ZPD-2, a Small Compound That Inhibits α-Synuclein Amyloid Aggregation and Its Seeded Polymerization

ZPD-2, a Small Compound That Inhibits α-Synuclein Amyloid Aggregation and Its Seeded Polymerization

α-Synuclein (α-Syn) forms toxic intracellular protein inclusions and transmissible amyloid structures in Parkinson’s disease (PD). Preventing α-Syn self-assembly has become one of the most promising approaches in the search for disease-modifying treatments for this neurodegenerative disorder. Here,...

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Bibliographic Details
Main Authors: Samuel Peña-Díaz, Jordi Pujols, María Conde-Giménez, Anita Čarija, Esther Dalfo, Jesús García, Susanna Navarro, Francisca Pinheiro, Jaime Santos, Xavier Salvatella, Javier Sancho, Salvador Ventura
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Parkinson’s disease
α-synuclein
amyloid
protein aggregation
aggregation inhibitor
Caenorhabditis elegans
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00306/full

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