Hyperhomocysteinemia – A treatable cause of cerebral venous thrombosis in young
Mild hyperhomocysteinemia is an established risk factor for deep vein thrombosis. Here, we report a case of a 28-year-old male with complaints of severe headache and vomiting for 7 days, and he also had two episodes of generalised tonic clonic seizures (GTCS) type of convulsions. Magnetic resonance...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | APIK Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://www.ajim.in/article.asp?issn=2666-1802;year=2020;volume=8;issue=4;spage=209;epage=211;aulast=Kamat |
| _version_ | 1818964819533889536 |
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| author | Vivekanand Kamat Suresh Harsoor |
| author_facet | Vivekanand Kamat Suresh Harsoor |
| author_sort | Vivekanand Kamat |
| collection | DOAJ |
| description | Mild hyperhomocysteinemia is an established risk factor for deep vein thrombosis. Here, we report a case of a 28-year-old male with complaints of severe headache and vomiting for 7 days, and he also had two episodes of generalised tonic clonic seizures (GTCS) type of convulsions. Magnetic resonance imaging + magnetic resonance venography showed acute infarct with hemorrhagic transformation in the right occipital region and venous thrombosis of the right transverse sinus, right sigmoid sinus, and superior sagittal sinus. All laboratory investigations including protein C, S, and B12levels were found to be normal except for serum homocysteine which was 29.20 μmol/L. After anticoagulation therapy, this young patient completely recovered without any residual neurological deficit. Hence, we suggest that hyperhomocysteinemia should also be a risk factor for cerebral venous thrombosis (CVT). Since this condition can be effectively and safely corrected by drugs, we suggest that homocysteine levels should be routinely determined in patients with idiopathic CVT, and even mildly increased levels corrected pharmacologically, in the hope of reducing the risks associated with this condition. |
| first_indexed | 2024-12-20T13:07:10Z |
| format | Article |
| id | doaj.art-270e7c3b989b4bf2a49c9eaa371ed6be |
| institution | Directory Open Access Journal |
| issn | 2666-1802 2666-1810 |
| language | English |
| last_indexed | 2024-12-20T13:07:10Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | APIK Journal of Internal Medicine |
| spelling | doaj.art-270e7c3b989b4bf2a49c9eaa371ed6be2022-12-21T19:39:46ZengWolters Kluwer Medknow PublicationsAPIK Journal of Internal Medicine2666-18022666-18102020-01-018420921110.4103/AJIM.AJIM_62_19Hyperhomocysteinemia – A treatable cause of cerebral venous thrombosis in youngVivekanand KamatSuresh HarsoorMild hyperhomocysteinemia is an established risk factor for deep vein thrombosis. Here, we report a case of a 28-year-old male with complaints of severe headache and vomiting for 7 days, and he also had two episodes of generalised tonic clonic seizures (GTCS) type of convulsions. Magnetic resonance imaging + magnetic resonance venography showed acute infarct with hemorrhagic transformation in the right occipital region and venous thrombosis of the right transverse sinus, right sigmoid sinus, and superior sagittal sinus. All laboratory investigations including protein C, S, and B12levels were found to be normal except for serum homocysteine which was 29.20 μmol/L. After anticoagulation therapy, this young patient completely recovered without any residual neurological deficit. Hence, we suggest that hyperhomocysteinemia should also be a risk factor for cerebral venous thrombosis (CVT). Since this condition can be effectively and safely corrected by drugs, we suggest that homocysteine levels should be routinely determined in patients with idiopathic CVT, and even mildly increased levels corrected pharmacologically, in the hope of reducing the risks associated with this condition.http://www.ajim.in/article.asp?issn=2666-1802;year=2020;volume=8;issue=4;spage=209;epage=211;aulast=Kamatcerebral venous thrombosisgeneralised tonic clonic seizureshyperhomocysteinemia |
| spellingShingle | Vivekanand Kamat Suresh Harsoor Hyperhomocysteinemia – A treatable cause of cerebral venous thrombosis in young APIK Journal of Internal Medicine cerebral venous thrombosis generalised tonic clonic seizures hyperhomocysteinemia |
| title | Hyperhomocysteinemia – A treatable cause of cerebral venous thrombosis in young |
| title_full | Hyperhomocysteinemia – A treatable cause of cerebral venous thrombosis in young |
| title_fullStr | Hyperhomocysteinemia – A treatable cause of cerebral venous thrombosis in young |
| title_full_unstemmed | Hyperhomocysteinemia – A treatable cause of cerebral venous thrombosis in young |
| title_short | Hyperhomocysteinemia – A treatable cause of cerebral venous thrombosis in young |
| title_sort | hyperhomocysteinemia a treatable cause of cerebral venous thrombosis in young |
| topic | cerebral venous thrombosis generalised tonic clonic seizures hyperhomocysteinemia |
| url | http://www.ajim.in/article.asp?issn=2666-1802;year=2020;volume=8;issue=4;spage=209;epage=211;aulast=Kamat |
| work_keys_str_mv | AT vivekanandkamat hyperhomocysteinemiaatreatablecauseofcerebralvenousthrombosisinyoung AT sureshharsoor hyperhomocysteinemiaatreatablecauseofcerebralvenousthrombosisinyoung |