Patient–Prosthesis Mismatch in Contemporary Small-Size Mechanical Prostheses Does Not Impact Survival at 10 Years
Background: The effect of PPM in mechanical prostheses on long-term survival is not well-established. Methods: Patients who received a 21 mm or smaller aortic valve between 2000 and 2011 were retrospectively analyzed (<i>n</i> = 416). Propensity matching was used in order to account for...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/9/2/48 |
| _version_ | 1797479183210774528 |
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| author | Horea Feier Mihaela Mocan Andrei Grigorescu Lucian Falnita Marian Gaspar Constantin-Tudor Luca |
| author_facet | Horea Feier Mihaela Mocan Andrei Grigorescu Lucian Falnita Marian Gaspar Constantin-Tudor Luca |
| author_sort | Horea Feier |
| collection | DOAJ |
| description | Background: The effect of PPM in mechanical prostheses on long-term survival is not well-established. Methods: Patients who received a 21 mm or smaller aortic valve between 2000 and 2011 were retrospectively analyzed (<i>n</i> = 416). Propensity matching was used in order to account for baseline differences in patient subgroups (PPM vs. no PPM; severe PPM vs. no severe PPM). Results: Five- and ten-year survival was 78 ± 3.52% and 64.51 ± 4.51% in patients with PPM, versus 83.3 ± 3.12% and 69.37 ± 4.36% in patients without (<i>p</i> = 0.28) when analyzed at 10.39 ± 5.25 years after the primary procedure. Independent risk factors for impaired survival, after matching, were age, serum creatinine, and severe pulmonary hypertension. Five- and ten-year survival in patients with severe PPM was 73.34 ± 6.01% and 61.76 ± 8.17%, respectively, versus 74.72 ± 5.68% and 67.50 ± 7.09% in those without (<i>p</i> = 0.49), at 8.82 ± 5.17 years after SAVR. Age was the only independent variable that influenced long-term survival when severe PPM was added to the model. Conclusions: PPM or severe PPM does not impact long-term survival up to 10 years in mechanical valve recipients when matching for preoperative variables. |
| first_indexed | 2024-03-09T21:41:54Z |
| format | Article |
| id | doaj.art-2716f3142e884891b0fab5ca6c0b8732 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-09T21:41:54Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-2716f3142e884891b0fab5ca6c0b87322023-11-23T20:28:21ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252022-01-01924810.3390/jcdd9020048Patient–Prosthesis Mismatch in Contemporary Small-Size Mechanical Prostheses Does Not Impact Survival at 10 YearsHorea Feier0Mihaela Mocan1Andrei Grigorescu2Lucian Falnita3Marian Gaspar4Constantin-Tudor Luca5Department of Cardiology, University of Medicine and Pharmacy “Victor Babes” Timisoara, 300041 Timisoara, RomaniaDepartment of Cardiology, University of Medicine and Pharmacy Iuliu Hatieganu Cluj-Napoca, 400012 Cluj-Napoca, RomaniaDepartment of Cardiology, University of Medicine and Pharmacy “Victor Babes” Timisoara, 300041 Timisoara, RomaniaResearch Center of the Institute for Cardiovascular Diseases, 300310 Timisoara, RomaniaDepartment of Cardiology, University of Medicine and Pharmacy “Victor Babes” Timisoara, 300041 Timisoara, RomaniaDepartment of Cardiology, University of Medicine and Pharmacy “Victor Babes” Timisoara, 300041 Timisoara, RomaniaBackground: The effect of PPM in mechanical prostheses on long-term survival is not well-established. Methods: Patients who received a 21 mm or smaller aortic valve between 2000 and 2011 were retrospectively analyzed (<i>n</i> = 416). Propensity matching was used in order to account for baseline differences in patient subgroups (PPM vs. no PPM; severe PPM vs. no severe PPM). Results: Five- and ten-year survival was 78 ± 3.52% and 64.51 ± 4.51% in patients with PPM, versus 83.3 ± 3.12% and 69.37 ± 4.36% in patients without (<i>p</i> = 0.28) when analyzed at 10.39 ± 5.25 years after the primary procedure. Independent risk factors for impaired survival, after matching, were age, serum creatinine, and severe pulmonary hypertension. Five- and ten-year survival in patients with severe PPM was 73.34 ± 6.01% and 61.76 ± 8.17%, respectively, versus 74.72 ± 5.68% and 67.50 ± 7.09% in those without (<i>p</i> = 0.49), at 8.82 ± 5.17 years after SAVR. Age was the only independent variable that influenced long-term survival when severe PPM was added to the model. Conclusions: PPM or severe PPM does not impact long-term survival up to 10 years in mechanical valve recipients when matching for preoperative variables.https://www.mdpi.com/2308-3425/9/2/48aortic valvemechanical valvepatient–prosthesis mismatchpropensity matching |
| spellingShingle | Horea Feier Mihaela Mocan Andrei Grigorescu Lucian Falnita Marian Gaspar Constantin-Tudor Luca Patient–Prosthesis Mismatch in Contemporary Small-Size Mechanical Prostheses Does Not Impact Survival at 10 Years Journal of Cardiovascular Development and Disease aortic valve mechanical valve patient–prosthesis mismatch propensity matching |
| title | Patient–Prosthesis Mismatch in Contemporary Small-Size Mechanical Prostheses Does Not Impact Survival at 10 Years |
| title_full | Patient–Prosthesis Mismatch in Contemporary Small-Size Mechanical Prostheses Does Not Impact Survival at 10 Years |
| title_fullStr | Patient–Prosthesis Mismatch in Contemporary Small-Size Mechanical Prostheses Does Not Impact Survival at 10 Years |
| title_full_unstemmed | Patient–Prosthesis Mismatch in Contemporary Small-Size Mechanical Prostheses Does Not Impact Survival at 10 Years |
| title_short | Patient–Prosthesis Mismatch in Contemporary Small-Size Mechanical Prostheses Does Not Impact Survival at 10 Years |
| title_sort | patient prosthesis mismatch in contemporary small size mechanical prostheses does not impact survival at 10 years |
| topic | aortic valve mechanical valve patient–prosthesis mismatch propensity matching |
| url | https://www.mdpi.com/2308-3425/9/2/48 |
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