REM sleep is associated with white matter integrity in cognitively healthy, older adults.
There is increasing awareness that self-reported sleep abnormalities are negatively associated with brain structure and function in older adults. Less is known, however, about how objectively measured sleep associates with brain structure. We objectively measured at-home sleep to investigate how sle...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0235395 |
| _version_ | 1818901668550410240 |
|---|---|
| author | Marie Altendahl Devyn L Cotter Adam M Staffaroni Amy Wolf Paige Mumford Yann Cobigo Kaitlin Casaletto Fanny Elahi Leslie Ruoff Samirah Javed Brianne M Bettcher Emily Fox Michelle You Rowan Saloner Thomas C Neylan Joel H Kramer Christine M Walsh |
| author_facet | Marie Altendahl Devyn L Cotter Adam M Staffaroni Amy Wolf Paige Mumford Yann Cobigo Kaitlin Casaletto Fanny Elahi Leslie Ruoff Samirah Javed Brianne M Bettcher Emily Fox Michelle You Rowan Saloner Thomas C Neylan Joel H Kramer Christine M Walsh |
| author_sort | Marie Altendahl |
| collection | DOAJ |
| description | There is increasing awareness that self-reported sleep abnormalities are negatively associated with brain structure and function in older adults. Less is known, however, about how objectively measured sleep associates with brain structure. We objectively measured at-home sleep to investigate how sleep architecture and sleep quality related to white matter microstructure in older adults. 43 cognitively normal, older adults underwent diffusion tensor imaging (DTI) and a sleep assessment within a six-month period. Participants completed the PSQI, a subjective measure of sleep quality, and used an at-home sleep recorder (Zeo, Inc.) to measure total sleep time (TST), sleep efficiency (SE), and percent time in light sleep (LS), deep sleep (DS), and REM sleep (RS). Multiple regressions predicted fractional anisotropy (FA) and mean diffusivity (MD) of the corpus callosum as a function of total PSQI score, TST, SE, and percent of time spent in each sleep stage, controlling for age and sex. Greater percent time spent in RS was significantly associated with higher FA (β = 0.41, p = 0.007) and lower MD (β = -0.30, p = 0.03). Total PSQI score, TST, SE, and time spent in LS or DS were not significantly associated with FA or MD (p>0.13). Percent time spent in REM sleep, but not quantity of light and deep sleep or subjective/objective measures of sleep quality, positively predicted white matter microstructure integrity. Our results highlight an important link between REM sleep and brain health that has the potential to improve sleep interventions in the elderly. |
| first_indexed | 2024-12-19T20:23:25Z |
| format | Article |
| id | doaj.art-2708130bbd1c46e49e90854d084e82b8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T20:23:25Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2708130bbd1c46e49e90854d084e82b82022-12-21T20:06:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01157e023539510.1371/journal.pone.0235395REM sleep is associated with white matter integrity in cognitively healthy, older adults.Marie AltendahlDevyn L CotterAdam M StaffaroniAmy WolfPaige MumfordYann CobigoKaitlin CasalettoFanny ElahiLeslie RuoffSamirah JavedBrianne M BettcherEmily FoxMichelle YouRowan SalonerThomas C NeylanJoel H KramerChristine M WalshThere is increasing awareness that self-reported sleep abnormalities are negatively associated with brain structure and function in older adults. Less is known, however, about how objectively measured sleep associates with brain structure. We objectively measured at-home sleep to investigate how sleep architecture and sleep quality related to white matter microstructure in older adults. 43 cognitively normal, older adults underwent diffusion tensor imaging (DTI) and a sleep assessment within a six-month period. Participants completed the PSQI, a subjective measure of sleep quality, and used an at-home sleep recorder (Zeo, Inc.) to measure total sleep time (TST), sleep efficiency (SE), and percent time in light sleep (LS), deep sleep (DS), and REM sleep (RS). Multiple regressions predicted fractional anisotropy (FA) and mean diffusivity (MD) of the corpus callosum as a function of total PSQI score, TST, SE, and percent of time spent in each sleep stage, controlling for age and sex. Greater percent time spent in RS was significantly associated with higher FA (β = 0.41, p = 0.007) and lower MD (β = -0.30, p = 0.03). Total PSQI score, TST, SE, and time spent in LS or DS were not significantly associated with FA or MD (p>0.13). Percent time spent in REM sleep, but not quantity of light and deep sleep or subjective/objective measures of sleep quality, positively predicted white matter microstructure integrity. Our results highlight an important link between REM sleep and brain health that has the potential to improve sleep interventions in the elderly.https://doi.org/10.1371/journal.pone.0235395 |
| spellingShingle | Marie Altendahl Devyn L Cotter Adam M Staffaroni Amy Wolf Paige Mumford Yann Cobigo Kaitlin Casaletto Fanny Elahi Leslie Ruoff Samirah Javed Brianne M Bettcher Emily Fox Michelle You Rowan Saloner Thomas C Neylan Joel H Kramer Christine M Walsh REM sleep is associated with white matter integrity in cognitively healthy, older adults. PLoS ONE |
| title | REM sleep is associated with white matter integrity in cognitively healthy, older adults. |
| title_full | REM sleep is associated with white matter integrity in cognitively healthy, older adults. |
| title_fullStr | REM sleep is associated with white matter integrity in cognitively healthy, older adults. |
| title_full_unstemmed | REM sleep is associated with white matter integrity in cognitively healthy, older adults. |
| title_short | REM sleep is associated with white matter integrity in cognitively healthy, older adults. |
| title_sort | rem sleep is associated with white matter integrity in cognitively healthy older adults |
| url | https://doi.org/10.1371/journal.pone.0235395 |
| work_keys_str_mv | AT mariealtendahl remsleepisassociatedwithwhitematterintegrityincognitivelyhealthyolderadults AT devynlcotter remsleepisassociatedwithwhitematterintegrityincognitivelyhealthyolderadults AT adammstaffaroni remsleepisassociatedwithwhitematterintegrityincognitivelyhealthyolderadults AT amywolf remsleepisassociatedwithwhitematterintegrityincognitivelyhealthyolderadults AT paigemumford remsleepisassociatedwithwhitematterintegrityincognitivelyhealthyolderadults AT yanncobigo remsleepisassociatedwithwhitematterintegrityincognitivelyhealthyolderadults AT kaitlincasaletto remsleepisassociatedwithwhitematterintegrityincognitivelyhealthyolderadults AT fannyelahi remsleepisassociatedwithwhitematterintegrityincognitivelyhealthyolderadults AT leslieruoff remsleepisassociatedwithwhitematterintegrityincognitivelyhealthyolderadults AT samirahjaved remsleepisassociatedwithwhitematterintegrityincognitivelyhealthyolderadults AT briannembettcher remsleepisassociatedwithwhitematterintegrityincognitivelyhealthyolderadults AT emilyfox remsleepisassociatedwithwhitematterintegrityincognitivelyhealthyolderadults AT michelleyou remsleepisassociatedwithwhitematterintegrityincognitivelyhealthyolderadults AT rowansaloner remsleepisassociatedwithwhitematterintegrityincognitivelyhealthyolderadults AT thomascneylan remsleepisassociatedwithwhitematterintegrityincognitivelyhealthyolderadults AT joelhkramer remsleepisassociatedwithwhitematterintegrityincognitivelyhealthyolderadults AT christinemwalsh remsleepisassociatedwithwhitematterintegrityincognitivelyhealthyolderadults |