Telomere length across different UIP fibrotic-Interstitial Lung Diseases: a prospective Greek case-control study
Introduction: Short telomeres are recognized as risk factor for idiopathic pulmonary fibrosis (IPF). We aimed to assess the role of telomere length (TL) in fibrotic-Interstitial Lung Diseases (f-ILDs) associated with a usual interstitial pneumonia (UIP) pattern as well as in IPF acute exacerbation (...
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| Format: | Article |
| Language: | English |
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Elsevier España
2022-07-01
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| Series: | Pulmonology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531043720302488 |
| _version_ | 1811231384851709952 |
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| author | I. Tomos A. Karakatsani E.D. Manali C. Kottaridi A. Spathis S. Argentos S.A. Papiris |
| author_facet | I. Tomos A. Karakatsani E.D. Manali C. Kottaridi A. Spathis S. Argentos S.A. Papiris |
| author_sort | I. Tomos |
| collection | DOAJ |
| description | Introduction: Short telomeres are recognized as risk factor for idiopathic pulmonary fibrosis (IPF). We aimed to assess the role of telomere length (TL) in fibrotic-Interstitial Lung Diseases (f-ILDs) associated with a usual interstitial pneumonia (UIP) pattern as well as in IPF acute exacerbation (IPF-AE). Aim and methods: TL was measured from peripheral white blood cells using a multiplex quantitative polymerase chain reaction in consecutive patients with f-ILDs, all presenting UIP pattern in the high-resolution chest-computed-tomography and compared to age-matched healthy controls. Results: Seventy-nine individuals were included (mean age 69.77 ± 0.72 years); 24 stable IPF, 18 IPF-AE, 10 combined pulmonary fibrosis and emphysema, 7 Rheumatoid arthritis-UIP-ILDs and 20 controls. TL in all patients was significantly shorter compared to controls [mean T/S ratio (SE) 0.77 (±0.05) vs 2.26 (±0.36), p < 0.001] as well as separately in each one of f-ILD subgroups. IPF-AE patients presented significantly shorter TL compared to stable IPF (p = 0.029). Patients with IPF and shorter than the median TL (0−0.72) showed reduced overall survival (p = 0.004). T/S < 0.72 was associated with increased risk for IPF-AE (OR = 30.787, 95% CI: 2.153, 440.183, p = 0.012) independent of age, gender, smoking and lung function impairment. A protective effect of TL was observed, as it was inversely associated with risk of death both in UIP-f-ILDs (HR = 0.174, 95%CI: 0.036, 0.846, p = 0.030) and IPF patients (HR = 0.096, 95%CI: 0.011, 0.849, p = 0.035). Conclusions: Shorter TL characterizes different UIP f-ILDs. Although no difference was observed in TL among diverse UIP subgroups, IPF-AE presented shorter TL compared to stable IPF. Reduced overall survival and higher hazard ratio of death are associated with shorter TL in IPF. |
| first_indexed | 2024-04-12T10:44:24Z |
| format | Article |
| id | doaj.art-27234fa7b60846f8a7e29561cae95b18 |
| institution | Directory Open Access Journal |
| issn | 2531-0437 |
| language | English |
| last_indexed | 2024-04-12T10:44:24Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Pulmonology |
| spelling | doaj.art-27234fa7b60846f8a7e29561cae95b182022-12-22T03:36:29ZengElsevier EspañaPulmonology2531-04372022-07-01284254261Telomere length across different UIP fibrotic-Interstitial Lung Diseases: a prospective Greek case-control studyI. Tomos0A. Karakatsani1E.D. Manali2C. Kottaridi3A. Spathis4S. Argentos5S.A. Papiris62nd Pulmonary Medicine Department, “ATTIKON” University Hospital, National and Kapodistrian University of Athens, Greece2nd Pulmonary Medicine Department, “ATTIKON” University Hospital, National and Kapodistrian University of Athens, Greece2nd Pulmonary Medicine Department, “ATTIKON” University Hospital, National and Kapodistrian University of Athens, Greece2nd Department of Cytopathology, “ATTIKON” University Hospital, National and Kapodistrian University of