Volumetric registration framework for multimodal functional magnetic resonance and optoacoustic tomography of the rodent brain
Optoacoustic tomography (OAT) provides a non-invasive means to characterize cerebral hemodynamics across an entire murine brain while attaining multi-parametric readouts not available with other modalities. This unique capability can massively impact our understanding of brain function. However, OAT...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Photoacoustics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213597923000757 |
| _version_ | 1797801026509602816 |
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| author | Irmak Gezginer Zhenyue Chen Hikari A.I. Yoshihara Xosé Luís Deán-Ben Daniel Razansky |
| author_facet | Irmak Gezginer Zhenyue Chen Hikari A.I. Yoshihara Xosé Luís Deán-Ben Daniel Razansky |
| author_sort | Irmak Gezginer |
| collection | DOAJ |
| description | Optoacoustic tomography (OAT) provides a non-invasive means to characterize cerebral hemodynamics across an entire murine brain while attaining multi-parametric readouts not available with other modalities. This unique capability can massively impact our understanding of brain function. However, OAT largely lacks the soft tissue contrast required for unambiguous identification of brain regions. Hence, its accurate registration to a reference brain atlas is paramount for attaining meaningful functional readings. Herein, we capitalized on the simultaneously acquired bi-modal data from the recently-developed hybrid magnetic resonance optoacoustic tomography (MROT) scanner in order to devise an image coregistration paradigm that facilitates brain parcellation and anatomical referencing. We evaluated the performance of the proposed methodology by coregistering OAT data acquired with a standalone system using different registration methods. The enhanced performance is further demonstrated for functional OAT data analysis and characterization of stimulus-evoked brain responses. The suggested approach enables better consolidation of the research findings thus facilitating wider acceptance of OAT as a powerful neuroimaging tool to study brain functions and diseases. |
| first_indexed | 2024-03-13T04:44:09Z |
| format | Article |
| id | doaj.art-2708da7927c64a96aa4f67427ad3de20 |
| institution | Directory Open Access Journal |
| issn | 2213-5979 |
| language | English |
| last_indexed | 2024-03-13T04:44:09Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photoacoustics |
| spelling | doaj.art-2708da7927c64a96aa4f67427ad3de202023-06-19T04:28:09ZengElsevierPhotoacoustics2213-59792023-06-0131100522Volumetric registration framework for multimodal functional magnetic resonance and optoacoustic tomography of the rodent brainIrmak Gezginer0Zhenyue Chen1Hikari A.I. Yoshihara2Xosé Luís Deán-Ben3Daniel Razansky4Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, SwitzerlandInstitute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, SwitzerlandInstitute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, SwitzerlandInstitute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, SwitzerlandInstitute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, Switzerland; Correspondence to: Daniel Razansky, Institute for Biomedical Engineering, Wolfgang-Pauli-Strasse 27, CH-8093 Zurich, Switzerland.Optoacoustic tomography (OAT) provides a non-invasive means to characterize cerebral hemodynamics across an entire murine brain while attaining multi-parametric readouts not available with other modalities. This unique capability can massively impact our understanding of brain function. However, OAT largely lacks the soft tissue contrast required for unambiguous identification of brain regions. Hence, its accurate registration to a reference brain atlas is paramount for attaining meaningful functional readings. Herein, we capitalized on the simultaneously acquired bi-modal data from the recently-developed hybrid magnetic resonance optoacoustic tomography (MROT) scanner in order to devise an image coregistration paradigm that facilitates brain parcellation and anatomical referencing. We evaluated the performance of the proposed methodology by coregistering OAT data acquired with a standalone system using different registration methods. The enhanced performance is further demonstrated for functional OAT data analysis and characterization of stimulus-evoked brain responses. The suggested approach enables better consolidation of the research findings thus facilitating wider acceptance of OAT as a powerful neuroimaging tool to study brain functions and diseases.http://www.sciencedirect.com/science/article/pii/S2213597923000757Optoacoustic tomographyMagnetic resonance imagingMultimodal imagingImage registrationMouse brain templateMouse brain atlas |
| spellingShingle | Irmak Gezginer Zhenyue Chen Hikari A.I. Yoshihara Xosé Luís Deán-Ben Daniel Razansky Volumetric registration framework for multimodal functional magnetic resonance and optoacoustic tomography of the rodent brain Photoacoustics Optoacoustic tomography Magnetic resonance imaging Multimodal imaging Image registration Mouse brain template Mouse brain atlas |
| title | Volumetric registration framework for multimodal functional magnetic resonance and optoacoustic tomography of the rodent brain |
| title_full | Volumetric registration framework for multimodal functional magnetic resonance and optoacoustic tomography of the rodent brain |
| title_fullStr | Volumetric registration framework for multimodal functional magnetic resonance and optoacoustic tomography of the rodent brain |
| title_full_unstemmed | Volumetric registration framework for multimodal functional magnetic resonance and optoacoustic tomography of the rodent brain |
| title_short | Volumetric registration framework for multimodal functional magnetic resonance and optoacoustic tomography of the rodent brain |
| title_sort | volumetric registration framework for multimodal functional magnetic resonance and optoacoustic tomography of the rodent brain |
| topic | Optoacoustic tomography Magnetic resonance imaging Multimodal imaging Image registration Mouse brain template Mouse brain atlas |
| url | http://www.sciencedirect.com/science/article/pii/S2213597923000757 |
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