Imbalances in faecal and duodenal <it>Bifidobacterium </it>species composition in active and non-active coeliac disease
<p>Abstract</p> <p>Background</p> <p>Gut bifidobacteria are believed to influence immune-related diseases. The objective of this study was to assess the possible relationships between the gut bifidobacteria composition and coeliac disease (CD) in children.</p> <...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2008-12-01
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| Series: | BMC Microbiology |
| Online Access: | http://www.biomedcentral.com/1471-2180/8/232 |
| _version_ | 1828487582690836480 |
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| author | Sanz Yolanda Calabuig Miguel Donat Ester Ribes-Koninckx Carmen Collado Maria |
| author_facet | Sanz Yolanda Calabuig Miguel Donat Ester Ribes-Koninckx Carmen Collado Maria |
| author_sort | Sanz Yolanda |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Gut bifidobacteria are believed to influence immune-related diseases. The objective of this study was to assess the possible relationships between the gut bifidobacteria composition and coeliac disease (CD) in children.</p> <p>A total of 48 faecal samples (30 and 18 samples from active and no active CD patients, respectively) and 33 duodenal biopsy specimens of CD patients (25 and 8 samples from active and non-active CD patients, respectively) were analysed. Samples (30 faecal samples and 8 biopsies) from a control age-matched group of children were also included for comparative purposes. Gut <it>Bifidobacterium </it>genus and species were analyzed by real-time PCR.</p> <p>Results</p> <p>Active and non-active CD patients showed lower numbers of total <it>Bifidobacterium </it>and <it>B. longum </it>species in faeces and duodenal biopsies than controls, and these differences were particularly remarkable between active CD patients and controls. <it>B. catenulatum </it>prevalence was higher in biopsies of controls than in those of active and non-active CD patients, whereas <it>B. dentium </it>prevalence was higher in faeces of non-active CD patients than in controls. Correlations between levels of <it>Bifidobacterium </it>and <it>B. longum </it>species in faecal and biopsy samples were detected in both CD patients and controls.</p> <p>Conclusion</p> <p>Reductions in total <it>Bifidobacterium </it>and <it>B. longum </it>populations were associated with both active and non-active CD when compared to controls. These bacterial groups could constitute novel targets for adjuvant dietary therapies although the confirmation of this hypothesis would require further investigations.</p> |
| first_indexed | 2024-12-11T09:53:20Z |
| format | Article |
| id | doaj.art-271a396fce5745988ddd0495d4a1002c |
| institution | Directory Open Access Journal |
| issn | 1471-2180 |
| language | English |
| last_indexed | 2024-12-11T09:53:20Z |
| publishDate | 2008-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Microbiology |
| spelling | doaj.art-271a396fce5745988ddd0495d4a1002c2022-12-22T01:12:19ZengBMCBMC Microbiology1471-21802008-12-018123210.1186/1471-2180-8-232Imbalances in faecal and duodenal <it>Bifidobacterium </it>species composition in active and non-active coeliac diseaseSanz YolandaCalabuig MiguelDonat EsterRibes-Koninckx CarmenCollado Maria<p>Abstract</p> <p>Background</p> <p>Gut bifidobacteria are believed to influence immune-related diseases. The objective of this study was to assess the possible relationships between the gut bifidobacteria composition and coeliac disease (CD) in children.</p> <p>A total of 48 faecal samples (30 and 18 samples from active and no active CD patients, respectively) and 33 duodenal biopsy specimens of CD patients (25 and 8 samples from active and non-active CD patients, respectively) were analysed. Samples (30 faecal samples and 8 biopsies) from a control age-matched group of children were also included for comparative purposes. Gut <it>Bifidobacterium </it>genus and species were analyzed by real-time PCR.</p> <p>Results</p> <p>Active and non-active CD patients showed lower numbers of total <it>Bifidobacterium </it>and <it>B. longum </it>species in faeces and duodenal biopsies than controls, and these differences were particularly remarkable between active CD patients and controls. <it>B. catenulatum </it>prevalence was higher in biopsies of controls than in those of active and non-active CD patients, whereas <it>B. dentium </it>prevalence was higher in faeces of non-active CD patients than in controls. Correlations between levels of <it>Bifidobacterium </it>and <it>B. longum </it>species in faecal and biopsy samples were detected in both CD patients and controls.</p> <p>Conclusion</p> <p>Reductions in total <it>Bifidobacterium </it>and <it>B. longum </it>populations were associated with both active and non-active CD when compared to controls. These bacterial groups could constitute novel targets for adjuvant dietary therapies although the confirmation of this hypothesis would require further investigations.</p>http://www.biomedcentral.com/1471-2180/8/232 |
| spellingShingle | Sanz Yolanda Calabuig Miguel Donat Ester Ribes-Koninckx Carmen Collado Maria Imbalances in faecal and duodenal <it>Bifidobacterium </it>species composition in active and non-active coeliac disease BMC Microbiology |
| title | Imbalances in faecal and duodenal <it>Bifidobacterium </it>species composition in active and non-active coeliac disease |
| title_full | Imbalances in faecal and duodenal <it>Bifidobacterium </it>species composition in active and non-active coeliac disease |
| title_fullStr | Imbalances in faecal and duodenal <it>Bifidobacterium </it>species composition in active and non-active coeliac disease |
| title_full_unstemmed | Imbalances in faecal and duodenal <it>Bifidobacterium </it>species composition in active and non-active coeliac disease |
| title_short | Imbalances in faecal and duodenal <it>Bifidobacterium </it>species composition in active and non-active coeliac disease |
| title_sort | imbalances in faecal and duodenal it bifidobacterium it species composition in active and non active coeliac disease |
| url | http://www.biomedcentral.com/1471-2180/8/232 |
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