Peroxisomal Proliferator-Activated Receptor β/δ Deficiency Induces Cognitive Alterations

Peroxisomal Proliferator-Activated Receptor β/δ Deficiency Induces Cognitive Alterations

Peroxisome proliferator-activated receptor β/δ (PPARβ/δ), the most PPAR abundant isotype in the central nervous system, is involved in microglial homeostasis and metabolism, whose disturbances have been demonstrated to play a key role in memory impairment. Although PPARβ/δ function is well-establish...

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Bibliographic Details
Main Authors: Triana Espinosa-Jiménez, Oriol Busquets, Amanda Cano, Elena Sánchez-López, Ester Verdaguer, Antoni Parcerisas, Jordi Olloquequi, Carme Auladell, Jaume Folch, Walter Wahli, Manuel Vázquez-Carrera, Antoni Camins, Miren Ettcheto
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Pharmacology
Subjects:
PPARβ/δ
memory impairment
high-fat diet
neuroinflammation
dendritic spines
synapsis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.902047/full

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