Enhanced Loading Efficiency and Mucoadhesion Properties of Gellan Gum Thin Films by Complexation with Hydroxypropyl-β-Cyclodextrin

Enhanced Loading Efficiency and Mucoadhesion Properties of Gellan Gum Thin Films by Complexation with Hydroxypropyl-β-Cyclodextrin

Polymeric oral thin films (OTFs) were prepared by the casting method, combining gellan gum (GG), a water-soluble polysaccharide, and glycerol (Gly) as a plasticizing agent. GG-Gly films were investigated as potential systems for buccal drug delivery using fluconazole (Class I of the Biopharmaceutica...

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Bibliographic Details
Main Authors: Alessandra Adrover, Laura di Muzio, Jordan Trilli, Chiara Brandelli, Patrizia Paolicelli, Stefania Petralito, Maria Antonietta Casadei
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Pharmaceutics
Subjects:
thin films
drug delivery
gellan gum
cyclodextrins
USP II
millifluidic flow-through device
Online Access:https://www.mdpi.com/1999-4923/12/9/819

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