Athens, Greece2nd Department of Cytopathology, “ATTIKON” University Hospital, National and Kapodistrian University of Athens, Greece2nd Department of Radiology, “ATTIKON” University Hospital, National and Kapodistrian University of Athens, Greece2nd Pulmonary Medicine Department, “ATTIKON” University Hospital, National and Kapodistrian University of Athens, Greece; Corresponding author at: 2nd Pulmonary Medicine Department, “ATTIKON” University Hospital, 1 Rimini Street, 12462, Haidari, Greece.Introduction: Short telomeres are recognized as risk factor for idiopathic pulmonary fibrosis (IPF). We aimed to assess the role of telomere length (TL) in fibrotic-Interstitial Lung Diseases (f-ILDs) associated with a usual interstitial pneumonia (UIP) pattern as well as in IPF acute exacerbation (IPF-AE). Aim and methods: TL was measured from peripheral white blood cells using a multiplex quantitative polymerase chain reaction in consecutive patients with f-ILDs, all presenting UIP pattern in the high-resolution chest-computed-tomography and compared to age-matched healthy controls. Results: Seventy-nine individuals were included (mean age 69.77 ± 0.72 years); 24 stable IPF, 18 IPF-AE, 10 combined pulmonary fibrosis and emphysema, 7 Rheumatoid arthritis-UIP-ILDs and 20 controls. TL in all patients was significantly shorter compared to controls [mean T/S ratio (SE) 0.77 (±0.05) vs 2.26 (±0.36), p < 0.001] as well as separately in each one of f-ILD subgroups. IPF-AE patients presented significantly shorter TL compared to stable IPF (p = 0.029). Patients with IPF and shorter than the median TL (0−0.72) showed reduced overall survival (p = 0.004). T/S < 0.72 was associated with increased risk for IPF-AE (OR = 30.787, 95% CI: 2.153, 440.183, p = 0.012) independent of age, gender, smoking and lung function impairment. A protective effect of TL was observed, as it was inversely associated with risk of death both in UIP-f-ILDs (HR = 0.174, 95%CI: 0.036, 0.846, p = 0.030) and IPF patients (HR = 0.096, 95%CI: 0.011, 0.849, p = 0.035). Conclusions: Shorter TL characterizes different UIP f-ILDs. Although no difference was observed in TL among diverse UIP subgroups, IPF-AE presented shorter TL compared to stable IPF. Reduced overall survival and higher hazard ratio of death are associated with shorter TL in IPF.http://www.sciencedirect.com/science/article/pii/S2531043720302488Telomere lengthUsual interstitial pneumoniaFibrotic-interstitial lung diseasesIdiopathic pulmonary fibrosisAcute exacerbation of idiopathic pulmonary fibrosis |
| spellingShingle | I. Tomos A. Karakatsani E.D. Manali C. Kottaridi A. Spathis S. Argentos S.A. Papiris Telomere length across different UIP fibrotic-Interstitial Lung Diseases: a prospective Greek case-control study Pulmonology Telomere length Usual interstitial pneumonia Fibrotic-interstitial lung diseases Idiopathic pulmonary fibrosis Acute exacerbation of idiopathic pulmonary fibrosis |
| title | Telomere length across different UIP fibrotic-Interstitial Lung Diseases: a prospective Greek case-control study |
| title_full | Telomere length across different UIP fibrotic-Interstitial Lung Diseases: a prospective Greek case-control study |
| title_fullStr | Telomere length across different UIP fibrotic-Interstitial Lung Diseases: a prospective Greek case-control study |
| title_full_unstemmed | Telomere length across different UIP fibrotic-Interstitial Lung Diseases: a prospective Greek case-control study |
| title_short | Telomere length across different UIP fibrotic-Interstitial Lung Diseases: a prospective Greek case-control study |
| title_sort | telomere length across different uip fibrotic interstitial lung diseases a prospective greek case control study |
| topic | Telomere length Usual interstitial pneumonia Fibrotic-interstitial lung diseases Idiopathic pulmonary fibrosis Acute exacerbation of idiopathic pulmonary fibrosis |
| url | http://www.sciencedirect.com/science/article/pii/S2531043720302488 |
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