Synergy between CD40 and MyD88 does not influence host survival to Salmonella infection

Synergy between CD40 and MyD88 does not influence host survival to Salmonella infection

Previous studies using purified TLR ligands plus agonistic anti-CD40 antibodies showed that TLRs and CD40 can act synergistically on dendritic cells (DCs) to optimize T cell activation and Th1 differentiation. However, a synergistic effect of TLRs and CD40 during bacterial infection is not known. He...

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Bibliographic Details
Main Authors: Ulf Alexander Wenzel, Maria eFernandez-Santoscoy, Miguel A. Tam, Pia eTegtmeyer, Mary Jo eWick
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Immunology
Subjects:
Salmonella
dendritic cell
MyD88
CD40
NFκB
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00460/full

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