Antinociceptive effect of extracts of Marrubium astracanicum Jacq. aerial parts
Objective: The genus Marrubium is used for treatment of joint pain, gout, stomach-ache and colic in Iranian Traditional Medicine. Marrubium astracanicum Jacq. (M. astracanicum) is a native species in the flora of Iran. The aim of this study was to evaluate the antinociceptive properties of various e...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2017-01-01
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| Series: | Avicenna Journal of Phytomedicine |
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| Online Access: | http://ajp.mums.ac.ir/article_7073_99ed75e0ba13f29aed48fadd9603f491.pdf |
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| author | Niloofar Kahkeshani Milad Gharedaghi Abbas Hadjiakhoondi Mohammad Sharifzadeh Mahnaz Khanavi |
| author_facet | Niloofar Kahkeshani Milad Gharedaghi Abbas Hadjiakhoondi Mohammad Sharifzadeh Mahnaz Khanavi |
| author_sort | Niloofar Kahkeshani |
| collection | DOAJ |
| description | Objective: The genus Marrubium is used for treatment of joint pain, gout, stomach-ache and colic in Iranian Traditional Medicine. Marrubium astracanicum Jacq. (M. astracanicum) is a native species in the flora of Iran. The aim of this study was to evaluate the antinociceptive properties of various extracts of aerial parts of M. astracanicum.Materials and Methods: Antinociceptive activities of total hydroalcoholic extract (THE) and its n-hexane (non-polar) and residual partition (polar) fractions were analyzed using formalin test in mice. Morphine (5 mg/kg) and normal saline were used as positive and negative controls, respectively.Results: Intraperitoneal administration of THE (50, 100 and 200 mg/kg), non-polar fraction (200 mg/kg) and polar fraction (100 and 200 mg/kg), 30 min before formalin injection, caused significant analgesic activity in acute phase (0-5 min after formalin injection) of formalin test (p0.05 in comparison with morphine). In chronic phase (15–60 min after formalin injection), non-polar and polar fractions (50, 100 and 200 mg/kg) showed significant analgesic activity (p0.05 in comparison with morphine).Conclusion: Different extracts of M. astracanicum demonstrated antinociceptive activity that support the traditional usage of Marrubium genus for the treatment of arthritis, gout and other inflammatory diseases. |
| first_indexed | 2024-04-13T20:38:40Z |
| format | Article |
| id | doaj.art-2719e9970e584f11b0b7a3f91c60c6ae |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-04-13T20:38:40Z |
| publishDate | 2017-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-2719e9970e584f11b0b7a3f91c60c6ae2022-12-22T02:30:56ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492017-01-0171737910.22038/ajp.2016.70737073Antinociceptive effect of extracts of Marrubium astracanicum Jacq. aerial partsNiloofar Kahkeshani0Milad Gharedaghi1Abbas Hadjiakhoondi2Mohammad Sharifzadeh3Mahnaz Khanavi4Department of Pharmacognosy, Faculty of Pharmacy and Persian Medicine and Pharmacy Research center, Tehran University of Medical Sciences, Tehran, IranDepartment of Pharmacognosy, Faculty of Pharmacy and Persian Medicine and Pharmacy Research center, Tehran University of Medical Sciences, Tehran, IranDepartments of Pharmacognosy and Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranDepartments of Pharmacology and Toxicology and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranFaculty of Land and Food Systems, University of British Columbia, B.C., CanadaObjective: The genus Marrubium is used for treatment of joint pain, gout, stomach-ache and colic in Iranian Traditional Medicine. Marrubium astracanicum Jacq. (M. astracanicum) is a native species in the flora of Iran. The aim of this study was to evaluate the antinociceptive properties of various extracts of aerial parts of M. astracanicum.Materials and Methods: Antinociceptive activities of total hydroalcoholic extract (THE) and its n-hexane (non-polar) and residual partition (polar) fractions were analyzed using formalin test in mice. Morphine (5 mg/kg) and normal saline were used as positive and negative controls, respectively.Results: Intraperitoneal administration of THE (50, 100 and 200 mg/kg), non-polar fraction (200 mg/kg) and polar fraction (100 and 200 mg/kg), 30 min before formalin injection, caused significant analgesic activity in acute phase (0-5 min after formalin injection) of formalin test (p0.05 in comparison with morphine). In chronic phase (15–60 min after formalin injection), non-polar and polar fractions (50, 100 and 200 mg/kg) showed significant analgesic activity (p0.05 in comparison with morphine).Conclusion: Different extracts of M. astracanicum demonstrated antinociceptive activity that support the traditional usage of Marrubium genus for the treatment of arthritis, gout and other inflammatory diseases.http://ajp.mums.ac.ir/article_7073_99ed75e0ba13f29aed48fadd9603f491.pdfMarrubium astracanicumPain measurmentAnalgesic |
| spellingShingle | Niloofar Kahkeshani Milad Gharedaghi Abbas Hadjiakhoondi Mohammad Sharifzadeh Mahnaz Khanavi Antinociceptive effect of extracts of Marrubium astracanicum Jacq. aerial parts Avicenna Journal of Phytomedicine Marrubium astracanicum Pain measurment Analgesic |
| title | Antinociceptive effect of extracts of Marrubium astracanicum Jacq. aerial parts |
| title_full | Antinociceptive effect of extracts of Marrubium astracanicum Jacq. aerial parts |
| title_fullStr | Antinociceptive effect of extracts of Marrubium astracanicum Jacq. aerial parts |
| title_full_unstemmed | Antinociceptive effect of extracts of Marrubium astracanicum Jacq. aerial parts |
| title_short | Antinociceptive effect of extracts of Marrubium astracanicum Jacq. aerial parts |
| title_sort | antinociceptive effect of extracts of marrubium astracanicum jacq aerial parts |
| topic | Marrubium astracanicum Pain measurment Analgesic |
| url | http://ajp.mums.ac.ir/article_7073_99ed75e0ba13f29aed48fadd9603f491.pdf |
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