DNA methylation differences in monozygotic twins with Van der Woude syndrome

DNA methylation differences in monozygotic twins with Van der Woude syndrome

IntroductionVan der Woude syndrome (VWS) is an autosomal dominant disorder responsible for 2% of all syndromic orofacial clefts (OFCs), with IRF6 being the primary causal gene (70%). Cases may present with lip pits and either cleft lip, cleft lip with cleft palate, or cleft palate, with marked pheno...

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Bibliographic Details
Main Authors: A. L. Petrin, E. Zeng, M. A. Thomas, D. Moretti-Ferreira, M. L. Marazita, X. J. Xie, J. C. Murray, L. M. Moreno-Uribe
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Dental Medicine
Subjects:
Van der Woude syndrome
DNA methylation
monozygotic twins
phenotypic discordance
cleft lip
lip pits
Online Access:https://www.frontiersin.org/articles/10.3389/fdmed.2023.1120948/full

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