Non-invasive electroencephalographical (EEG) recording system in awake monkeys
Background: Human clinical studies reported that several electroencephalographical (EEG) parameters can be used as biomarkers of psychiatric disorders. EEGs recorded from non-human primates (monkeys) is useful for understanding of human pathologies of psychiatric disorders and development of new the...
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| Format: | Article |
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Elsevier
2020-05-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844020308872 |
| _version_ | 1828812266986799104 |
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| author | Tomoya Nakamura Trong Ha Dinh Makoto Asai Hiroshi Nishimaru Jumpei Matsumoto Yusaku Takamura Etsuro Hori Sokichi Honda Hiroshi Yamada Takuma Mihara Mitsuyuki Matsumoto Hisao Nishijo |
| author_facet | Tomoya Nakamura Trong Ha Dinh Makoto Asai Hiroshi Nishimaru Jumpei Matsumoto Yusaku Takamura Etsuro Hori Sokichi Honda Hiroshi Yamada Takuma Mihara Mitsuyuki Matsumoto Hisao Nishijo |
| author_sort | Tomoya Nakamura |
| collection | DOAJ |
| description | Background: Human clinical studies reported that several electroencephalographical (EEG) parameters can be used as biomarkers of psychiatric disorders. EEGs recorded from non-human primates (monkeys) is useful for understanding of human pathologies of psychiatric disorders and development of new therapeutic agents. New methods: In this study, we expand a previous non-invasive head holding system with face masks for awake monkeys to be applied to scalp EEG recording. The new design of a head holding system allows to attach scalp EEG electrodes on the positions comparable to human electrode placement and to present auditory stimuli. Results: With this system, we could record auditory evoked potentials (AEPs) in auditory sensory gating and oddball paradigms, which are often used as biomarkers of psychiatric disorders in animal models and human patients. The recorded AEPs were comparable to previous human clinical data. Comparison with existing methods: Compared with previous non-invasive head holding systems, top, side (cheek and ears), and rear of the head can be open for attachment of EEG electrodes and auditory stimulation in the present system. Conclusions: The results suggest that the present system is useful in EEG recording from awake monkeys. Furthermore, this system can be applied to eye-tracking and chronic intra-cerebral recording experiments. |
| first_indexed | 2024-12-12T09:41:14Z |
| format | Article |
| id | doaj.art-271d8537598f45b28adadc584b885d37 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-12T09:41:14Z |
| publishDate | 2020-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-271d8537598f45b28adadc584b885d372022-12-22T00:28:33ZengElsevierHeliyon2405-84402020-05-0165e04043Non-invasive electroencephalographical (EEG) recording system in awake monkeysTomoya Nakamura0Trong Ha Dinh1Makoto Asai2Hiroshi Nishimaru3Jumpei Matsumoto4Yusaku Takamura5Etsuro Hori6Sokichi Honda7Hiroshi Yamada8Takuma Mihara9Mitsuyuki Matsumoto10Hisao Nishijo11System Emotional Science, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan; Department of Anatomy, Faculty of Medicine, University of Toyama, Toyama 930-0194, JapanSystem Emotional Science, Faculty of Medicine, University of Toyama, Toyama 930-0194, JapanCandidate Discovery Science Labs, Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki 305-8585, JapanSystem Emotional Science, Faculty of Medicine, University of Toyama, Toyama 930-0194, JapanSystem Emotional Science, Faculty of Medicine, University of Toyama, Toyama 930-0194, JapanSystem Emotional Science, Faculty of Medicine, University of Toyama, Toyama 930-0194, JapanSystem Emotional Science, Faculty of Medicine, University of Toyama, Toyama 930-0194, JapanCandidate Discovery Science Labs, Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki 305-8585, JapanCandidate Discovery Science Labs, Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki 305-8585, JapanCandidate Discovery Science Labs, Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki 305-8585, JapanCandidate Discovery Science Labs, Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki 305-8585, JapanSystem Emotional Science, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan; Corresponding author.Background: Human clinical studies reported that several electroencephalographical (EEG) parameters can be used as biomarkers of psychiatric disorders. EEGs recorded from non-human primates (monkeys) is useful for understanding of human pathologies of psychiatric disorders and development of new therapeutic agents. New methods: In this study, we expand a previous non-invasive head holding system with face masks for awake monkeys to be applied to scalp EEG recording. The new design of a head holding system allows to attach scalp EEG electrodes on the positions comparable to human electrode placement and to present auditory stimuli. Results: With this system, we could record auditory evoked potentials (AEPs) in auditory sensory gating and oddball paradigms, which are often used as biomarkers of psychiatric disorders in animal models and human patients. The recorded AEPs were comparable to previous human clinical data. Comparison with existing methods: Compared with previous non-invasive head holding systems, top, side (cheek and ears), and rear of the head can be open for attachment of EEG electrodes and auditory stimulation in the present system. Conclusions: The results suggest that the present system is useful in EEG recording from awake monkeys. Furthermore, this system can be applied to eye-tracking and chronic intra-cerebral recording experiments.http://www.sciencedirect.com/science/article/pii/S2405844020308872NeuroscienceNeurologyPhysiologyBehavioral testCognitionConsciousness |
| spellingShingle | Tomoya Nakamura Trong Ha Dinh Makoto Asai Hiroshi Nishimaru Jumpei Matsumoto Yusaku Takamura Etsuro Hori Sokichi Honda Hiroshi Yamada Takuma Mihara Mitsuyuki Matsumoto Hisao Nishijo Non-invasive electroencephalographical (EEG) recording system in awake monkeys Heliyon Neuroscience Neurology Physiology Behavioral test Cognition Consciousness |
| title | Non-invasive electroencephalographical (EEG) recording system in awake monkeys |
| title_full | Non-invasive electroencephalographical (EEG) recording system in awake monkeys |
| title_fullStr | Non-invasive electroencephalographical (EEG) recording system in awake monkeys |
| title_full_unstemmed | Non-invasive electroencephalographical (EEG) recording system in awake monkeys |
| title_short | Non-invasive electroencephalographical (EEG) recording system in awake monkeys |
| title_sort | non invasive electroencephalographical eeg recording system in awake monkeys |
| topic | Neuroscience Neurology Physiology Behavioral test Cognition Consciousness |
| url | http://www.sciencedirect.com/science/article/pii/S2405844020308872 |
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