
| title | Serum levels of ghrelin and LEAP2 in patients with type 2 diabetes mellitus: correlation with circulating glucose and lipids |
| title_full | Serum levels of ghrelin and LEAP2 in patients with type 2 diabetes mellitus: correlation with circulating glucose and lipids |
| title_fullStr | Serum levels of ghrelin and LEAP2 in patients with type 2 diabetes mellitus: correlation with circulating glucose and lipids |
| title_full_unstemmed | Serum levels of ghrelin and LEAP2 in patients with type 2 diabetes mellitus: correlation with circulating glucose and lipids |
| title_short | Serum levels of ghrelin and LEAP2 in patients with type 2 diabetes mellitus: correlation with circulating glucose and lipids |
| title_sort | serum levels of ghrelin and leap2 in patients with type 2 diabetes mellitus correlation with circulating glucose and lipids |
| topic | ghrelin t2d glucose leap2 correlation |
| url | https://ec.bioscientifica.com/view/journals/ec/11/5/EC-22-0012.xml |
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