Structural and Functional NIR-II Fluorescence Bioimaging in Urinary System via Clinically Approved Dye Methylene Blue
Accurate structural and functional imaging is vital for the diagnosis and prognosis of urinary system diseases. Fluorescence bioimaging in the second near-infrared spectral region (NIR-II, 1000–1700 nm) has shown advantages of higher spatial resolution, deeper penetration, and finer signal-to-backgr...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Engineering |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095809922002764 |
| _version_ | 1827953734670352384 |
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| author | Dingwei Xue Di Wu Zeyi Lu Jochen Neuhaus Abudureheman Zebibula Zhe Feng Sheng Cheng Jing Zhou Jun Qian Gonghui Li |
| author_facet | Dingwei Xue Di Wu Zeyi Lu Jochen Neuhaus Abudureheman Zebibula Zhe Feng Sheng Cheng Jing Zhou Jun Qian Gonghui Li |
| author_sort | Dingwei Xue |
| collection | DOAJ |
| description | Accurate structural and functional imaging is vital for the diagnosis and prognosis of urinary system diseases. Fluorescence bioimaging in the second near-infrared spectral region (NIR-II, 1000–1700 nm) has shown advantages of higher spatial resolution, deeper penetration, and finer signal-to-background ratio (SBR) compared to the conventional fluorescence imaging methods but limited to its clinical inapplicability. Herein, we first report in vivo NIR-II fluorescence imaging of the urinary system enabled by a clinically approved and renal excretable dye methylene blue (MB), which cannot only achieve clear invasive/non-invasive urography but also noninvasively detect renal function efficiently. These results demonstrate that MB assisted NIR-II fluorescence imaging holds a great promise for structural and functional imaging of the urinary system both clinically and preclinically. |
| first_indexed | 2024-04-09T14:18:13Z |
| format | Article |
| id | doaj.art-270e0d1958234aa6bb543f267f33003b |
| institution | Directory Open Access Journal |
| issn | 2095-8099 |
| language | English |
| last_indexed | 2024-04-09T14:18:13Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Engineering |
| spelling | doaj.art-270e0d1958234aa6bb543f267f33003b2023-05-05T04:40:25ZengElsevierEngineering2095-80992023-03-0122149158Structural and Functional NIR-II Fluorescence Bioimaging in Urinary System via Clinically Approved Dye Methylene BlueDingwei Xue0Di Wu1Zeyi Lu2Jochen Neuhaus3Abudureheman Zebibula4Zhe Feng5Sheng Cheng6Jing Zhou7Jun Qian8Gonghui Li9Department of Urology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, ChinaDepartment of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, ChinaDepartment of Urology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, ChinaDepartment of Urology, University of Leipzig, Leipzig 04103, GermanyDepartment of Urology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, ChinaState Key Laboratory of Modern Optical Instrumentation, Centre for Optical and Electromagnetic Research, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310058, ChinaDepartment of Urology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, ChinaState Key Laboratory of Modern Optical Instrumentation, Centre for Optical and Electromagnetic Research, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310058, ChinaDepartment of Urology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; State Key Laboratory of Modern Optical Instrumentation, Centre for Optical and Electromagnetic Research, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310058, China; Corresponding authors.Department of Urology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; Corresponding authors.Accurate structural and functional imaging is vital for the diagnosis and prognosis of urinary system diseases. Fluorescence bioimaging in the second near-infrared spectral region (NIR-II, 1000–1700 nm) has shown advantages of higher spatial resolution, deeper penetration, and finer signal-to-background ratio (SBR) compared to the conventional fluorescence imaging methods but limited to its clinical inapplicability. Herein, we first report in vivo NIR-II fluorescence imaging of the urinary system enabled by a clinically approved and renal excretable dye methylene blue (MB), which cannot only achieve clear invasive/non-invasive urography but also noninvasively detect renal function efficiently. These results demonstrate that MB assisted NIR-II fluorescence imaging holds a great promise for structural and functional imaging of the urinary system both clinically and preclinically.http://www.sciencedirect.com/science/article/pii/S2095809922002764NIR-II fluorescenceMethylene blueRenal functionUrinary systemReal-time imaging |
| spellingShingle | Dingwei Xue Di Wu Zeyi Lu Jochen Neuhaus Abudureheman Zebibula Zhe Feng Sheng Cheng Jing Zhou Jun Qian Gonghui Li Structural and Functional NIR-II Fluorescence Bioimaging in Urinary System via Clinically Approved Dye Methylene Blue Engineering NIR-II fluorescence Methylene blue Renal function Urinary system Real-time imaging |
| title | Structural and Functional NIR-II Fluorescence Bioimaging in Urinary System via Clinically Approved Dye Methylene Blue |
| title_full | Structural and Functional NIR-II Fluorescence Bioimaging in Urinary System via Clinically Approved Dye Methylene Blue |
| title_fullStr | Structural and Functional NIR-II Fluorescence Bioimaging in Urinary System via Clinically Approved Dye Methylene Blue |
| title_full_unstemmed | Structural and Functional NIR-II Fluorescence Bioimaging in Urinary System via Clinically Approved Dye Methylene Blue |
| title_short | Structural and Functional NIR-II Fluorescence Bioimaging in Urinary System via Clinically Approved Dye Methylene Blue |
| title_sort | structural and functional nir ii fluorescence bioimaging in urinary system via clinically approved dye methylene blue |
| topic | NIR-II fluorescence Methylene blue Renal function Urinary system Real-time imaging |
| url | http://www.sciencedirect.com/science/article/pii/S2095809922002764 |
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