The negative effect of antibiotics on RCC patients with immunotherapy: A systematic review and meta-analysis
BackgroundMicrobiome dysbiosis is considered a predictive biomarker of clinical response in renal cell carcinoma (RCC), which can be regulated by antibiotics (ATB). Multiple studies have shown that concomitant ATB administration has inhibitory effects on immunotherapy in RCC. This review aimed to as...
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1065004/full |
| _version_ | 1811316793394855936 |
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| author | Zhiqiang Luo Siyuan Hao Yuxuan Li Lei Cheng Lei Cheng Xuedong Zhou Xuedong Zhou Emine Gulsen Gunes Shiyu Liu Jing Chen Jing Chen |
| author_facet | Zhiqiang Luo Siyuan Hao Yuxuan Li Lei Cheng Lei Cheng Xuedong Zhou Xuedong Zhou Emine Gulsen Gunes Shiyu Liu Jing Chen Jing Chen |
| author_sort | Zhiqiang Luo |
| collection | DOAJ |
| description | BackgroundMicrobiome dysbiosis is considered a predictive biomarker of clinical response in renal cell carcinoma (RCC), which can be regulated by antibiotics (ATB). Multiple studies have shown that concomitant ATB administration has inhibitory effects on immunotherapy in RCC. This review aimed to assess the impact of ATB on patient survival and tumor response in RCC with immunotherapy.MethodsLiterature evaluating the effect of ATB on immunotherapy in RCC from Cochrane Library®, PubMed®, Embase®, Scopus®, and Web of Science® were systematically searched. Hazard ratios (HR) for progression-free survival (PFS) and overall survival (OS), odds ratio (OR) for objective response rate (ORR) and primary progressive disease (PD) were pooled as effect sizes for clinical outcomes. Subgroup analysis was conducted to reveal the determinants of the effect of ATB on immunotherapy, including time windows of ATB exposure to immunotherapy initiation, ICIs treatment and study location. The leave-one-out approach was adopted to analyze the heterogeneity formulated. Cumulative meta-analysis adding by time was used to observe dynamic changes of the results.ResultsTen studies were included in the systematic review and six studies (with n=1,104 patients) were included in the meta-analysis, four studies were excluded for overlapping patients with subsequent larger studies and lack of unique patient-level data. ATB administration was significantly correlated with shorter PFS (HR=2.10, 95%CI [1.54; 2.85], I2 = 2% after omitting study Derosa et al, 2021 detected by leave-one-out approach), shorter OS (HR=1.69, 95%CI [1.34; 2.12], I2 = 25%) and worse ORR (OR=0.58, 95%CI [0.41; 0.84]), but no difference was observed in risk of PD (OR=1.18, 95%CI [0.97; 1.44]). No significant differences existed among the subgroups for determining the determinants of ATB inhibition.ConclusionsConcomitant ATB with immunotherapy was associated with worse PFS, OS and ORR in RCC. No publication bias was observed in this study.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=349577, identifier CRD42022349577. |
| first_indexed | 2024-04-13T11:55:39Z |
| format | Article |
| id | doaj.art-270f20aab5e24d5d832a789e68958c3d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T11:55:39Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-270f20aab5e24d5d832a789e68958c3d2022-12-22T02:47:55ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-11-011310.3389/fimmu.2022.10650041065004The negative effect of antibiotics on RCC patients with immunotherapy: A systematic review and meta-analysisZhiqiang Luo0Siyuan Hao1Yuxuan Li2Lei Cheng3Lei Cheng4Xuedong Zhou5Xuedong Zhou6Emine Gulsen Gunes7Shiyu Liu8Jing Chen9Jing Chen10State Key Laboratory of Oral Diseases, National Clinical Research for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaSchool of Stomatology, Dalian Medical University, Dalian, ChinaState Key Laboratory of Oral Diseases, National Clinical Research for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaDepartment of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaDepartment of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaDepartment of Hematologic Malignancies Translational Science, City of Hope, Duarte, CA, United StatesKey Laboratory of Oral Biomedical Research of Zhejiang Province, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Cancer Center of Zhejiang University, Hangzhou, ChinaState Key Laboratory of Oral Diseases, National Clinical Research for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaDepartment of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaBackgroundMicrobiome dysbiosis is considered a predictive biomarker of clinical response in renal cell carcinoma (RCC), which can be regulated by antibiotics (ATB). Multiple studies have shown that concomitant ATB administration has inhibitory effects on immunotherapy in RCC. This review aimed to assess the impact of ATB on patient survival and tumor response in RCC with immunotherapy.MethodsLiterature evaluating the effect of ATB on immunotherapy in RCC from Cochrane Library®, PubMed®, Embase®, Scopus®, and Web of Science® were systematically searched. Hazard ratios (HR) for progression-free survival (PFS) and overall survival (OS), odds ratio (OR) for objective response rate (ORR) and primary progressive disease (PD) were pooled as effect sizes for clinical outcomes. Subgroup analysis was conducted to reveal the determinants of the effect of ATB on immunotherapy, including time windows of ATB exposure to immunotherapy initiation, ICIs treatment and study location. The leave-one-out approach was adopted to analyze the heterogeneity formulated. Cumulative meta-analysis adding by time was used to observe dynamic changes of the results.ResultsTen studies were included in the systematic review and six studies (with n=1,104 patients) were included in the meta-analysis, four studies were excluded for overlapping patients with subsequent larger studies and lack of unique patient-level data. ATB administration was significantly correlated with shorter PFS (HR=2.10, 95%CI [1.54; 2.85], I2 = 2% after omitting study Derosa et al, 2021 detected by leave-one-out approach), shorter OS (HR=1.69, 95%CI [1.34; 2.12], I2 = 25%) and worse ORR (OR=0.58, 95%CI [0.41; 0.84]), but no difference was observed in risk of PD (OR=1.18, 95%CI [0.97; 1.44]). No significant differences existed among the subgroups for determining the determinants of ATB inhibition.ConclusionsConcomitant ATB with immunotherapy was associated with worse PFS, OS and ORR in RCC. No publication bias was observed in this study.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=349577, identifier CRD42022349577.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1065004/fullcarcinomarenal cellantibioticsimmunotherapyimmune checkpoint inhibitorsmeta-analysis |
| spellingShingle | Zhiqiang Luo Siyuan Hao Yuxuan Li Lei Cheng Lei Cheng Xuedong Zhou Xuedong Zhou Emine Gulsen Gunes Shiyu Liu Jing Chen Jing Chen The negative effect of antibiotics on RCC patients with immunotherapy: A systematic review and meta-analysis Frontiers in Immunology carcinoma renal cell antibiotics immunotherapy immune checkpoint inhibitors meta-analysis |
| title | The negative effect of antibiotics on RCC patients with immunotherapy: A systematic review and meta-analysis |
| title_full | The negative effect of antibiotics on RCC patients with immunotherapy: A systematic review and meta-analysis |
| title_fullStr | The negative effect of antibiotics on RCC patients with immunotherapy: A systematic review and meta-analysis |
| title_full_unstemmed | The negative effect of antibiotics on RCC patients with immunotherapy: A systematic review and meta-analysis |
| title_short | The negative effect of antibiotics on RCC patients with immunotherapy: A systematic review and meta-analysis |
| title_sort | negative effect of antibiotics on rcc patients with immunotherapy a systematic review and meta analysis |
| topic | carcinoma renal cell antibiotics immunotherapy immune checkpoint inhibitors meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1065004/full |
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