Clinical and radiological outcome following pneumothorax after endoscopic lung volume reduction with valves
D Gompelmann,1,2 N Benjamin,1 K Kontogianni,1 FJF Herth,1,2 CP Heussel,2–4 H Hoffmann,2,5 R Eberhardt1,2 1Pneumology and Critical Care Medicine, Thoraxklinik at University of Heidelberg, 2German Center for Lung Research, 3Diagnostic and Interventional Radiology, Thoraxklinik at U...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-12-01
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| Series: | International Journal of COPD |
| Subjects: | |
| Online Access: | https://www.dovepress.com/clinical-and-radiological-outcome-following-pneumothorax-after-endosco-peer-reviewed-article-COPD |
| _version_ | 1819114305791983616 |
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| author | Gompelmann D Benjamin N Kontogianni K Herth FJF Heussel CP Hoffmann H Eberhardt R |
| author_facet | Gompelmann D Benjamin N Kontogianni K Herth FJF Heussel CP Hoffmann H Eberhardt R |
| author_sort | Gompelmann D |
| collection | DOAJ |
| description | D Gompelmann,1,2 N Benjamin,1 K Kontogianni,1 FJF Herth,1,2 CP Heussel,2–4 H Hoffmann,2,5 R Eberhardt1,2 1Pneumology and Critical Care Medicine, Thoraxklinik at University of Heidelberg, 2German Center for Lung Research, 3Diagnostic and Interventional Radiology, Thoraxklinik at University of Heidelberg, 4Diagnostic and Interventional Radiology, University Hospital Heidelberg, 5Thoracic Surgery, Thoraxklinik at University of Heidelberg, Heidelberg, Germany Introduction: Valve implantation has evolved as a therapy for patients with advanced emphysema. Although it is a minimally invasive treatment, it is associated with complications, the most common being pneumothorax. Pneumothorax occurs due to the rapid target lobe volume reduction and may be a predictor of clinical benefit despite this complication. Objective: The objective of this study was to conduct an exploratory data analysis of patients who developed a pneumothorax following endoscopic valve therapy for emphysema. Materials and methods: This study performed a retrospective evaluation of pneumothorax management and the impact of pneumothorax on clinical outcomes in 70 patients following valve therapy in 381 consecutive patients. Results: Pneumothorax rate following valve therapy was 18%. Pneumothorax management consisted of chest tube insertion, valve removal, and surgical intervention in 87% (61/70), 44% (31/70), and 19% (13/70) of the patients, respectively. Despite pneumothorax, patients experienced modest but significant improvements in lung function parameters (forced expiratory volume in 1 second: 55±148 mL, residual volume: -390±964 mL, total lung capacity: -348±876; all P<0.05). Persistent lobar atelectasis 3 months after recovering from pneumothorax, which was associated with relevant clinical improvement, was observed in only 21% (15/70) of the patients. Conclusion: Pneumothorax is a frequent severe complication following valve therapy that requires further intervention. Nevertheless, the pneumothorax does not impair the clinical status in the majority of patients. Patients with lobar atelectasis benefit after recovering from pneumothorax in terms of lung function parameters. Keywords: COPD, emphysema, endoscopic valve therapy, pneumothorax |
| first_indexed | 2024-12-22T04:43:12Z |
| format | Article |
| id | doaj.art-2707a9ed44024c0fb8ccd5cab2c1c3bc |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-12-22T04:43:12Z |
| publishDate | 2016-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-2707a9ed44024c0fb8ccd5cab2c1c3bc2022-12-21T18:38:41ZengDove Medical PressInternational Journal of COPD1178-20052016-12-01Volume 113093309930378Clinical and radiological outcome following pneumothorax after endoscopic lung volume reduction with valvesGompelmann DBenjamin NKontogianni KHerth FJFHeussel CPHoffmann HEberhardt RD Gompelmann,1,2 N Benjamin,1 K Kontogianni,1 FJF Herth,1,2 CP Heussel,2–4 H Hoffmann,2,5 R Eberhardt1,2 1Pneumology and Critical Care Medicine, Thoraxklinik at University of Heidelberg, 2German Center for Lung Research, 3Diagnostic and Interventional Radiology, Thoraxklinik at University of Heidelberg, 4Diagnostic and Interventional Radiology, University Hospital Heidelberg, 5Thoracic Surgery, Thoraxklinik at University of Heidelberg, Heidelberg, Germany Introduction: Valve implantation has evolved as a therapy for patients with advanced emphysema. Although it is a minimally invasive treatment, it is associated with complications, the most common being pneumothorax. Pneumothorax occurs due to the rapid target lobe volume reduction and may be a predictor of clinical benefit despite this complication. Objective: The objective of this study was to conduct an exploratory data analysis of patients who developed a pneumothorax following endoscopic valve therapy for emphysema. Materials and methods: This study performed a retrospective evaluation of pneumothorax management and the impact of pneumothorax on clinical outcomes in 70 patients following valve therapy in 381 consecutive patients. Results: Pneumothorax rate following valve therapy was 18%. Pneumothorax management consisted of chest tube insertion, valve removal, and surgical intervention in 87% (61/70), 44% (31/70), and 19% (13/70) of the patients, respectively. Despite pneumothorax, patients experienced modest but significant improvements in lung function parameters (forced expiratory volume in 1 second: 55±148 mL, residual volume: -390±964 mL, total lung capacity: -348±876; all P<0.05). Persistent lobar atelectasis 3 months after recovering from pneumothorax, which was associated with relevant clinical improvement, was observed in only 21% (15/70) of the patients. Conclusion: Pneumothorax is a frequent severe complication following valve therapy that requires further intervention. Nevertheless, the pneumothorax does not impair the clinical status in the majority of patients. Patients with lobar atelectasis benefit after recovering from pneumothorax in terms of lung function parameters. Keywords: COPD, emphysema, endoscopic valve therapy, pneumothoraxhttps://www.dovepress.com/clinical-and-radiological-outcome-following-pneumothorax-after-endosco-peer-reviewed-article-COPDCOPDemphysemaendoscopic valve therapypneumothorax |
| spellingShingle | Gompelmann D Benjamin N Kontogianni K Herth FJF Heussel CP Hoffmann H Eberhardt R Clinical and radiological outcome following pneumothorax after endoscopic lung volume reduction with valves International Journal of COPD COPD emphysema endoscopic valve therapy pneumothorax |
| title | Clinical and radiological outcome following pneumothorax after endoscopic lung volume reduction with valves |
| title_full | Clinical and radiological outcome following pneumothorax after endoscopic lung volume reduction with valves |
| title_fullStr | Clinical and radiological outcome following pneumothorax after endoscopic lung volume reduction with valves |
| title_full_unstemmed | Clinical and radiological outcome following pneumothorax after endoscopic lung volume reduction with valves |
| title_short | Clinical and radiological outcome following pneumothorax after endoscopic lung volume reduction with valves |
| title_sort | clinical and radiological outcome following pneumothorax after endoscopic lung volume reduction with valves |
| topic | COPD emphysema endoscopic valve therapy pneumothorax |
| url | https://www.dovepress.com/clinical-and-radiological-outcome-following-pneumothorax-after-endosco-peer-reviewed-article-COPD |
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