Asymmetric Pattern of Correlations of Leucine Aminopeptidase Activity between Left or Right Frontal Cortex versus Diverse Left or Right Regions of Rat Brains
Previous studies demonstrated an asymmetry of left predominance for mean values of soluble leucine aminopeptidase (LeuAP) activity in the frontal cortex (FC) and hypothalamus of adult male rats, fluorimetrically analyzed by the hydrolysis of Leu-β-naphthylamide as a substrate. No asymmetries were ob...
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MDPI AG
2023-06-01
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| Series: | Symmetry |
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| Online Access: | https://www.mdpi.com/2073-8994/15/7/1320 |
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| author | Manuel Ramírez-Sánchez Isabel Prieto Ana Belén Segarra Inmaculada Banegas Magdalena Martínez-Cañamero Germán Domínguez-Vías Raquel Durán Francisco Vives Francisco Alba |
| author_facet | Manuel Ramírez-Sánchez Isabel Prieto Ana Belén Segarra Inmaculada Banegas Magdalena Martínez-Cañamero Germán Domínguez-Vías Raquel Durán Francisco Vives Francisco Alba |
| author_sort | Manuel Ramírez-Sánchez |
| collection | DOAJ |
| description | Previous studies demonstrated an asymmetry of left predominance for mean values of soluble leucine aminopeptidase (LeuAP) activity in the frontal cortex (FC) and hypothalamus of adult male rats, fluorimetrically analyzed by the hydrolysis of Leu-β-naphthylamide as a substrate. No asymmetries were observed in nine other left (L) and right (R) regions obtained from rostro-caudally sectioned coronal slices. Neither had inter-hemispheric differences observed for lactate dehydrogenase (LDH), analyzed simultaneously in the same brain regions (L and R) of the same animals. However, the level of intra-hemispheric or inter-hemispheric correlation of LeuAP or LDH between such brain regions has not been analyzed. In order to obtain additional suggestions on the functional heterogeneity between regions of LeuAP and LDH, in the present investigation, the level of intra-hemispheric and inter-hemispheric correlations of the frontal cortex with the rest of the regions studied is described: (A) between the left frontal cortex (LFC) and the rest of the left regions; (B) between the right frontal cortex (RFC) and the rest of the right regions; (C) between the left frontal cortex and all of the right regions; and (D) between the right frontal cortex and all of the left regions. All of the correlations obtained were positive. The intra-hemispheric analysis showed a greater heterogeneity of values in the correlations observed between RFC and the rest of the right regions than between LFC and the rest of the left regions. Greater heterogeneity is observed when comparing RFC correlations with left regions than when comparing LFC correlations with right regions. In conclusion, the greatest heterogeneity (suggesting a greater functional variability) was observed in the right intra-hemispheric analysis and in the inter-hemispheric analysis between the RFC and the left hemisphere. The results for LDH showed a great homogeneity between regions both in the intra- and inter-hemispheric studies. |
| first_indexed | 2024-03-11T00:35:57Z |
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| id | doaj.art-270a0cc18a9b47c7881a84fb09b663f4 |
| institution | Directory Open Access Journal |
| issn | 2073-8994 |
| language | English |
| last_indexed | 2024-03-11T00:35:57Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Symmetry |
| spelling | doaj.art-270a0cc18a9b47c7881a84fb09b663f42023-11-18T21:33:28ZengMDPI AGSymmetry2073-89942023-06-01157132010.3390/sym15071320Asymmetric Pattern of Correlations of Leucine Aminopeptidase Activity between Left or Right Frontal Cortex versus Diverse Left or Right Regions of Rat BrainsManuel Ramírez-Sánchez0Isabel Prieto1Ana Belén Segarra2Inmaculada Banegas3Magdalena Martínez-Cañamero4Germán Domínguez-Vías5Raquel Durán6Francisco Vives7Francisco Alba8Department of Health Sciences, University of Jaén, 23071 Jaén, SpainDepartment of Health Sciences, University of Jaén, 23071 Jaén, SpainDepartment of Health Sciences, University of Jaén, 23071 Jaén, SpainDepartment of Health Sciences, University of Jaén, 23071 Jaén, SpainDepartment of Health Sciences, University of Jaén, 23071 Jaén, SpainDepartment of Physiology, Faculty of Health Sciences, Ceuta, University of Granada, 18071 Granada, SpainDepartment of Physiology, Faculty of Medicine, University of Granada, 18071 Granada, SpainDepartment of Physiology, Faculty of Medicine, University of Granada, 18071 Granada, SpainDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, 18071 Granada, SpainPrevious studies demonstrated an asymmetry of left predominance for mean values of soluble leucine aminopeptidase (LeuAP) activity in the frontal cortex (FC) and hypothalamus of adult male rats, fluorimetrically analyzed by the hydrolysis of Leu-β-naphthylamide as a substrate. No asymmetries were observed in nine other left (L) and right (R) regions obtained from rostro-caudally sectioned coronal slices. Neither had inter-hemispheric differences observed for lactate dehydrogenase (LDH), analyzed simultaneously in the same brain regions (L and R) of the same animals. However, the level of intra-hemispheric or inter-hemispheric correlation of LeuAP or LDH between such brain regions has not been analyzed. In order to obtain additional suggestions on the functional heterogeneity between regions of LeuAP and LDH, in the present investigation, the level of intra-hemispheric and inter-hemispheric correlations of the frontal cortex with the rest of the regions studied is described: (A) between the left frontal cortex (LFC) and the rest of the left regions; (B) between the right frontal cortex (RFC) and the rest of the right regions; (C) between the left frontal cortex and all of the right regions; and (D) between the right frontal cortex and all of the left regions. All of the correlations obtained were positive. The intra-hemispheric analysis showed a greater heterogeneity of values in the correlations observed between RFC and the rest of the right regions than between LFC and the rest of the left regions. Greater heterogeneity is observed when comparing RFC correlations with left regions than when comparing LFC correlations with right regions. In conclusion, the greatest heterogeneity (suggesting a greater functional variability) was observed in the right intra-hemispheric analysis and in the inter-hemispheric analysis between the RFC and the left hemisphere. The results for LDH showed a great homogeneity between regions both in the intra- and inter-hemispheric studies.https://www.mdpi.com/2073-8994/15/7/1320brain asymmetryintra-hemispheric correlationsinter-hemispheric correlationsleucine aminopeptidaselactate dehydrogenasebrain heterogeneity |
| spellingShingle | Manuel Ramírez-Sánchez Isabel Prieto Ana Belén Segarra Inmaculada Banegas Magdalena Martínez-Cañamero Germán Domínguez-Vías Raquel Durán Francisco Vives Francisco Alba Asymmetric Pattern of Correlations of Leucine Aminopeptidase Activity between Left or Right Frontal Cortex versus Diverse Left or Right Regions of Rat Brains Symmetry brain asymmetry intra-hemispheric correlations inter-hemispheric correlations leucine aminopeptidase lactate dehydrogenase brain heterogeneity |
| title | Asymmetric Pattern of Correlations of Leucine Aminopeptidase Activity between Left or Right Frontal Cortex versus Diverse Left or Right Regions of Rat Brains |
| title_full | Asymmetric Pattern of Correlations of Leucine Aminopeptidase Activity between Left or Right Frontal Cortex versus Diverse Left or Right Regions of Rat Brains |
| title_fullStr | Asymmetric Pattern of Correlations of Leucine Aminopeptidase Activity between Left or Right Frontal Cortex versus Diverse Left or Right Regions of Rat Brains |
| title_full_unstemmed | Asymmetric Pattern of Correlations of Leucine Aminopeptidase Activity between Left or Right Frontal Cortex versus Diverse Left or Right Regions of Rat Brains |
| title_short | Asymmetric Pattern of Correlations of Leucine Aminopeptidase Activity between Left or Right Frontal Cortex versus Diverse Left or Right Regions of Rat Brains |
| title_sort | asymmetric pattern of correlations of leucine aminopeptidase activity between left or right frontal cortex versus diverse left or right regions of rat brains |
| topic | brain asymmetry intra-hemispheric correlations inter-hemispheric correlations leucine aminopeptidase lactate dehydrogenase brain heterogeneity |
| url | https://www.mdpi.com/2073-8994/15/7/1320 |
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